A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System. / Bhumika, Stitipragyan; Nakamura, Mari; Valerio, Patricia; Solyga, Magdalena; Lindén, Henrik; Barkat, Tania R.

In: Cerebral Cortex, Vol. 30, No. 4, 2020, p. 2586-2599.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bhumika, S, Nakamura, M, Valerio, P, Solyga, M, Lindén, H & Barkat, TR 2020, 'A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System', Cerebral Cortex, vol. 30, no. 4, pp. 2586-2599. https://doi.org/10.1093/cercor/bhz262

APA

Bhumika, S., Nakamura, M., Valerio, P., Solyga, M., Lindén, H., & Barkat, T. R. (2020). A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System. Cerebral Cortex, 30(4), 2586-2599. https://doi.org/10.1093/cercor/bhz262

Vancouver

Bhumika S, Nakamura M, Valerio P, Solyga M, Lindén H, Barkat TR. A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System. Cerebral Cortex. 2020;30(4):2586-2599. https://doi.org/10.1093/cercor/bhz262

Author

Bhumika, Stitipragyan ; Nakamura, Mari ; Valerio, Patricia ; Solyga, Magdalena ; Lindén, Henrik ; Barkat, Tania R. / A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System. In: Cerebral Cortex. 2020 ; Vol. 30, No. 4. pp. 2586-2599.

Bibtex

@article{035b35b9fb9e48a382bb54b57f57e1c9,
title = "A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System",
abstract = "Neuronal circuits are shaped by experience during time windows of increased plasticity in postnatal development. In the auditory system, the critical period for the simplest sounds-pure frequency tones-is well defined. Critical periods for more complex sounds remain to be elucidated. We used in vivo electrophysiological recordings in the mouse auditory cortex to demonstrate that passive exposure to frequency modulated sweeps (FMS) from postnatal day 31 to 38 leads to long-Term changes in the temporal representation of sweep directions. Immunohistochemical analysis revealed a decreased percentage of layer 4 parvalbumin-positive (PV+) cells during this critical period, paralleled with a transient increase in responses to FMS, but not to pure tones. Preventing the PV+ cell decrease with continuous white noise exposure delayed the critical period onset, suggesting a reduction in inhibition as a mechanism for this plasticity. Our findings shed new light on the dependence of plastic windows on stimulus complexity that persistently sculpt the functional organization of the auditory cortex.",
keywords = "auditory cortex, frequency modulated sweep, juvenile development, parvalbumin positive neurons, sensory processing",
author = "Stitipragyan Bhumika and Mari Nakamura and Patricia Valerio and Magdalena Solyga and Henrik Lind{\'e}n and Barkat, {Tania R.}",
year = "2020",
doi = "10.1093/cercor/bhz262",
language = "English",
volume = "30",
pages = "2586--2599",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System

AU - Bhumika, Stitipragyan

AU - Nakamura, Mari

AU - Valerio, Patricia

AU - Solyga, Magdalena

AU - Lindén, Henrik

AU - Barkat, Tania R.

PY - 2020

Y1 - 2020

N2 - Neuronal circuits are shaped by experience during time windows of increased plasticity in postnatal development. In the auditory system, the critical period for the simplest sounds-pure frequency tones-is well defined. Critical periods for more complex sounds remain to be elucidated. We used in vivo electrophysiological recordings in the mouse auditory cortex to demonstrate that passive exposure to frequency modulated sweeps (FMS) from postnatal day 31 to 38 leads to long-Term changes in the temporal representation of sweep directions. Immunohistochemical analysis revealed a decreased percentage of layer 4 parvalbumin-positive (PV+) cells during this critical period, paralleled with a transient increase in responses to FMS, but not to pure tones. Preventing the PV+ cell decrease with continuous white noise exposure delayed the critical period onset, suggesting a reduction in inhibition as a mechanism for this plasticity. Our findings shed new light on the dependence of plastic windows on stimulus complexity that persistently sculpt the functional organization of the auditory cortex.

AB - Neuronal circuits are shaped by experience during time windows of increased plasticity in postnatal development. In the auditory system, the critical period for the simplest sounds-pure frequency tones-is well defined. Critical periods for more complex sounds remain to be elucidated. We used in vivo electrophysiological recordings in the mouse auditory cortex to demonstrate that passive exposure to frequency modulated sweeps (FMS) from postnatal day 31 to 38 leads to long-Term changes in the temporal representation of sweep directions. Immunohistochemical analysis revealed a decreased percentage of layer 4 parvalbumin-positive (PV+) cells during this critical period, paralleled with a transient increase in responses to FMS, but not to pure tones. Preventing the PV+ cell decrease with continuous white noise exposure delayed the critical period onset, suggesting a reduction in inhibition as a mechanism for this plasticity. Our findings shed new light on the dependence of plastic windows on stimulus complexity that persistently sculpt the functional organization of the auditory cortex.

KW - auditory cortex

KW - frequency modulated sweep

KW - juvenile development

KW - parvalbumin positive neurons

KW - sensory processing

U2 - 10.1093/cercor/bhz262

DO - 10.1093/cercor/bhz262

M3 - Journal article

C2 - 31800018

AN - SCOPUS:85083912773

VL - 30

SP - 2586

EP - 2599

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 4

ER -

ID: 242707570