5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current

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5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. / Perrier, Jean françois; Hounsgaard, Jorn.

In: Journal of Neurophysiology, Vol. 89, No. 2, 01.02.2003, p. 954-959.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perrier, JF & Hounsgaard, J 2003, '5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current', Journal of Neurophysiology, vol. 89, no. 2, pp. 954-959. https://doi.org/10.1152/jn.00753.2002

APA

Perrier, J. F., & Hounsgaard, J. (2003). 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. Journal of Neurophysiology, 89(2), 954-959. https://doi.org/10.1152/jn.00753.2002

Vancouver

Perrier JF, Hounsgaard J. 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. Journal of Neurophysiology. 2003 Feb 1;89(2):954-959. https://doi.org/10.1152/jn.00753.2002

Author

Perrier, Jean françois ; Hounsgaard, Jorn. / 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. In: Journal of Neurophysiology. 2003 ; Vol. 89, No. 2. pp. 954-959.

Bibtex

@article{b3d6ea8b697340079048af7f419b1b90,
title = "5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current",
abstract = "The effects of serotonin (5-HT) on intrinsic properties of spinal motoneurons were investigated with intracellular recordings in a slice preparation from adult turtles. In 55% of the cells that were recorded, addition of 5-HT to the extracellular medium promoted plateau potentials as revealed by the response to depolarizing current pulses applied through the intracellular electrode. In the remaining 45% of cells, 5-HT had an inhibitory effect. However, when tested with an applied electric field that preferentially polarizes distal dendrites, 5-HT facilitated plateau potentials in 100% of the cells. Plateau potentials were also promoted by 5-HT focally applied on a dendrite by iontophoresis. Applied near the soma, 5-HT either promoted plateau potentials or inhibited spike generation. The latter effect was accompanied by a decrease in input resistance. Voltage-clamp recordings showed that the facilitation of plateau potentials mediated by L-type Ca2+ channels was due to activation of 5-HT2 receptors. These findings show that 5-HT regulates intrinsic properties of motoneurons in opposite ways: activation of 5-HT receptors in the soma region inhibits spike generation and plateau potentials, while activation of 5-HT2 receptors in the dendrites and the soma region promotes spiking by facilitation of plateau potentials mediated by L-type Ca2+ channels.",
author = "Perrier, {Jean fran{\c c}ois} and Jorn Hounsgaard",
year = "2003",
month = feb,
day = "1",
doi = "10.1152/jn.00753.2002",
language = "English",
volume = "89",
pages = "954--959",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current

AU - Perrier, Jean françois

AU - Hounsgaard, Jorn

PY - 2003/2/1

Y1 - 2003/2/1

N2 - The effects of serotonin (5-HT) on intrinsic properties of spinal motoneurons were investigated with intracellular recordings in a slice preparation from adult turtles. In 55% of the cells that were recorded, addition of 5-HT to the extracellular medium promoted plateau potentials as revealed by the response to depolarizing current pulses applied through the intracellular electrode. In the remaining 45% of cells, 5-HT had an inhibitory effect. However, when tested with an applied electric field that preferentially polarizes distal dendrites, 5-HT facilitated plateau potentials in 100% of the cells. Plateau potentials were also promoted by 5-HT focally applied on a dendrite by iontophoresis. Applied near the soma, 5-HT either promoted plateau potentials or inhibited spike generation. The latter effect was accompanied by a decrease in input resistance. Voltage-clamp recordings showed that the facilitation of plateau potentials mediated by L-type Ca2+ channels was due to activation of 5-HT2 receptors. These findings show that 5-HT regulates intrinsic properties of motoneurons in opposite ways: activation of 5-HT receptors in the soma region inhibits spike generation and plateau potentials, while activation of 5-HT2 receptors in the dendrites and the soma region promotes spiking by facilitation of plateau potentials mediated by L-type Ca2+ channels.

AB - The effects of serotonin (5-HT) on intrinsic properties of spinal motoneurons were investigated with intracellular recordings in a slice preparation from adult turtles. In 55% of the cells that were recorded, addition of 5-HT to the extracellular medium promoted plateau potentials as revealed by the response to depolarizing current pulses applied through the intracellular electrode. In the remaining 45% of cells, 5-HT had an inhibitory effect. However, when tested with an applied electric field that preferentially polarizes distal dendrites, 5-HT facilitated plateau potentials in 100% of the cells. Plateau potentials were also promoted by 5-HT focally applied on a dendrite by iontophoresis. Applied near the soma, 5-HT either promoted plateau potentials or inhibited spike generation. The latter effect was accompanied by a decrease in input resistance. Voltage-clamp recordings showed that the facilitation of plateau potentials mediated by L-type Ca2+ channels was due to activation of 5-HT2 receptors. These findings show that 5-HT regulates intrinsic properties of motoneurons in opposite ways: activation of 5-HT receptors in the soma region inhibits spike generation and plateau potentials, while activation of 5-HT2 receptors in the dendrites and the soma region promotes spiking by facilitation of plateau potentials mediated by L-type Ca2+ channels.

UR - http://www.scopus.com/inward/record.url?scp=0037289839&partnerID=8YFLogxK

U2 - 10.1152/jn.00753.2002

DO - 10.1152/jn.00753.2002

M3 - Journal article

C2 - 12574471

AN - SCOPUS:0037289839

VL - 89

SP - 954

EP - 959

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -

ID: 237698668