5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. / Perrier, Jean François; Alaburda, Aidas; Hounsgaard, Jørn.

In: Journal of Physiology, Vol. 548, No. 2, 15.04.2003, p. 485-492.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perrier, JF, Alaburda, A & Hounsgaard, J 2003, '5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle', Journal of Physiology, vol. 548, no. 2, pp. 485-492. https://doi.org/10.1113/jphysiol.2002.037952

APA

Perrier, J. F., Alaburda, A., & Hounsgaard, J. (2003). 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. Journal of Physiology, 548(2), 485-492. https://doi.org/10.1113/jphysiol.2002.037952

Vancouver

Perrier JF, Alaburda A, Hounsgaard J. 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. Journal of Physiology. 2003 Apr 15;548(2):485-492. https://doi.org/10.1113/jphysiol.2002.037952

Author

Perrier, Jean François ; Alaburda, Aidas ; Hounsgaard, Jørn. / 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. In: Journal of Physiology. 2003 ; Vol. 548, No. 2. pp. 485-492.

Bibtex

@article{e81b59f2bdeb430fbeda3bf1879abd8c,
title = "5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle",
abstract = "The modulatory effects of serotonin mediated by 5-HT1A receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. In current-clamp mode, activation of 5-HT1A receptors by 8-OH-DPAT led to depolarization and an increase in input resistance in most motoneurons but caused hyperpolarization and a decrease in input resistance in the remaining smaller fraction of cells. When slices were preincubated in medium containing the 5-HT1A receptor antagonist WAY-100635, 8-OH-DPAT had no effect. In voltage-clamp mode, with 1 mM CsCl in the bathing medium, 8-OH-DPAT consistently inhibited a leak current that was sensitive to extracellular acidification and anandamide, a TASK-1 channel blocker. In medium with a low pH, as in the presence of anandamide, 8-OH-DPAT had no effect. Our results show that activation of 5-HT1A receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a TASK-1 potassium channel leading to depolarization and increased input resistance.",
author = "Perrier, {Jean Fran{\c c}ois} and Aidas Alaburda and J{\o}rn Hounsgaard",
year = "2003",
month = apr,
day = "15",
doi = "10.1113/jphysiol.2002.037952",
language = "English",
volume = "548",
pages = "485--492",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle

AU - Perrier, Jean François

AU - Alaburda, Aidas

AU - Hounsgaard, Jørn

PY - 2003/4/15

Y1 - 2003/4/15

N2 - The modulatory effects of serotonin mediated by 5-HT1A receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. In current-clamp mode, activation of 5-HT1A receptors by 8-OH-DPAT led to depolarization and an increase in input resistance in most motoneurons but caused hyperpolarization and a decrease in input resistance in the remaining smaller fraction of cells. When slices were preincubated in medium containing the 5-HT1A receptor antagonist WAY-100635, 8-OH-DPAT had no effect. In voltage-clamp mode, with 1 mM CsCl in the bathing medium, 8-OH-DPAT consistently inhibited a leak current that was sensitive to extracellular acidification and anandamide, a TASK-1 channel blocker. In medium with a low pH, as in the presence of anandamide, 8-OH-DPAT had no effect. Our results show that activation of 5-HT1A receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a TASK-1 potassium channel leading to depolarization and increased input resistance.

AB - The modulatory effects of serotonin mediated by 5-HT1A receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. In current-clamp mode, activation of 5-HT1A receptors by 8-OH-DPAT led to depolarization and an increase in input resistance in most motoneurons but caused hyperpolarization and a decrease in input resistance in the remaining smaller fraction of cells. When slices were preincubated in medium containing the 5-HT1A receptor antagonist WAY-100635, 8-OH-DPAT had no effect. In voltage-clamp mode, with 1 mM CsCl in the bathing medium, 8-OH-DPAT consistently inhibited a leak current that was sensitive to extracellular acidification and anandamide, a TASK-1 channel blocker. In medium with a low pH, as in the presence of anandamide, 8-OH-DPAT had no effect. Our results show that activation of 5-HT1A receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a TASK-1 potassium channel leading to depolarization and increased input resistance.

UR - http://www.scopus.com/inward/record.url?scp=85006850803&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.2002.037952

DO - 10.1113/jphysiol.2002.037952

M3 - Journal article

AN - SCOPUS:85006850803

VL - 548

SP - 485

EP - 492

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 2

ER -

ID: 237698578