Søren Gøgsig Faarup Rasmussen
Associate Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
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A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S., Gether, Ulrik, Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Gellman, S. H., 27 Jul 2012, In: Chemistry: A European Journal. 18, 31, p. 9485-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A general protocol for the generation of Nanobodies for structural biology
Pardon, E., Laeremans, T., Triest, S., Rasmussen, Søren Gøgsig Faarup, Wohlkönig, A., Ruf, A., Muyldermans, S., Hol, W. G. J., Kobilka, B. K. & Steyaert, J., Mar 2014, In: Nature Protocols (Print). 9, 3, p. 674-93 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A monoclonal antibody for G protein-coupled receptor crystallography
Day, P. W., Rasmussen, Søren Gøgsig Faarup, Parnot, C., Fung, J. J., Masood, A., Kobilka, T. S., Yao, X., Choi, H., Weis, W. I., Rohrer, D. K. & Kobilka, B. K., Nov 2007, In: Nature Methods. 4, 11, p. 927-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
Whorton, M. R., Bokoch, M. P., Rasmussen, Søren Gøgsig Faarup, Huang, B., Zare, R. N., Kobilka, B. & Sunahara, R. K., 1 May 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7682-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
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Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
DeVree, B. T., Mahoney, J. P., Vélez-Ruiz, G. A., Rasmussen, Søren Gøgsig Faarup, Kuszak, A. J., Edwald, E., Fung, J., Manglik, A., Masureel, M., Du, Y., Matt, R. A., Pardon, E., Steyaert, J., Kobilka, B. K. & Sunahara, R. K., 2016, In: Nature. 535, p. 182-6Research output: Contribution to journal › Letter › Research › peer-review
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Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assembly of a GPCR-G Protein Complex
Du, Y., Duc, N. M., Rasmussen, Søren Gøgsig Faarup, Hilger, D., Kubiak, X., Wang, L., Bohon, J., Kim, H. R., Wegrecki, M., Asuru, A., Jeong, K. M., Lee, J., Chance, M. R., Lodowski, D. T., Kobilka, B. K. & Chung, K. Y., 2019, In: Cell. 177, 5, p. 1232-1242Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter
Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723Research output: Contribution to journal › Journal article › Research › peer-review
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
Zocher, M., Zhang, C., Rasmussen, Søren Gøgsig Faarup, Kobilka, B. K. & Müller, D. J., 11 Dec 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. E3463–E3472Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational biosensors reveal GPCR signalling from endosomes
Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, Søren Gøgsig Faarup, Sunahara, R. K., El-Samad, H., Huang, B. & von Zastrow, M., 28 Mar 2013, In: Nature. 495, 7442, p. 534-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
Chung, K. Y., Rasmussen, Søren Gøgsig Faarup, Liu, T., Li, S., DeVree, B. T., Chae, P. S., Calinski, D., Kobilka, B. K., Woods, V. L. & Sunahara, R. K., 29 Sep 2011, In: Nature. 477, 7366, p. 611-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational dynamics of the human serotonin transporter during substrate and drug binding
Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.Research output: Contribution to journal › Journal article › Research › peer-review
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Correction to "tandem facial amphiphiles for membrane protein stabilization"
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 28 Aug 2013, In: Journal of the American Chemical Society. 135, 34, p. 12922 1 p.Research output: Contribution to journal › Journal article › Research
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Crystal Structures of the ß2-Adrenergic Receptor
Weis, W. I., Rosenbaum, D., Rasmussen, Søren Gøgsig Faarup & et. al, E. A., 2009, From Molecules to Medicines, Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Springer, p. 217-230 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor
Rasmussen, Søren Gøgsig Faarup, Choi, H., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., 15 Nov 2007, In: Nature. 450, 7168, p. 383-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the β2 adrenergic receptor-Gs protein complex
Rasmussen, Søren Gøgsig Faarup, DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, Jesper M., Shah, S. T. A., Lyons, J. A., Caffrey, M., Gellman, S. H., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 Sep 2011, In: Nature. 477, 7366, p. 549-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Developing an Assay to Probe Activtion and Conformational Dynamics of beta 2-Adrenergic Receptor on Single Molecule Level
Veshaguri, S., Tutkus, M., Lundgaard, C. V., Tonnesen, A., Mathiasen, Signe, Jorgensen, S. K., Iversen, L., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, 2, 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles
Kuszak, A. J., Yao, X. J., Rasmussen, Søren Gøgsig Faarup, Kobilka, B. & Sunahara, R. K., Dec 2010, G Protein-Coupled Receptors . Cambridge University Press, p. 32-52Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Yao, X., Weis, W. I., Stevens, R. C. & Kobilka, B. K., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1266-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1258-65 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of chromatophore membrane protein complexes formed under different nitrogen availability conditions in Rhodospirillum rubrum
Selao, T. T., Branca, R., Chae, P. S., Lehtiö, J., Gellman, S. H., Rasmussen, Søren Gøgsig Faarup, Nordlund, S. & Norén, A., 3 Jun 2011, In: Journal of Proteome Research. 10, 6, p. 2703-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 7932
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Ligand modulation of sidechain dynamics in a wild-type human GPCR
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Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
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Substrate-induced conformational dynamics of the dopamine transporter
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