Søren Gøgsig Faarup Rasmussen
Associate Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Bokoch, M. P., Zou, Y., Rasmussen, Søren Gøgsig Faarup, Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., 7 Jan 2010, In: Nature. 463, 7277, p. 108-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Tripod Amphiphiles for Membrane Protein Analysis
Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46Research output: Contribution to journal › Journal article › Research › peer-review
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Correction to "tandem facial amphiphiles for membrane protein stabilization"
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 28 Aug 2013, In: Journal of the American Chemical Society. 135, 34, p. 12922 1 p.Research output: Contribution to journal › Journal article › Research
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Tandem Facial Amphiphiles for Membrane Protein Stabilization
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S., Gether, Ulrik, Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Gellman, S. H., 27 Jul 2012, In: Chemistry: A European Journal. 18, 31, p. 9485-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, Søren Gøgsig Faarup, Thian, F. S., Kobilka, T. S., Choi, H., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., 23 Nov 2007, In: Science (New York, N.Y.). 318, 5854, p. 1258-65 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
Chung, K. Y., Rasmussen, Søren Gøgsig Faarup, Liu, T., Li, S., DeVree, B. T., Chae, P. S., Calinski, D., Kobilka, B. K., Woods, V. L. & Sunahara, R. K., 29 Sep 2011, In: Nature. 477, 7366, p. 611-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand modulation of sidechain dynamics in a wild-type human GPCR
Clark, L. D., Dikiy, I., Chapman, K., Rodstrom, K. E. J., Aramini, J., LeVine, M. V., Khelashvili, G., Rasmussen, Søren Gøgsig Faarup, Gardner, K. H. & Rosebaum, D. M., Oct 2017, In: eLife. 6, 27 p., e28505.Research output: Contribution to journal › Journal article › Research › peer-review
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A monoclonal antibody for G protein-coupled receptor crystallography
Day, P. W., Rasmussen, Søren Gøgsig Faarup, Parnot, C., Fung, J. J., Masood, A., Kobilka, T. S., Yao, X., Choi, H., Weis, W. I., Rohrer, D. K. & Kobilka, B. K., Nov 2007, In: Nature Methods. 4, 11, p. 927-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
DeVree, B. T., Mahoney, J. P., Vélez-Ruiz, G. A., Rasmussen, Søren Gøgsig Faarup, Kuszak, A. J., Edwald, E., Fung, J., Manglik, A., Masureel, M., Du, Y., Matt, R. A., Pardon, E., Steyaert, J., Kobilka, B. K. & Sunahara, R. K., 2016, In: Nature. 535, p. 182-6Research output: Contribution to journal › Letter › Research › peer-review
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Assembly of a GPCR-G Protein Complex
Du, Y., Duc, N. M., Rasmussen, Søren Gøgsig Faarup, Hilger, D., Kubiak, X., Wang, L., Bohon, J., Kim, H. R., Wegrecki, M., Asuru, A., Jeong, K. M., Lee, J., Chance, M. R., Lodowski, D. T., Kobilka, B. K. & Chung, K. Y., 2019, In: Cell. 177, 5, p. 1232-1242Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational biosensors reveal GPCR signalling from endosomes
Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, Søren Gøgsig Faarup, Sunahara, R. K., El-Samad, H., Huang, B. & von Zastrow, M., 28 Mar 2013, In: Nature. 495, 7442, p. 534-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
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Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes
Mathiasen, Signe, Christensen, S. M., Fung, J. J., Rasmussen, Søren Gøgsig Faarup, Fay, J. F., Jørgensen, S. K., Veshaguri, S., Farrens, D. L., Kiskowski, M., Kobilka, B. & Stamou, Dimitrios, 2014, In: Nature Methods. 11, p. 931-934 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Yeast surface display platform for rapid discovery of conformationally selective nanobodies
McMahon, C., Baier, A. S., Pascolutti, R., Wegrecki, M., Zheng, S., Ong, J. X., Erlandson, S. C., Hilger, D., Rasmussen, Søren Gøgsig Faarup, Ring, A. M., Manglik, A. & Kruse, A. C., 2018, In: Nature Structural and Molecular Biology. 25, 3, p. 289-296 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational dynamics of the human serotonin transporter during substrate and drug binding
Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate-Induced Conformational Dynamics of the Dopamine Transporter
Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Substrate-induced conformational dynamics of the dopamine transporter
Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 7932
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Ligand modulation of sidechain dynamics in a wild-type human GPCR
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
156
downloads
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
115
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Substrate-induced conformational dynamics of the dopamine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
Published