Kenneth Lindegaard Madsen
Associate Professor - Promotion Programme
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
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Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
Lund, Viktor Karlovich, Madsen, Kenneth Lindegaard & Kjærulff, Ole, 2018, In: Autophagy. 14, 9, p. 1520-1542 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.Research output: Contribution to journal › Journal article › Research › peer-review
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A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain
Jensen, Kathrine Louise, Noes-Holt, Gith, Sørensen, Andreas Toft & Madsen, Kenneth Lindegaard, 2021, In: Frontiers in Cellular Neuroscience. 15, 13 p., 750902.Research output: Contribution to journal › Journal article › Research › peer-review
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A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data
Ejdrup, Aske Lykke, Lycas, M. D., Lorenzen, N., Konomi Pilkati, Ainoa, Herborg, Freja, Madsen, Kenneth Lindegaard & Gether, Ulrik, 2022, In: Nature Communications. 13, 1, 4388.Research output: Contribution to journal › Journal article › Research › peer-review
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A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, , 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.Research output: Contribution to journal › Journal article › Research › peer-review
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A mechanistic overview of approaches for the treatment of psychostimulant dependence
Jensen, Kathrine Louise, Jensen, S. B. & Madsen, Kenneth Lindegaard, 2022, In: Frontiers in Pharmacology. 13, 22 p., 854176.Research output: Contribution to journal › Review › Research › peer-review
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AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons
Rathje, Mette, Fang, H., Bachman, J. L., Anggono, V., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 27 Aug 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14426-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats
Turner, C., De Luca, M., Wolfheimer, J., Hernandez, N., Madsen, Kenneth Lindegaard & Schmidt, H. D., 2020, In: Neuropharmacology. 164, 107901.Research output: Contribution to journal › Journal article › Research › peer-review
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Amphipathic motifs in BAR domains are essential for membrane curvature sensing
Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In: EMBO Journal. 28, 21, p. 3303-3314 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1
Jensen, Rasmus Herlo Beenfeldt, Lund, Viktor Karlovich, Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., qrc243, qrc243, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature
Madsen, Kenneth Lindegaard, Bhatia, V. K., Gether, Ulrik & Stamou, Dimitrios, 2010, In: FEBS Letters. 584, 9, p. 1848-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Behavioral encoding across timescales by region-specific dopamine dynamics
Jørgensen, Søren Heide, Ejdrup, Aske Lykke, Lycas, M. D., Posselt, Leonie Pauline, Madsen, Kenneth Lindegaard, Tian, L., Dreyer, J. K., Herborg, Freja, Sørensen, Andreas Toft & Gether, Ulrik, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, 10 p., e2215230120.Research output: Contribution to journal › Journal article › Research › peer-review
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Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners
Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.Research output: Contribution to journal › Journal article › Research › peer-review
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Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis
Andersen, R. C., Schmidt, J. H., Rombach, J., Lycas, M. D., Christensen, N. R., Lund, V. K., Stapleton, D. S., Pedersen, S. S., Olsen, M. A., Stoklund, M., Noes-Holt, G., Nielsen, T. T. E., Keller, M. P., Jansen, A. M., Herlo, R., Pietropaolo, M., Simonsen, J. B., Kjærulff, O., Holst, B., Attie, A. D. & 2 others, , 2022, In: Journal of Clinical Investigation. 132, 5, e144904.Research output: Contribution to journal › Journal article › Research › peer-review
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Constitutive internalization across therapeutically targeted GPCRs correlates with constitutive activity
Schmidt, Jan Hendrik, Perslev, Mathias, Bukowski, L., Stoklund, M., Herborg, Freja, Herlo, R. & Madsen, Kenneth Lindegaard, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 116-121 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes
Falk-Petersen, C. B., Søgaard, R., Madsen, Kenneth Lindegaard, Klein, A. B., Frølund, Bente & Wellendorph, Petrine, Aug 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 2, p. 119-129 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons
Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini
Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species
Skamris, T., Marasini, C., Madsen, Kenneth Lindegaard, Foderà, Vito & Vestergaard, Bente, 2019, In: Scientific Reports. 9, p. 1-11 11 p., 1733.Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins
Kasaragod, V. B., Hausrat, T. J., Schaefer, N., Kuhn, M., Christensen, N. R., Tessmer, I., Maric, H. M., Madsen, Kenneth Lindegaard, Sotriffer, C., Villmann, C., Kneussel, M. & Schindelin, H., 2019, In: Neuron. 101, 4, p. 673-689 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1
Søgaard, R., Borre, L., Braunstein, T. H., Madsen, Kenneth Lindegaard & MacAulay, Nanna, 12 Jul 2013, In: The Journal of Biological Chemistry. 288, 28, p. 20195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GABA(A) receptor function is regulated by lipid bilayer elasticity
Søgaard, R., Werge, T. M., Bertelsen, C., Lundbye, C., Madsen, Kenneth Lindegaard, Nielsen, Claus Henrik & Lundbaek, J. A., 2006, In: Biochemistry. 45, 43, p. 13118-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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How curved membranes recruit amphipathic helices and protein anchoring motifs
Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils
Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In: European Journal of Neuroscience. 27, 1, p. 66-82 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets
qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane Binding and Modulation of the PDZ Domain of PICK1
qrc243, qrc243 & Madsen, Kenneth Lindegaard, Dec 2015, In: Membranes. 5, 4, p. 597-615 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Membrane localization is critical for activation of the PICK1 BAR domain
Madsen, Kenneth Lindegaard, Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., Ammendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-43 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.
Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system
Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway
Madsen, Kenneth Lindegaard, Thorsen, T. S., Rahbek-Clemmensen, T., Eriksen, J. M. & Gether, Ulrik, 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12293-308 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands
qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recursive Alterations of the Relationship between Simple Membrane Geometry and Insertion of Amphiphilic Motifs
Madsen, Kenneth Lindegaard & Jensen, Rasmus Herlo Beenfeldt, 2017, In: Membranes. 7, 1, 19 p., 7010006.Research output: Contribution to journal › Review › Research › peer-review
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Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling
Rathje, Mette, Fang, H., Bachman, J. L., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to the challenges of Polydisperse SAXS data analysis: two different SAXS studies of PICK1 produce different structural models
qrc243, qrc243, Arleth, Lise & Madsen, Kenneth Lindegaard, 2015, In: Structure. 23, 11, p. 1969-1970 2 p.Research output: Contribution to journal › Letter › Research › peer-review
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Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding
Ammendrup-Johnsen, I., Thorsen, T. S., Gether, Ulrik & Madsen, Kenneth Lindegaard, 17 Jan 2012, In: Biochemistry. 51, 2, p. 586-96 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Striatal neurons get a kick out of dopamine
Madsen, Kenneth Lindegaard & Dreyer, J. K., Dec 2017, In: Journal of Physiology. 595, 24, p. 7271-7272 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering
Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Supported Cell Membrane Sheets to Monitor Protein Assembly
qrc243, qrc243, Thorsen, T. S. & Madsen, Kenneth Lindegaard, 2019, In: Bio-protocol. 9, 18Research output: Contribution to journal › Journal article › Research › peer-review
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Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions
Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Apuschkin, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, , 2024, In: Science Advances. 10, 9, 20 p., eadg2636.Research output: Contribution to journal › Journal article › Research › peer-review
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The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells
da Silva Pinheiro, P. C., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, Kenneth Lindegaard, Verhage, M., Gether, Ulrik & Sørensen, Jakob Balslev, 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32, p. 10688-700 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway
Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926Research output: Contribution to journal › Journal article › Research › peer-review
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ID: 6404
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
286
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A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
226
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Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
Research output: Contribution to journal › Journal article › Research › peer-review
Published