Jens D. Mikkelsen

Jens D. Mikkelsen

Professor


  1. Published

    Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs

    Abrams, J. K., Johnson, P. L., Hay-Schmidt, Anders, Mikkelsen, Jens D., Shekhar, A. & Lowry, C. A., 2005, In: Neuroscience. 133, 4, p. 983-97 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    N1H- and N1-Substituted Phenylguanidines as alpha 7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies

    Alwassil, O., Khatri, S., Schulte, M. K., Aripaka, S. S., Mikkelsen, Jens D. & Dukat, M., 2021, In: ACS Chemical Neuroscience. 12, 12, p. 2194-2201 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells

    trj450, trj450 & Mikkelsen, Jens D., 2022, In: Neuroimmunomodulation. 27, 4, p. 194-202 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion

    Aripaka, S. S., jmn329, jmn329, Jørgensen, Louise Møller, Chughtai, S. A., Gaarde, C., Bendix, T. & Mikkelsen, Jens D., 2021, In: European Spine Journal. 30, p. 2967–2974 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome

    trj450, trj450, jmn329, jmn329, Jørgensen, Louise Møller & Mikkelsen, Jens D., 2023, In: Molecular and Cellular Biochemistry. 478, 1, p. 121-130 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Functional interaction between Lypd6 and nicotinic acetylcholine receptors

    Arvaniti, M., Jensen, M. M., Soni, N., Wang, H., Klein, A. B., Thiriet, N., Pinborg, Lars Hageman, Muldoon, P. P., Wienecke, Jacob, Imad Damaj, M., Kohlmeier, Kristi Anne, Gondré-Lewis, M. C., Mikkelsen, Jens D. & Thomsen, M. S., Sep 2016, In: Journal of Neurochemistry. 138, 6, p. 806-820 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Photoperiodic Co-Regulation of Kisspeptin, Neurokinin B and Dynorphin in the Hypothalamus of a Seasonal Rodent

    Bartzen-Sprauer, J., Klosen, P., Ciofi, P., Mikkelsen, Jens D. & Simonneaux, V., Aug 2014, In: Journal of Neuroendocrinology. 26, 8, p. 510-520 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus

    Bendová, Z., Sumová, A. & Mikkelsen, Jens D., 2009, In: Neuroscience. 159, 2, p. 599-609 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study

    Bertelsen, B., Oranje, B., Melchior, L., Fagerlund, Birgitte, Werge, Thomas, Mikkelsen, Jens D., Tümer, Asuman Zeynep & Glenthøj, Birte Yding, Dec 2015, In: NeuroMolecular Medicine. 17, 4, p. 423-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Association of the CHRNA7 promoter variant −86T with Tourette syndrome and comorbid obsessive-compulsive disorder

    Bertelsen, B., Melchior, L., Tümer, Asuman Zeynep, Groth, C., Mol Debes, N., Skov, L., Holst, K. K., Fagerlund, Birgitte & Mikkelsen, Jens D., 30 Nov 2014, In: Psychiatry Research. 219, 3, p. 710-711 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  11. Published

    Quantification of the functional expression of the Ca2+‐activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

    Blomster, L. V., Strøbaek, D., Hougaard, Charlotte Ørsted, Klein, J., Pinborg, Lars Hageman, Mikkelsen, Jens D. & Christophersen, P., Dec 2016, In: Glia. 64, 12, p. 2065-2078 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Localized infusions of the partial alpha 7 nicotinic receptor agonist SSR180711 evoke rapid and transient increases in prefrontal glutamate release

    Bortz, D. M., Mikkelsen, Jens D. & Bruno, J. P., 2013, In: Neuroscience. 255, p. 55-67

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood

    Bortz, D. M., Jørgensen, C. V., Mikkelsen, Jens D. & Bruno, J. P., Sep 2014, In: Neuropharmacology. 84, p. 19-30 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

    Bortz, D. M., Upton, B. A., Mikkelsen, Jens D. & Bruno, J. P., Dec 2016, In: Neuropharmacology. 111, p. 78-91

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

    Brindisi, M., Butini, S., Franceschini, S., Brogi, S., Trotta, F., Ros, S., Cagnotto, A., Salmona, M., Casagni, A., Andreassi, M., Saponara, S., Gorelli, B., Weikop, P., Mikkelsen, Jens D., Scheel-Kruger, J., Sandager-Nielsen, K., Novellino, E., Campiani, G. & Gemma, S., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9578-9597 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Transient inactivation of the neonatal ventral hippocampus impairs attentional set-shifting behavior: reversal with an α7 nicotinic agonist

    Brooks, J. M., Pershing, M. L., Thomsen, M. S., Mikkelsen, Jens D., Sarter, M. & Bruno, J. P., Oct 2012, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 37, 11, p. 2476-86 11 p.

    Research output: Contribution to journalJournal articleResearch

  17. Published

    Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats

    Bundzikova, J., Pirnik, Z., Zelena, D., Kiss, A. & Mikkelsen, Jens D., 2008, In: Cellular & Molecular Neurobiology. 28, 8, p. 1033-1047 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation

    Burmester, D. R., Madsen, M. K., Szabo, A., trj450, trj450, Stenbæk, Dea Siggaard, Frøkjær, Vibe Gedsø, Elfving, B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Fisher, Patrick Mac Donald, 2023, In: Comprehensive Psychoneuroendocrinology. 13, 7 p., 100163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

    Butini, S., Gemma, S., Campiani, G., Franceschini, S., Trotta, F., Borriello, M., Ceres, N., Ros, S., Coccone, S. S., Bernetti, M., De Angelis, M., Brindisi, M., Nacci, V., Fiorini, I., Novellino, E., Cagnotto, A., Mennini, T., Sandager-Nielsen, K., Andreasen, J. T., Scheel-Kruger, J. & 2 others, Mikkelsen, Jens D. & Fattorusso, C., 2009, In: Journal of Medicinal Chemistry. 52, 1, p. 151-69 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

    Christensen, D. Z., Thomsen, M. S. & Mikkelsen, Jens D., Jul 2013, In: Neurochemistry International. 63, 1, p. 54-60 7 p.

    Research output: Contribution to journalJournal articleResearch

  21. Published

    Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

    Donat, C. K., Gaber, K., Meixensberger, J., Brust, P., Pinborg, Lars Hageman, Hansen, H. H. & Mikkelsen, Jens D., Jun 2016, In: NeuroMolecular Medicine. 18, 2, p. 158-69 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    In vitro and in vivo characterization of dibenzothiophene derivatives [125I]iodo-ASEM and [18F]ASEM as radiotracers of homo- And heteromeric α7 nicotinic acetylcholine receptors

    Donat, C. K., Hansen, H. H., Hansen, H. D., Mease, R. C., Horti, A. G., Pomper, M. G., L’Estrade, E. T., Herth, Matthias Manfred, Peters, D., Knudsen, Gitte Moos & Mikkelsen, Jens D., 1 Jan 2020, In: Molecules. 25, 6, 19 p., 1425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.

    Dyrvig, M., Hansen, H. H., Christiansen, S. H. O., Woldbye, David Paul Drucker, Mikkelsen, Jens D. & Lichota, J., 2012, In: Brain Research Bulletin. 88, p. 507-13 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

    Dyrvig, M., Mikkelsen, Jens D. & Lichota, J., Jun 2019, In: Neuroscience Letters. 704, p. 145-152

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging: A test-retest study

    Feng, L., Jensen, P., Thomsen, G., Dyssegaard, A., Svarer, C., Knudsen, L. V., Møller, Kirsten, Thomsen, C., Mikkelsen, Jens D., Guilloteau, D., Knudsen, Gitte Moos & Pinborg, Lars Hageman, 2017, In: Journal of Nuclear Medicine. 58, 6, p. 989-995 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels

    Fisher, Patrick Mac Donald, Holst, K. K., Adamsen, D., Klein, A. B., Frøkjær, Vibe Gedsø, Jensen, P. S., Svarer, C., Gillings, N., Baare, W. F. C., Mikkelsen, Jens D. & Knudsen, G. M., Jan 2015, In: Human Brain Mapping. 36, 1, p. 313–323 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Aβ Induces Cell Death in Pc12 Cells and Tau-Transfected Cho Cells, but only Tau Phosphorylation in Pc12 Cells

    Fjord-Larsen, L., Mikkelsen, Jens D. & Olesen, O. F., 1998, Progress in Alzheimer’s and Parkinson’s Diseases . p. 257-263 7 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats

    Frimer, N. A., Overgaard, A., Lie, M. E. K., Mikkelsen, Jens D. & Frokjaer, V. G., 2015, In: Journal of Steroids & Hormonal Science. 6, 3, p. 1-5 5 p., 1000161.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

    Frokjaer, V. G., Pinborg, Anja, Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., Stenbæk, D. S., da Cunha-Bang, S., Lehel, S., Siebner, Hartwig Roman, Mikkelsen, Jens D., Svarer, C. & Knudsen, Gitte Moos, 15 Oct 2015, In: Biological Psychiatry. 78, 8, p. 534-43 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

    Hansen, H. H., Fabricius, K., Barkholt, P., Mikkelsen, Jens D., Jelsing, J., Pyke, C., Knudsen, L. B. & Vrang, N., 1 Sep 2016, In: Brain Research. 1646, p. 354-365 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    Hansen, H. H., Jensen, M. M., Overgaard, A., Weikop, Pia & Mikkelsen, Jens D., 2013, In: Pharmacology, Biochemistry and Behavior. 110, p. 265-271 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

    Hansen, H. H., Weikop, P., Mikkelsen, M. D., Rode, F. & Mikkelsen, Jens D., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 120, 1, p. 46-51 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

    Henningsen, J. B., Poirel, V., Mikkelsen, Jens D., Tsutsui, K., Simonneaux, V. & Gauer, F., 15 Jun 2016, In: Journal of Comparative Neurology. 524, 9, p. 1825-1838 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 2017, In: Endocrinology. 158, 3, p. 652-663

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

    Hervig, M. E., Thomsen, M. S., Kalló, I. & Mikkelsen, Jens D., 15 Oct 2016, In: Neuroscience. 334, p. 13-25 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice

    Holm, P., Ettrup, A., Klein, A. B., Santini, M. A., El-Sayed, M., Elvang, A. B., Stensbøl, T. B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Kleijn, S. A., 1 Jan 2010, In: Journal of Alzheimer's Disease. 20, 4, p. 1201-13 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

    Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, Jens D. & Mirza, N. R., 2009, In: Neuroscience. 163, 1, p. 73-81 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Distribution and seasonal variation in hypothalamic RF-amide peptides in a semi-desert rodent, the jerboa

    Janati, A., Talbi, R., Klosen, P., Mikkelsen, Jens D., Magoul, R., Simonneaux, V. & El Ouezzani, S., 2013, In: Journal of Neuroendocrinology. 25, 4, p. 402-411 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

    Jennings, K. J., Chasles, M., Cho, H., Mikkelsen, Jens D., Bentley, G., Keller, M. & Kriegsfeld, L. J., Nov 2017, In: Integrative and Comparative Biology. 57, 5, p. 1055-1065 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease

    Jensen, M. M., Mikkelsen, Jens D., Arvaniti, M., Pinborg, Lars Hageman & Thomsen, M. S., 1 Apr 2015, In: Neurobiology of Aging. 36, 4, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

    Jensen, P., Feng, L., Law, Ian, Svarer, C., Knudsen, G. M., Mikkelsen, Jens D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D. & Pinborg, Lars Hageman, Sep 2015, In: Journal of Nuclear Medicine. 56, 9, p. 1386-90 5 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  43. Published

    Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    Jorgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, Jens D., Fink-Jensen, Anders, Knudsen, G. M., Paulson, Olaf B., Bolwig, T. G. & Jørgensen, Martin Balslev, Feb 2016, In: Acta Psychiatrica Scandinavica. 133, 2, p. 154-164 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice

    Jørgensen, C. V., Jacobsen, J. P., Caron, M. G., Klein, A. B., Knudsen, Gitte Moos & Mikkelsen, Jens D., 25 Oct 2013, In: Neuroscience Letters. 555, p. 118-22 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons

    Jørgensen, C. V., Klein, A. B., El-Sayed, M., Knudsen, G. M. & Mikkelsen, Jens D., 2013, In: Synapse. 67, 11, p. 794-800

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle

    Jørgensen, S. R., Andersen, M. D., Overgaard, A. & Mikkelsen, Jens D., Nov 2014, In: Endocrinology. 155, 11, p. 4402-4410 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains

    Klein, A. B., Ultved, L., Adamsen, D., Santini, M. A., Tobeña, A., Fernandez-Teruel, A., Flores, P., Moreno, M., Cardona, D., Knudsen, Gitte Moos, Aznar, S. & Mikkelsen, Jens D., 28 Mar 2014, In: Neuroscience. 263, p. 36-45 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

    Klein, A. B., Jennum, Poul, Knudsen, S., Gammeltoft, S. & Mikkelsen, Jens D., 7 Jun 2013, In: Neuroscience Letters. 544, p. 31-35 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat

    Kristensen, S., Thomsen, M. S., Hansen, H. H., Timmermann, D. B., Hay-Schmidt, Anders & Mikkelsen, Jens D., 17 May 2007, In: Neuroscience Letters. 418, 2, p. 154-8 5 p.

    Research output: Contribution to journalJournal articleResearch

  50. Published

    Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons

    Larsen, H. M., Hansen, S. K., Mikkelsen, Jens D., Hyttel, P. & Stummann, T. C., 2019, In: Stem Cell Research. 41, 10 p., 101642.

    Research output: Contribution to journalJournal articleResearchpeer-review

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