Jens D. Mikkelsen

Jens D. Mikkelsen

Professor

ORCID: 0000-0002-0498-6861

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  1. Published

    α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

    Thomsen, M. S., Zwart, R., Ursu, D., Jensen, M. M., Pinborg, Lars Hageman, Gilmour, G., Wu, J., Sher, E. & Mikkelsen, Jens D., 2015, In: PLOS ONE. 10, 6, p. 1-16 16 p., e0130572.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment

    Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P. & Mikkelsen, Jens D., 2009, In: Neuropharmacology. 56, 6-7, p. 1001-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

    Thomsen, M. S. & Mikkelsen, Jens D., Oct 2012, In: Journal of Neurochemistry. 123, 1, p. 73-83 11 p.

    Research output: Contribution to journal › Journal article › Research

  4. Published

    Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome

    trj450, trj450, jmn329, jmn329, Jørgensen, Louise Møller & Mikkelsen, Jens D., 2023, In: Molecular and Cellular Biochemistry. 478, 1, p. 121-130 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood

    Bortz, D. M., Jørgensen, C. V., Mikkelsen, Jens D. & Bruno, J. P., Sep 2014, In: Neuropharmacology. 84, p. 19-30 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Transient inactivation of the neonatal ventral hippocampus impairs attentional set-shifting behavior: reversal with an α7 nicotinic agonist

    Brooks, J. M., Pershing, M. L., Thomsen, M. S., Mikkelsen, Jens D., Sarter, M. & Bruno, J. P., Oct 2012, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 37, 11, p. 2476-86 11 p.

    Research output: Contribution to journal › Journal article › Research

  7. Published

    The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

    Thomsen, M. S. & Mikkelsen, Jens D., 15 Oct 2012, In: Journal of Neuroimmunology. 251, 1-2, p. 65-72 8 p.

    Research output: Contribution to journal › Journal article › Research

  8. Published

    The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets?

    Thomsen, M. S. & Mikkelsen, Jens D., May 2012, In: Current Drug Targets. 13, 5, p. 707-20 14 p.

    Research output: Contribution to journal › Journal article › Research

  9. Published

    The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging: A test-retest study

    Feng, L., Jensen, P., Thomsen, G., Dyssegaard, A., Svarer, C., Knudsen, L. V., Møller, Kirsten, Thomsen, C., Mikkelsen, Jens D., Guilloteau, D., Knudsen, Gitte Moos & Pinborg, Lars Hageman, 2017, In: Journal of Nuclear Medicine. 58, 6, p. 989-995 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat

    Thomsen, M. S., Mikkelsen, Jens D., Timmermann, D. B., Peters, D. A., Hay-Schmidt, Anders, Martens, H. A., Hansen, H. H. & Thomsen, M. S., 23 Jun 2008, In: Neuroscience. 154, 2, p. 741-53 13 p.

    Research output: Contribution to journal › Journal article › Research

  11. Published

    The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

    Hansen, H. H., Weikop, P., Mikkelsen, M. D., Rode, F. & Mikkelsen, Jens D., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 120, 1, p. 46-51 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42

    Søderman, A., Thomsen, M. S., Hansen, H. H., Nielsen, E. Ø., Jensen, M. S., West, M. J. & Mikkelsen, Jens D., 28 Aug 2008, In: Brain Research. 1227, p. 240-7 8 p.

    Research output: Contribution to journal › Journal article › Research

  13. Published

    The neuroanatomy of the kisspeptin system in the mammalian brain

    Mikkelsen, Jens D. & Simonneaux, V., 2008, In: Peptides. 30, 1, p. 26-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

    Menezes, M. M., Santini, M., Benvega, M. J., Marek, G. J., Merchant, K. M., Mikkelsen, Jens D. & Svensson, K. A., 2013, In: Neuroscience Journal. 2013, 8 p., 736439.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus

    Overgaard, A., Holst, K., Mandrup, K., Boberg, J., Christiansen, S., Jacobsen, A. P., Hass, U. & Mikkelsen, Jens D., 2013, In: NeuroToxicology. 37, p. 154-162 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat

    Kristensen, S., Thomsen, M. S., Hansen, H. H., Timmermann, D. B., Hay-Schmidt, Anders & Mikkelsen, Jens D., 17 May 2007, In: Neuroscience Letters. 418, 2, p. 154-8 5 p.

    Research output: Contribution to journal › Journal article › Research

  17. Published

    The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

    Jennings, K. J., Chasles, M., Cho, H., Mikkelsen, Jens D., Bentley, G., Keller, M. & Kriegsfeld, L. J., Nov 2017, In: Integrative and Comparative Biology. 57, 5, p. 1055-1065 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The Cholinergic but not the Serotonergic Phenotype of Anew Neuronal Cell Line is Sensitive to β-Amyloid-Induced Toxicity

    Olesen, O. F., Fjord-Larsen, L. & Mikkelsen, Jens D., 1998, Progress in Alzheimer’s and Parkinson’s Diseases . p. 495-501 7 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  19. Published

    Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    Hansen, H. H., Jensen, M. M., Overgaard, A., Weikop, Pia & Mikkelsen, Jens D., 2013, In: Pharmacology, Biochemistry and Behavior. 110, p. 265-271 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study

    Pazarlar, B. A., Madsen, C. A., Oyar, E. Ö., Eğilmez, C. B. & Mikkelsen, Jens D., 2022, In: Epilepsy Research. 183, 10 p., 106926.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

    Brindisi, M., Butini, S., Franceschini, S., Brogi, S., Trotta, F., Ros, S., Cagnotto, A., Salmona, M., Casagni, A., Andreassi, M., Saponara, S., Gorelli, B., Weikop, P., Mikkelsen, Jens D., Scheel-Kruger, J., Sandager-Nielsen, K., Novellino, E., Campiani, G. & Gemma, S., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9578-9597 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

    Jensen, P., Feng, L., Law, Ian, Svarer, C., Knudsen, G. M., Mikkelsen, Jens D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D. & Pinborg, Lars Hageman, Sep 2015, In: Journal of Nuclear Medicine. 56, 9, p. 1386-90 5 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  23. Published

    Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke

    Thougaard, E., Nielsen, P. V., Forsberg, A., Phuong, V., Velasco, A. M., Wlodarczyk, A., Wajant, H., Lang, I., Mikkelsen, Jens D., Clausen, B. H., Brambilla, R. & Lambertsen, K. L., 2023, In: Journal of Neuroimmunology. 385, 17 p., 578246.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

    Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, Jens D. & Hansen, J. B., 2022, In: Experimental Neurology. 358, 12 p., 114209.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

    Mikkelsen, Jens D., Kaad, S., trj450, trj450 & Finsen, Bente, 2023, In: Neurobiology of Aging. 129, p. 50-57 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

    Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, Ida Vang, Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, Jens D., Fisher, P. M. D., Herth, Matthias Manfred, Plavén-Sigray, P., Knudsen, Gitte Moos & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation

    Burmester, D. R., Madsen, M. K., Szabo, A., trj450, trj450, Stenbæk, Dea Siggaard, Frøkjær, Vibe Gedsø, Elfving, B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Fisher, Patrick Mac Donald, 2023, In: Comprehensive Psychoneuroendocrinology. 13, 7 p., 100163.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain

    Mikkelsen, Jens D., trj450, trj450, Bascuñana, P., Bankstahl, M., Bankstahl, J. P. & Pazarlar, B. A., 2022, In: Neuroscience. 499, p. 142-151 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

    Henningsen, J. B., Poirel, V., Mikkelsen, Jens D., Tsutsui, K., Simonneaux, V. & Gauer, F., 15 Jun 2016, In: Journal of Comparative Neurology. 524, 9, p. 1825-1838 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs

    Abrams, J. K., Johnson, P. L., Hay-Schmidt, Anders, Mikkelsen, Jens D., Shekhar, A. & Lowry, C. A., 2005, In: Neuroscience. 133, 4, p. 983-97 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors

    Mikkelsen, Jens D., Hay-Schmidt, Anders & Kiss, A., Jun 2004, In: Annals of the New York Academy of Sciences. 1018, p. 65-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

    Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, Jens D. & Mirza, N. R., 2009, In: Neuroscience. 163, 1, p. 73-81 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 2017, In: Endocrinology. 158, 3, p. 652-663

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

    Frokjaer, V. G., Pinborg, Anja, Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., Stenbæk, D. S., da Cunha-Bang, S., Lehel, S., Siebner, Hartwig Roman, Mikkelsen, Jens D., Svarer, C. & Knudsen, Gitte Moos, 15 Oct 2015, In: Biological Psychiatry. 78, 8, p. 534-43 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats

    Bundzikova, J., Pirnik, Z., Zelena, D., Kiss, A. & Mikkelsen, Jens D., 2008, In: Cellular & Molecular Neurobiology. 28, 8, p. 1033-1047 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Reprogrammering af modne celler til neuroner

    Mikkelsen, Jens D., Rasmussen, M. A., Meyer, M. & Knudsen, G. M., 2012, In: Ugeskrift for Laeger. 174, 12, p. 786

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

    Larsen, M. H., Mikkelsen, Jens D., Hay-Schmidt, Anders & Sandi, C., 2010, In: Journal of Psychiatric Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    Jorgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, Jens D., Fink-Jensen, Anders, Knudsen, G. M., Paulson, Olaf B., Bolwig, T. G. & Jørgensen, Martin Balslev, Feb 2016, In: Acta Psychiatrica Scandinavica. 133, 2, p. 154-164 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

    Christensen, D. Z., Thomsen, M. S. & Mikkelsen, Jens D., Jul 2013, In: Neurochemistry International. 63, 1, p. 54-60 7 p.

    Research output: Contribution to journal › Journal article › Research

  41. Published

    Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

    Magnussen, J. H., Ettrup, A., Donat, C. K., Peters, D., Pedersen, M. H. F., Knudsen, G. M. & Mikkelsen, Jens D., 5 Sep 2015, In: European Journal of Pharmacology. 762, p. 35-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Quantification of the functional expression of the Ca2+‐activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

    Blomster, L. V., Strøbaek, D., Hougaard, Charlotte Ørsted, Klein, J., Pinborg, Lars Hageman, Mikkelsen, Jens D. & Christophersen, P., Dec 2016, In: Glia. 64, 12, p. 2065-2078 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease

    Jensen, M. M., Mikkelsen, Jens D., Arvaniti, M., Pinborg, Lars Hageman & Thomsen, M. S., 1 Apr 2015, In: Neurobiology of Aging. 36, 4, p. 1629-1638 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

    Bortz, D. M., Upton, B. A., Mikkelsen, Jens D. & Bruno, J. P., Dec 2016, In: Neuropharmacology. 111, p. 78-91

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice

    Holm, P., Ettrup, A., Klein, A. B., Santini, M. A., El-Sayed, M., Elvang, A. B., Stensbøl, T. B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Kleijn, S. A., 1 Jan 2010, In: Journal of Alzheimer's Disease. 20, 4, p. 1201-13 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Photoperiodic Co-Regulation of Kisspeptin, Neurokinin B and Dynorphin in the Hypothalamus of a Seasonal Rodent

    Bartzen-Sprauer, J., Klosen, P., Ciofi, P., Mikkelsen, Jens D. & Simonneaux, V., Aug 2014, In: Journal of Neuroendocrinology. 26, 8, p. 510-520 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

    Wichern, F., Jensen, M. M., Christensen, D. Z., Mikkelsen, Jens D., Gondré-Lewis, M. C. & Thomsen, M. S., 27 Mar 2017, In: Neuroscience. 346, p. 278-283 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats

    Frimer, N. A., Overgaard, A., Lie, M. E. K., Mikkelsen, Jens D. & Frokjaer, V. G., 2015, In: Journal of Steroids & Hormonal Science. 6, 3, p. 1-5 5 p., 1000161.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Neuropeptide Y (NPY) and NPY receptors in the rat pineal gland

    Mikkelsen, Jens D., Hauser, Frank & Olcese, J., 1999, In: Advances in Experimental Medicine and Biology. 460, p. 95-107 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    N1H- and N1-Substituted Phenylguanidines as alpha 7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies

    Alwassil, O., Khatri, S., Schulte, M. K., Aripaka, S. S., Mikkelsen, Jens D. & Dukat, M., 2021, In: ACS Chemical Neuroscience. 12, 12, p. 2194-2201 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 32177473