Claus Juul Løland
Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
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Preface: Special issue on neurotransmitter transporters
Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.Research output: Contribution to journal › Editorial › Research › peer-review
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Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster
Pugh, Ciara Frances, DeVree, B. T., Schmidt, S. G. & Loland, Claus Juul, 2022, In: Cells. 11, 23, 15 p., 3811.Research output: Contribution to journal › Journal article › Research › peer-review
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Persistent binding at dopamine transporters determines sustained psychostimulant effects
Niello, M., Sideromenos, S., Gradisch, R., O'Shea, R., Schwazer, J., Maier, J., Kastner, N., Sandtner, W., Jäntsch, K., Lupica, C. R., Hoffman, A. F., Lubec, G., Loland, Claus Juul, Stockner, T., Pollak, D. D., Baumann, M. H. & Sitte, H. H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, 11 p., e2114204120.Research output: Contribution to journal › Journal article › Research › peer-review
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Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization
Bae, H. E., Cecchetti, C., Du, Y., Katsube, S., Mortensen, Jonas Sigurd, Huang, W., Rehan, S., Lee, H. J., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2020, In: Acta Biomaterialia. 112, p. 250-261 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017Research output: Other contribution › Research
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Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors
Cao, J., Slack, R. D., Bakare, O. M., Burzynski, C., Rais, R., Slusher, B. S., Kopajtic, T., Bonifazi, A., Ellenberger, M. P., Yano, H., He, Y., Bi, G., Xi, Z., Loland, Claus Juul & Newman, A. H., 8 Dec 2016, In: Journal of Medicinal Chemistry. 59, 23, p. 10676-10691 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation
Cho, K. H., Du, Y., Scull, N. J., Hariharan, P., Gotfryd, K., Loland, Claus Juul, Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2015, In: Chemistry: A European Journal. 21, 28, p. 10008–10013 6 p.Research output: Contribution to journal › Letter › Research › peer-review
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Novel Tripod Amphiphiles for Membrane Protein Analysis
Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46Research output: Contribution to journal › Journal article › Research › peer-review
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New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability
Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neurotransmitter transporters: structure and function
Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Neurotransmitter Transporters: Structure, Function, and Drug Binding
Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.
Sørensen, G., Jensen, M., Weikop, Pia, Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile
Okorom, A. V., Camacho-Hernandez, G. A., Salomon, Kristine Walløe, Lee, K. H., Ku, T. C., Cao, J., Won, S. J., Friedman, J., Lam, J., Paule, J., Rais, R., Klein, B., Xi, Z. X., Shi, L., Loland, Claus Juul & Newman, A. H., 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 709-727 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, , 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy
Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Markham, K., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 Dec 2016, In: Chemistry: A European Journal. 22, 52, p. 18833–18839Research output: Contribution to journal › Journal article › Research › peer-review
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Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance
Ghani, L., Kim, S., Ehsan, M., Lan, B., Poulsen, I. H., Dev, C., Katsube, S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X., Im, W. & Chae, P. S., 2023, In: Chemical Science. 14, 45, 11 p., 13014.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability
Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study
Cho, K. H., Husri, M., Amin, A., Gotfryd, K., Lee, H. J., Go, J., Kim, J. W., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 2015, In: The Analyst. 140, 9, p. 3157-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length
Cho, K. H., Hariharan, P., Mortensen, Jonas Sigurd, Du, Y., Nielsen, A. K., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 14 Dec 2016, In: ChemBioChem. 17, 24, p. 2334–2339Research output: Contribution to journal › Journal article › Research › peer-review
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Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding
Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38Research output: Contribution to journal › Journal article › Research › peer-review
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Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters
Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments
Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies
Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, Jonas Sigurd, Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 Mar 2016, In: Journal of the American Chemical Society. 138, 11, p. 3789-3796 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Jagalski, V., Barker, R. D., Thygesen, Mikkel Boas, Gotfryd, K., Krüger, M. B., Shi, L., Maric, S., Bovet, N. E., Moulin, M., Haertlein, M., Pomorski, Thomas Guenther, Loland, Claus Juul & Cardenas Gomez, M., 2015, In: Soft Matter. 11, 39, p. 7707-7711 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study
Ehsan, M., Wang, H., Katsube, S., Munk, C. F., Du, Y., Youn, T., Yoon, S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2022, In: ChemBioChem. 23, 7, e202200027.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8Research output: Contribution to journal › Journal article › Research › peer-review
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Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization
Ghani, L., Kim, S., Wang, H., Lee, H. S., Mortensen, Jonas Sigurd, Katsube, S., Du, Y., Sadaf, A., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W., Chae, P. S. & Ahmed, W., 2022, In: Chemistry: A European Journal. 28, 21, 9 p., e202200116.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring the K+ binding site and its coupling to transport in the neurotransmitter: sodium symporter LeuT
Schmidt, S. G., Nygaard, Andreas, Mindell, J. A. & Loland, Claus Juul, 2024, In: eLife. 12, 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents
MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues
Okunola-Bakara, O., Cao, J., Kopajtic, T., Katz, J. L., Loland, Claus Juul, Shi, L. & Newman, A. H., 2014, In: Journal of Medicinal Chemistry. 57, 3, p. 1000-1013 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution
Schmidt, S. G., Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors
Salomon, K., Abramyan, A. M., Plenge, P., Wang, L., Bundgaard, C., Bang-Andersen, B., Loland, Claus Juul & Shi, L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 41, 10 p., e2304089120.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
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Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study
Das, M., Mahler, F., Hariharan, P., Wang, H., Du, Y., Mortensen, Jonas Sigurd, Patallo, E. P., Ghani, L., Glück, D., Lee, H. J., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K., Keller, S. & Chae, P. S., 2020, In: Journal of the American Chemical Society. 142, 51, p. 21382–21392 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study
Lee, H. J., Ehsan, M., Zhang, X., Katsube, S., Munk, C. F., Wang, H., Ahmed, W., Kumar, A., Byrne, B., Loland, Claus Juul, Guan, L., Liu, X. & Chae, P. S., 2022, In: Chemical Science. 13, p. 5750-5759 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites
Banala, A. K., Zhang, P., Plenge, P., Cyriac, G., Kopajtic, T., Katz, J. L., Loland, Claus Juul & Newman, A. H., 12 Dec 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9709-24 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation
Bae, H. E., Gotfryd, K., Thomas, J., Hussain, H., Ehsan, M., Go, J., Loland, Claus Juul, Byrne, B. & Chae, P. S., 2015, In: ChemBioChem. 16, 10, p. 1454–1459 6 p.Research output: Contribution to journal › Letter › Research › peer-review
ID: 4359
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
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224
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
Research output: Contribution to journal › Journal article › Research › peer-review
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195
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A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
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