Claus Juul Løland
Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
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Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study
Cho, K. H., Husri, M., Amin, A., Gotfryd, K., Lee, H. J., Go, J., Kim, J. W., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 2015, In: The Analyst. 140, 9, p. 3157-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability
Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance
Ghani, L., Kim, S., Ehsan, M., Lan, B., Poulsen, I. H., Dev, C., Katsube, S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X., Im, W. & Chae, P. S., 2023, In: Chemical Science. 14, 45, 11 p., 13014.Research output: Contribution to journal › Journal article › Research › peer-review
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Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy
Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Markham, K., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 Dec 2016, In: Chemistry: A European Journal. 22, 52, p. 18833–18839Research output: Contribution to journal › Journal article › Research › peer-review
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Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, , 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile
Okorom, A. V., Camacho-Hernandez, G. A., Salomon, Kristine Walløe, Lee, K. H., Ku, T. C., Cao, J., Won, S. J., Friedman, J., Lam, J., Paule, J., Rais, R., Klein, B., Xi, Z. X., Shi, L., Loland, Claus Juul & Newman, A. H., 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 709-727 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.
Sørensen, G., Jensen, M., Weikop, Pia, Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neurotransmitter Transporters: Structure, Function, and Drug Binding
Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Neurotransmitter transporters: structure and function
Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability
Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Tripod Amphiphiles for Membrane Protein Analysis
Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation
Cho, K. H., Du, Y., Scull, N. J., Hariharan, P., Gotfryd, K., Loland, Claus Juul, Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2015, In: Chemistry: A European Journal. 21, 28, p. 10008–10013 6 p.Research output: Contribution to journal › Letter › Research › peer-review
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Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors
Cao, J., Slack, R. D., Bakare, O. M., Burzynski, C., Rais, R., Slusher, B. S., Kopajtic, T., Bonifazi, A., Ellenberger, M. P., Yano, H., He, Y., Bi, G., Xi, Z., Loland, Claus Juul & Newman, A. H., 8 Dec 2016, In: Journal of Medicinal Chemistry. 59, 23, p. 10676-10691 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017Research output: Other contribution › Research
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Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization
Bae, H. E., Cecchetti, C., Du, Y., Katsube, S., Mortensen, Jonas Sigurd, Huang, W., Rehan, S., Lee, H. J., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2020, In: Acta Biomaterialia. 112, p. 250-261 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Persistent binding at dopamine transporters determines sustained psychostimulant effects
Niello, M., Sideromenos, S., Gradisch, R., O'Shea, R., Schwazer, J., Maier, J., Kastner, N., Sandtner, W., Jäntsch, K., Lupica, C. R., Hoffman, A. F., Lubec, G., Loland, Claus Juul, Stockner, T., Pollak, D. D., Baumann, M. H. & Sitte, H. H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, 11 p., e2114204120.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster
Pugh, Ciara Frances, DeVree, B. T., Schmidt, S. G. & Loland, Claus Juul, 2022, In: Cells. 11, 23, 15 p., 3811.Research output: Contribution to journal › Journal article › Research › peer-review
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Preface: Special issue on neurotransmitter transporters
Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.Research output: Contribution to journal › Editorial › Research › peer-review
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Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing dopamine transporter structure and function y Zn2+ site engineering
Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97Research output: Contribution to journal › Review › Research › peer-review
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Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS
Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT
Calugareanu, D., Möller, I. R., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.Research output: Contribution to journal › Journal article › Research › peer-review
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R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse
Loland, Claus Juul, Mereu, M., Okunola, O. M., Cao, J., Prisinzano, T. E., Mazier, S., Kopajtic, T., Shi, L., Katz, J. L., Tanda, G. & Newman, A. H., Sep 2012, In: Biological Psychiatry. 72, 5, p. 405-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization
Yoon, S., Bae, H. E., Hariharan, P., Nygaard, Andreas, Lan, B., Woubshete, M., Sadaf, A., Liu, X., Loland, Claus Juul, Byrne, B., Guan, L. & Chae, P. S., 2024, In: Bioconjugate Chemistry. 35, 2, p. 223–231 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Realizing integration in structural biology: The 2022 ISBUC Annual Meeting
Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.
Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability
Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability
Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study
Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity
Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short-Range Distance Measurement by Transition Metal Ion FRET
Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter
Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability
Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846Research output: Contribution to journal › Journal article › Research › peer-review
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Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders
Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B. S., Shi, L., Loland, Claus Juul & Newman, A. H., Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability
Slack, R. D., Ku, T. C., Cao, J., Giancola, J. L. B., Bonifazi, A., Loland, Claus Juul, Gadiano, A., Lam, J., Rais, R., Slusher, B. S., Coggiano, M., Tanda, G. & Newman, A. H., 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2343-2357 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate-Induced Conformational Dynamics of the Dopamine Transporter
Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
ID: 4359
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
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195
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A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Research output: Contribution to journal › Journal article › Research › peer-review
Published