Claus Juul Løland

Claus Juul Løland

Professor

ORCID: 0000-0002-1773-1446

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  1. Published

    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

    Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT

    Topiol, S., Bang-Andersen, B., Sanchez, C., Plenge, P., Loland, Claus Juul, Juhl, K., Larsen, K., Bregnedal, P. & Bøgesø, K. P., 1 Feb 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 3, p. 470-478 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Vitamin E-based glycoside amphiphiles for membrane protein structural studies

    Ehsan, M., Du, Y., Molist, I., Seven, A. B., Hariharan, P., Mortensen, Jonas Sigurd, Ghani, L., Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2018, In: Organic and Biomolecular Chemistry. 16, 14, p. 2489-2498 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM

    Kalenderoglou, I. E., Plenge, P., Yang, D., Salomon, K., Laursen, L., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2022, In: Biophysical Journal. 121, 3, p. 26-26 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  5. Published

    Use of dihydro-isobenzofuran in combination with serotonin reuptake inhibitors for CNS disease e.g. depression, anxiety, bipolar disorder, obsessive compulsory disorder

    Bøgesø, K. P., Juhl, K., Zhong, H. & Loland, Claus Juul, 2013, IPC No. C07D-307/79, Patent No. WO2013110313-A1, Priority date 21 Aug 2013, Priority No. WOEP050952

    Research output: Patent

  6. Published

    Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

    Targowska-Duda, K. M., Budzynska, B., Michalak, A., Wnorowski, A., Loland, Claus Juul, Maj, M., Manetti, D., Romanelli, M. N., Jozwiak, K., Biala, G. & Arias, H. R., 2021, In: European Neuropsychopharmacology. 52, p. 31-47 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

    Ghani, L., Zhang, X., Munk, C. F., Hariharan, P., Lan, B., Yun, H. S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X. & Chae, P. S., 2023, In: Bioconjugate Chemistry. 34, 4, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 2019, In: Organic & Biomolecular Chemistry. 17, 12, p. 3249-3257 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  10. Published

    Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

    Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters

    Loland, Claus Juul, Mar 2015, In: BBA General Subjects. 1850, 3, p. 500-510 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The binding sites for cocaine and dopamine in the dopamine transporter overlap.

    Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The binding sites for benztropines and dopamine in the dopamine transporter overlap

    Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

    Plenge, P., Yang, D., Salomon, K., Laursen, L., Kalenderoglou, I. E., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2021, In: Nature Communications. 12, 1, 12 p., 5063.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation

    Abramyan, A. M., Stolzenberg, S., Li, Z., Loland, Claus Juul, Noe, F. & Shi, L., 2017, In: A C S Chemical Neuroscience. 8, 8, p. 1735-1746 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The Environment Shapes the Inner Vestibule of LeuT

    Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

    Bae, H. E., Mortensen, Jonas Sigurd, Ribeiro, O., Du, Y., Ehsan, M., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Chae, P. S., 4 Oct 2016, In: Chemical communications (Cambridge, England). 52, 81, p. 12104-12107 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

    Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Tandem Facial Amphiphiles for Membrane Protein Stabilization

    Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions

    Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Substrate-induced conformational dynamics of the dopamine transporter

    Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

    Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  27. Published

    Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

    Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

    Slack, R. D., Ku, T. C., Cao, J., Giancola, J. L. B., Bonifazi, A., Loland, Claus Juul, Gadiano, A., Lam, J., Rais, R., Slusher, B. S., Coggiano, M., Tanda, G. & Newman, A. H., 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2343-2357 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

    Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B. S., Shi, L., Loland, Claus Juul & Newman, A. H., Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability

    Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

    Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Short-Range Distance Measurement by Transition Metal Ion FRET

    Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  35. Published

    Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

    Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

    Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

    Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

    Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

    Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability

    Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

    Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Regulation of dopamine transporter trafficking by intracellular amphetamine.

    Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

    Yoon, S., Bae, H. E., Hariharan, P., Nygaard, Andreas, Lan, B., Woubshete, M., Sadaf, A., Liu, X., Loland, Claus Juul, Byrne, B., Guan, L. & Chae, P. S., 2024, In: Bioconjugate Chemistry. 35, 2, p. 223–231 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

    Loland, Claus Juul, Mereu, M., Okunola, O. M., Cao, J., Prisinzano, T. E., Mazier, S., Kopajtic, T., Shi, L., Katz, J. L., Tanda, G. & Newman, A. H., Sep 2012, In: Biological Psychiatry. 72, 5, p. 405-13 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT

    Calugareanu, D., Möller, I. R., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

    Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Probing dopamine transporter structure and function y Zn2+ site engineering

    Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    Probing dopamine transporter structure and function by Zn2+-site engineering

    Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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