Claus Juul Løland
Professor
Neuropharm and Genetics
Blegdamsvej 3
2200 København N.
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target
Loland, Claus Juul, Sanchez, C., Plenge, P., Bøgesø, K. P. & Bang-Andersen, B., 2017, Allosterism in Drug Discovery. Royal Society of Chemistry, p. 360-380 21 p. (RSC Drug Discovery Series; No. 56).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
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R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse
Loland, Claus Juul, Mereu, M., Okunola, O. M., Cao, J., Prisinzano, T. E., Mazier, S., Kopajtic, T., Shi, L., Katz, J. L., Tanda, G. & Newman, A. H., Sep 2012, In: Biological Psychiatry. 72, 5, p. 405-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability
Lee, H. S., Das, M., Mahler, F., Ahmed, W., Wang, H., Mortensen, Jonas Sigurd, Hariharan, P., Ghani, L., Byrne, B., Guan, L., Loland, Claus Juul, Keller, S. & Chae, P. S., 2022, In: Chemistry - An Asian Journal. 17, 24, 9 p., e202200941.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study
Lee, H. J., Ehsan, M., Zhang, X., Katsube, S., Munk, C. F., Wang, H., Ahmed, W., Kumar, A., Byrne, B., Loland, Claus Juul, Guan, L., Liu, X. & Chae, P. S., 2022, In: Chemical Science. 13, p. 5750-5759 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity
Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Realizing integration in structural biology: The 2022 ISBUC Annual Meeting
Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754Research output: Contribution to journal › Journal article › Research › peer-review
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Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An intracellular interaction network regulates conformational transitions in the dopamine transporter.
Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM
Kalenderoglou, I. E., Plenge, P., Yang, D., Salomon, K., Laursen, L., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2022, In: Biophysical Journal. 121, 3, p. 26-26 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The binding sites for benztropines and dopamine in the dopamine transporter overlap
Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Jagalski, V., Barker, R. D., Thygesen, Mikkel Boas, Gotfryd, K., Krüger, M. B., Shi, L., Maric, S., Bovet, N. E., Moulin, M., Haertlein, M., Pomorski, Thomas Guenther, Loland, Claus Juul & Cardenas Gomez, M., 2015, In: Soft Matter. 11, 39, p. 7707-7711 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability
Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
Hussain, H., Du, Y., Scull, N. J., Mortensen, Jonas Sigurd, Tarrasch, J., Bae, H. E., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 17 May 2016, In: Chemistry: A European Journal. 22, 21, p. 7068-7073 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability
Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, , 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
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Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance
Ghani, L., Kim, S., Ehsan, M., Lan, B., Poulsen, I. H., Dev, C., Katsube, S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X., Im, W. & Chae, P. S., 2023, In: Chemical Science. 14, 45, 11 p., 13014.Research output: Contribution to journal › Journal article › Research › peer-review
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Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins
Ghani, L., Zhang, X., Munk, C. F., Hariharan, P., Lan, B., Yun, H. S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X. & Chae, P. S., 2023, In: Bioconjugate Chemistry. 34, 4, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization
Ghani, L., Kim, S., Wang, H., Lee, H. S., Mortensen, Jonas Sigurd, Katsube, S., Du, Y., Sadaf, A., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W., Chae, P. S. & Ahmed, W., 2022, In: Chemistry: A European Journal. 28, 21, 9 p., e202200116.Research output: Contribution to journal › Journal article › Research › peer-review
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1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization
Ghani, L., Munk, C. F., Zhang, X., Katsube, S., Du, Y., Cecchetti, C., Huang, W., Bae, H. E., Saouros, S., Ehsan, M., Guan, L., Liu, X., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2019, In: Journal of the American Chemical Society. 141, 50, p. 19677-19687 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites
Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198Research output: Contribution to journal › Journal article › Research › peer-review
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Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578Research output: Contribution to journal › Journal article › Research › peer-review
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability
Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554Research output: Contribution to journal › Journal article › Research › peer-review
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Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies
Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, Jonas Sigurd, Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 Mar 2016, In: Journal of the American Chemical Society. 138, 11, p. 3789-3796 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study
Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study
Ehsan, M., Wang, H., Katsube, S., Munk, C. F., Du, Y., Youn, T., Yoon, S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2022, In: ChemBioChem. 23, 7, e202200027.Research output: Contribution to journal › Journal article › Research › peer-review
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Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability
Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability
Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability
Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vitamin E-based glycoside amphiphiles for membrane protein structural studies
Ehsan, M., Du, Y., Molist, I., Seven, A. B., Hariharan, P., Mortensen, Jonas Sigurd, Ghani, L., Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2018, In: Organic and Biomolecular Chemistry. 16, 14, p. 2489-2498 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability
Das, M., Du, Y., Mortensen, Jonas Sigurd, Bae, H. E., Byrne, B., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 11 Jul 2018, In: Chemistry - A European Journal. 24, 39, p. 9860-9868 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties
Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, Jonas Sigurd, Patra, D., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Journal of the American Chemical Society. 139, 8, p. 3072-3081Research output: Contribution to journal › Journal article › Research › peer-review
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Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability
Das, M., Du, Y., Mortensen, Jonas Sigurd, Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 2019, In: Organic & Biomolecular Chemistry. 17, 12, p. 3249-3257 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study
Das, M., Mahler, F., Hariharan, P., Wang, H., Du, Y., Mortensen, Jonas Sigurd, Patallo, E. P., Ghani, L., Glück, D., Lee, H. J., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K., Keller, S. & Chae, P. S., 2020, In: Journal of the American Chemical Society. 142, 51, p. 21382–21392 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region
Das, M., Du, Y., Mortensen, Jonas Sigurd, Ribeiro, O., Hariharan, P., Guan, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 2, p. 1169-1177 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4359
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799
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Grafted biomembranes containing membrane proteins – the case of the leucine transporter
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
226
downloads
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
195
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A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Research output: Contribution to journal › Journal article › Research › peer-review
Published