Distribution of histamine H3 binding in forebrain of mouse and guinea pig.

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Standard

Distribution of histamine H3 binding in forebrain of mouse and guinea pig. / Cumming, P; Laliberté, C; Gjedde, A.

In: Brain Research, Vol. 664, No. 1-2, 1994, p. 276-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cumming, P, Laliberté, C & Gjedde, A 1994, 'Distribution of histamine H3 binding in forebrain of mouse and guinea pig.', Brain Research, vol. 664, no. 1-2, pp. 276-9.

APA

Cumming, P., Laliberté, C., & Gjedde, A. (1994). Distribution of histamine H3 binding in forebrain of mouse and guinea pig. Brain Research, 664(1-2), 276-9.

Vancouver

Cumming P, Laliberté C, Gjedde A. Distribution of histamine H3 binding in forebrain of mouse and guinea pig. Brain Research. 1994;664(1-2):276-9.

Author

Cumming, P ; Laliberté, C ; Gjedde, A. / Distribution of histamine H3 binding in forebrain of mouse and guinea pig. In: Brain Research. 1994 ; Vol. 664, No. 1-2. pp. 276-9.

Bibtex

@article{2cc840e0b31511debc73000ea68e967b,
title = "Distribution of histamine H3 binding in forebrain of mouse and guinea pig.",
abstract = "To map the unknown distribution of histamine H3 binding sites, we compared autoradiographs of the binding of the H3 agonist N alpha-[3H]methylhistamine ([3H]NAMH) in the forebrain of mouse and guinea pig. Saturation binding revealed the presence of a single site with apparent affinity of 0.75 nM in the mouse and 1.2 nM in the guinea pig. Binding constants were nearly identical in male and female mice. The rank order of [3H]NAMH binding in mouse brain was striatum > insular cortex > neocortex, as previously observed in the rat. In the guinea pig, the rank order was insular cortex > striatum approximately neocortex. The Bmax of [3H]NAMH in insular cortex of both species was close to 60 fmol/mg. Thus, the guinea pig differs from the rodent in that the highest density of H3 binding was present in cortical rather than subcortical structures.",
author = "P Cumming and C Lalibert{\'e} and A Gjedde",
year = "1994",
language = "English",
volume = "664",
pages = "276--9",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Distribution of histamine H3 binding in forebrain of mouse and guinea pig.

AU - Cumming, P

AU - Laliberté, C

AU - Gjedde, A

PY - 1994

Y1 - 1994

N2 - To map the unknown distribution of histamine H3 binding sites, we compared autoradiographs of the binding of the H3 agonist N alpha-[3H]methylhistamine ([3H]NAMH) in the forebrain of mouse and guinea pig. Saturation binding revealed the presence of a single site with apparent affinity of 0.75 nM in the mouse and 1.2 nM in the guinea pig. Binding constants were nearly identical in male and female mice. The rank order of [3H]NAMH binding in mouse brain was striatum > insular cortex > neocortex, as previously observed in the rat. In the guinea pig, the rank order was insular cortex > striatum approximately neocortex. The Bmax of [3H]NAMH in insular cortex of both species was close to 60 fmol/mg. Thus, the guinea pig differs from the rodent in that the highest density of H3 binding was present in cortical rather than subcortical structures.

AB - To map the unknown distribution of histamine H3 binding sites, we compared autoradiographs of the binding of the H3 agonist N alpha-[3H]methylhistamine ([3H]NAMH) in the forebrain of mouse and guinea pig. Saturation binding revealed the presence of a single site with apparent affinity of 0.75 nM in the mouse and 1.2 nM in the guinea pig. Binding constants were nearly identical in male and female mice. The rank order of [3H]NAMH binding in mouse brain was striatum > insular cortex > neocortex, as previously observed in the rat. In the guinea pig, the rank order was insular cortex > striatum approximately neocortex. The Bmax of [3H]NAMH in insular cortex of both species was close to 60 fmol/mg. Thus, the guinea pig differs from the rodent in that the highest density of H3 binding was present in cortical rather than subcortical structures.

M3 - Journal article

C2 - 7895042

VL - 664

SP - 276

EP - 279

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -

ID: 14945565