Kenneth Lindegaard Madsen

Kenneth Lindegaard Madsen

Associate Professor - Promotion Programme

ORCID: 0000-0001-9274-6691

Publication year:
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1 - 25 out of 51Page size: 25
  1. 2004
  2. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions

    Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2005
  4. Published

    Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

    Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2006
  6. Published

    GABA(A) receptor function is regulated by lipid bilayer elasticity

    Søgaard, R., Werge, T. M., Bertelsen, C., Lundbye, C., Madsen, Kenneth Lindegaard, Nielsen, Claus Henrik & Lundbaek, J. A., 2006, In: Biochemistry. 45, 43, p. 13118-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2008
  8. Published

    Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1

    Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In: European Journal of Neuroscience. 27, 1, p. 66-82 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Membrane localization is critical for activation of the PICK1 BAR domain

    Madsen, Kenneth Lindegaard, Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., Ammendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-43 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2009
  11. Published

    Amphipathic motifs in BAR domains are essential for membrane curvature sensing

    Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In: EMBO Journal. 28, 21, p. 3303-3314 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    How curved membranes recruit amphipathic helices and protein anchoring motifs

    Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system

    Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2010
  15. Published

    BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature

    Madsen, Kenneth Lindegaard, Bhatia, V. K., Gether, Ulrik & Stamou, Dimitrios, 2010, In: FEBS Letters. 584, 9, p. 1848-55 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

    Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2011
  19. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2012
  21. Published

    Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding

    Ammendrup-Johnsen, I., Thorsen, T. S., Gether, Ulrik & Madsen, Kenneth Lindegaard, 17 Jan 2012, In: Biochemistry. 51, 2, p. 586-96 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway

    Madsen, Kenneth Lindegaard, Thorsen, T. S., Rahbek-Clemmensen, T., Eriksen, J. M. & Gether, Ulrik, 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12293-308 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2013
  24. Published

    A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

    Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

    Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1

    Søgaard, R., Borre, L., Braunstein, T. H., Madsen, Kenneth Lindegaard & MacAulay, Nanna, 12 Jul 2013, In: The Journal of Biological Chemistry. 288, 28, p. 20195-207 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

    Rathje, Mette, Fang, H., Bachman, J. L., Anggono, V., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 27 Aug 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14426-31 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

    Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2014
  31. Published

    Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

    qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

    Rathje, Mette, Fang, H., Bachman, J. L., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

    da Silva Pinheiro, P. C., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, Kenneth Lindegaard, Verhage, M., Gether, Ulrik & Sørensen, Jakob Balslev, 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32, p. 10688-700 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2015
  35. Published

    Response to the challenges of Polydisperse SAXS data analysis: two different SAXS studies of PICK1 produce different structural models

    qrc243, qrc243, Arleth, Lise & Madsen, Kenneth Lindegaard, 2015, In: Structure. 23, 11, p. 1969-1970 2 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  36. Published

    Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering

    Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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