Jens D. Mikkelsen

Jens D. Mikkelsen

Professor

ORCID: 0000-0002-0498-6861

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  1. Published

    Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

    Larsen, M. H., Mikkelsen, Jens D., Hay-Schmidt, Anders & Sandi, C., 2010, In: Journal of Psychiatric Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Efferent connections from the lateral hypothalamic region and the lateral preoptic area to the hypothalamic paraventricular nucleus of the rat

    Larsen, P. J., Hay-Schmidt, Anders & Mikkelsen, Jens D., 1994, In: Journal of Comparative Neurology. 342, 2, p. 299-319 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Effect of a postnatal high-fat diet exposure on puberty onset, estrous cycle regularity, and kisspeptin expression in female rats

    Lie, M. E. K., Overgaard, A. & Mikkelsen, Jens D., 2013, In: Reproductive Biology. 13, 4, p. 298-308 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Modulation of anxiety circuits by serotonergic systems

    Lowry, C. A., Johnson, P. L., Hay-Schmidt, Anders, Mikkelsen, Jens D. & Shekhar, A., Dec 2005, In: Stress: The International Journal on the Biology of Stress . 8, 4, p. 233-246 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

    Lyukmanova, E. N., Shulepko, M. A., Kudryavtsev, D., Bychkov, M. L., Kulbatskii, D. S., Kasheverov, I. E., Astapova, M. V., Feofanov, A. V., Thomsen, M. S., Mikkelsen, Jens D., Shenkarev, Z. O., Tsetlin, V. I., Dolgikh, D. A. & Kirpichnikov, M. P., 2016, In: PLOS ONE. 11, 2, p. 1-14 14 p., e0149733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

    Magnussen, J. H., Ettrup, A., Donat, C. K., Peters, D., Pedersen, M. H. F., Knudsen, G. M. & Mikkelsen, Jens D., 5 Sep 2015, In: European Journal of Pharmacology. 762, p. 35-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus)

    Medger, K., Bennett, N. C., Chimimba, C. T., Oosthuizen, M. K., Mikkelsen, Jens D. & Coen, C. W., 2018, In: The Journal of Comparative Neurology. 526, 15, p. 2388-2405

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Microduplication of 15q13.3 and Xq21.31 in a family with tourette syndrome and comorbidities

    Melchior, L., Bertelsen, B., Debes, Nanette M Monique Mol, Groth, C., Skov, L., Mikkelsen, Jens D., Brøndum-Nielsen, K. & Tümer, Asuman Zeynep, 2013, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 162, 8, p. 825-831 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

    Menezes, M. M., Santini, M., Benvega, M. J., Marek, G. J., Merchant, K. M., Mikkelsen, Jens D. & Svensson, K. A., 2013, In: Neuroscience Journal. 2013, 8 p., 736439.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Neuropeptide Y (NPY) and NPY receptors in the rat pineal gland

    Mikkelsen, Jens D., Hauser, Frank & Olcese, J., 1999, In: Advances in Experimental Medicine and Biology. 460, p. 95-107 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors

    Mikkelsen, Jens D., Hay-Schmidt, Anders & Kiss, A., Jun 2004, In: Annals of the New York Academy of Sciences. 1018, p. 65-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The neuroanatomy of the kisspeptin system in the mammalian brain

    Mikkelsen, Jens D. & Simonneaux, V., 2008, In: Peptides. 30, 1, p. 26-33 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Reprogrammering af modne celler til neuroner

    Mikkelsen, Jens D., Rasmussen, M. A., Meyer, M. & Knudsen, G. M., 2012, In: Ugeskrift for Laeger. 174, 12, p. 786

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

    Mikkelsen, Jens D., Kaad, S., trj450, trj450 & Finsen, Bente, 2023, In: Neurobiology of Aging. 129, p. 50-57 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain

    Mikkelsen, Jens D., trj450, trj450, Bascuñana, P., Bankstahl, M., Bankstahl, J. P. & Pazarlar, B. A., 2022, In: Neuroscience. 499, p. 142-151 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Hypocretin (orexin) in the rat pineal gland: A central transmitter with effects on noradrenaline-induced release of melatonin

    Mikkelsen, Jens D., Hauser, Frank, DeLecea, L., Sutcliffe, J. G., Kilduff, T. S., Calgari, C., Pévet, P. & Simonneaux, V., 2001, In: European Journal of Neuroscience. 14, 3, p. 419-425 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Induced resistance in sugar beet against Cercospora beticola: Induction by dichloroisonicotinic acid is independent of chitinase and β-1,3-glucanase transcript accumulation

    Nielsen, K. K., Bojsen, K., Collinge, David B. & Mikkelsen, Jens D., 1 Jan 1994, In: Physiological and Molecular Plant Pathology. 45, 2, p. 89-99 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Amyloid β neurotoxicity in the cholinergic but not in the serotonergic phenotype of RN46A cells

    Olesen, O. F., Dagø, L. & Mikkelsen, Jens D., 15 Jun 1998, In: Molecular Brain Research. 57, 2, p. 266-274 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The Cholinergic but not the Serotonergic Phenotype of Anew Neuronal Cell Line is Sensitive to β-Amyloid-Induced Toxicity

    Olesen, O. F., Fjord-Larsen, L. & Mikkelsen, Jens D., 1998, Progress in Alzheimer’s and Parkinson’s Diseases . p. 495-501 7 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  20. Published

    Isoform-specific binding of human apolipoprotein E to the non-amyloid β component of Alzheimer's disease amyloid

    Olesen, O. F., Mikkelsen, Jens D., Gerdes, C. & Jensen, P. H., Feb 1997, In: Molecular Brain Research. 44, 1, p. 105-112 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats

    Overgaard, A., Axel, A. M., Lie, M. E., Hansen, H. H. & Mikkelsen, Jens D., Apr 2015, In: Endocrine Regulations. 49, 2, p. 51-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice

    Overgaard, A., Tena-Sempere, M., Franceschini, I., Desroziers, E., Simonneaux, V. & Mikkelsen, Jens D., 2013, In: Peptides. 45, p. 85-90 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus

    Overgaard, A., Holst, K., Mandrup, K., Boberg, J., Christiansen, S., Jacobsen, A. P., Hass, U. & Mikkelsen, Jens D., 2013, In: NeuroToxicology. 37, p. 154-162 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Disparate Changes in Kisspeptin and Neurokinin B Expression in the Arcuate Nucleus After Sex Steroid Manipulation Reveal Differential Regulation of the Two KNDy Peptides in Rats

    Overgaard, A., Ruiz-Pino, F., Castellano, J. M., Tena-Sempere, M. & Mikkelsen, Jens D., 2014, In: Endocrinology. 155, 10, p. 3945-3955 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

    Pazarlar, B. A., trj450, trj450, Petukhov, V., Pinborg, Lars Hageman, Khodosevich, Konstantin & Mikkelsen, Jens D., 2022, In: Molecular Brain. 15, 1, 45.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study

    Pazarlar, B. A., Madsen, C. A., Oyar, E. Ö., Eğilmez, C. B. & Mikkelsen, Jens D., 2022, In: Epilepsy Research. 183, 10 p., 106926.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Developmental expression of α-synuclein in rat hippocampus and cerebral cortex

    Petersen, K., Olesen, O. F. & Mikkelsen, Jens D., Jun 1999, In: Neuroscience. 91, 2, p. 651-659 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis: [incl. Author Correction]

    Pfisterer, U., Petukhov, V., Demharter, S., Meichsner, J., Thompson, J. J., Batiuk, M. Y., Martinez, A. A., Vasistha, Navneet A, Thakur, A., Mikkelsen, Jens D., Adorjan, I., Pinborg, Lars Hageman, Pers, Tune H, von Engelhardt, J., Kharchenko, P. V. & Khodosevich, K., 2020, In: Nature Communications. 11, 1, 19 p., 5038.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus)

    Piekarski, D. J., Zhao, S., Jennings, K. J., Iwasa, T., Legan, S. J., Mikkelsen, Jens D., Tsutsui, K. & Kriegsfeld, L. J., 2013, In: Hormones and Behavior. 64, 3, p. 501-510 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

    Raaberg, L., Nexo, E., Mikkelsen, Jens D. & Poulsen, Steen Seier, 1 Jul 1988, In: Histochemistry. 89, 4, p. 351-356 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

    Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, Ida Vang, Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, Jens D., Fisher, P. M. D., Herth, Matthias Manfred, Plavén-Sigray, P., Knudsen, Gitte Moos & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Melatonin controls seasonal breeding by a network of hypothalamic targets

    Revel, F. G., Masson-Pévet, M., Pévet, P., Mikkelsen, Jens D. & Simonneaux, V., 2009, In: Neuroendocrinology. 90, 1, p. 1-14 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

    Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice

    Salaga, M., Blomster, L. V., Piechota-Polańczyk, A., Zielińska, M., Jacenik, D., Cygankiewicz, A. I., Krajewska, W. M., Mikkelsen, Jens D. & Fichna, J., Jan 2016, In: Journal of Pharmacology and Experimental Therapeutics. 356, 1, p. 157-69 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia

    Santini, M. A., Ratner, C. F., Aznar, S., Klein, A. B., Knudsen, Gitte Moos, Mikkelsen, Jens D. & Klein, A. B., May 2013, In: Journal of Neuroscience Research. 91, 5, p. 634-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI

    Santini, M. A., Balu, D. T., Puhl, M. D., Hill-Smith, T. E., Berg, A. R., Lucki, I., Mikkelsen, Jens D. & Coyle, J. T., 1 Feb 2014, In: Behavioural Brain Research. 259, p. 242-246 5 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  37. Published

    Kisspeptin and the seasonal control of reproduction in hamsters

    Simonneaux, V., Ansel, L., Revel, F. G., Klosen, P., Pévet, P. & Mikkelsen, Jens D., 2008, In: Peptides. 30, 1, p. 146-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42

    Søderman, A., Thomsen, M. S., Hansen, H. H., Nielsen, E. Ø., Jensen, M. S., West, M. J. & Mikkelsen, Jens D., 28 Aug 2008, In: Brain Research. 1227, p. 240-7 8 p.

    Research output: Contribution to journal › Journal article › Research

  39. Published

    The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat

    Thomsen, M. S., Mikkelsen, Jens D., Timmermann, D. B., Peters, D. A., Hay-Schmidt, Anders, Martens, H. A., Hansen, H. H. & Thomsen, M. S., 23 Jun 2008, In: Neuroscience. 154, 2, p. 741-53 13 p.

    Research output: Contribution to journal › Journal article › Research

  40. Published

    Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

    Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, Jens D. & Hansen, J. B., 2022, In: Experimental Neurology. 358, 12 p., 114209.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

    Thomsen, M. S., Arvaniti, M., Jensen, M. M., Shulepko, M. A., Dolgikh, D. A., Pinborg, Lars Hageman, Härtig, W., Lyukmanova, E. N. & Mikkelsen, Jens D., Oct 2016, In: Neurobiology of Aging. 46, p. 13-21 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain

    Thomsen, M. S., Hay-Schmidt, Anders, Hansen, H. H. & Mikkelsen, Jens D., 2010, In: Cerebral Cortex. 20, 9, p. 2092-102 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Distinct neural pathways mediate α7 nicotinic acetylcholine receptor-dependent activation of the forebrain

    Thomsen, M. S., Hay-Schmidt, Anders, Hansen, H. H. & Mikkelsen, Jens D., 2010, In: Cerebral Cortex. 20, 9, p. 2092-102

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

    Thomsen, M. S., Weyn, A. & Mikkelsen, Jens D., 2011, In: Bipolar Disorders (English Edition, Online). 13, 7-8, p. 701-7 7 p.

    Research output: Contribution to journal › Journal article › Research

  45. Published

    Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

    Thomsen, M. S. & Mikkelsen, Jens D., Oct 2012, In: Journal of Neurochemistry. 123, 1, p. 73-83 11 p.

    Research output: Contribution to journal › Journal article › Research

  46. Published

    The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

    Thomsen, M. S. & Mikkelsen, Jens D., 15 Oct 2012, In: Journal of Neuroimmunology. 251, 1-2, p. 65-72 8 p.

    Research output: Contribution to journal › Journal article › Research

  47. Published

    Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated

    Thomsen, M. S., Cinar, B., Jensen, M. M., Lyukmanova, E. N., Shulepko, M. A., Tsetlin, V., Klein, A. B. & Mikkelsen, Jens D., 17 Nov 2014, In: Brain Structure and Function (Print Edition). 219, 6, p. 1923-1934 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

    Thomsen, M. S., Zwart, R., Ursu, D., Jensen, M. M., Pinborg, Lars Hageman, Gilmour, G., Wu, J., Sher, E. & Mikkelsen, Jens D., 2015, In: PLOS ONE. 10, 6, p. 1-16 16 p., e0130572.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats

    Thomsen, M. S., El-Sayed, M. & Mikkelsen, Jens D., 2011, In: PLOS ONE. 6, 11, p. e27014

    Research output: Contribution to journal › Journal article › Research

  50. Published

    alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment

    Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P. & Mikkelsen, Jens D., 2009, In: Neuropharmacology. 56, 6-7, p. 1001-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 32177473