Birgitte Rahbek Kornum

Birgitte Rahbek Kornum

Guest Researcher, Associate Professor - Promotion Programme

ORCID: 0000-0002-2515-9451

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  1. Published

    5-HT radioligands for human brain imaging with PET and SPECT

    Paterson, L. M., Kornum, Birgitte Rahbek, Nutt, D. J., Pike, V. W. & Knudsen, Gitte Moos, Jan 2013, In: Medicinal Research Reviews. 33, 1, p. 54-111 58 p.

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    EIF3G is associated with narcolepsy across ethnicities

    Holm, A., Lin, L., Faraco, J., Mostafavi, S., Battle, A., Zhu, X., Levinson, D. F., Han, F., Gammeltoft, S., Jennum, Poul, Mignot, E. & Kornum, Birgitte Rahbek, 2015, In: European Journal of Human Genetics. 23, 11, p. 1573-80 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS

    Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121

    Research output: Patent

  4. Published

    A critical look at the function of the P2Y11 receptor

    Dreisig, K. & Kornum, Birgitte Rahbek, Sep 2016, In: Purinergic Signalling. 12, 3, p. 427-37 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig

    Nielsen, T. R., Kornum, Birgitte Rahbek, Moustgaard, A. C., Gade, A., Lind, N. M. & Knudsen, Gitte Moos, 2008, In: Behavioural Brain Research. p. 93-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A pig model for studies of serotonergic mechanisms in memory disorders

    Kornum, Birgitte Rahbek, 2009, København: Museum Tusculanum. 69 p.

    Research output: Book/Report › Ph.D. thesis › Research

  7. Published

    Absence of autoreactive CD4(+) T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

    Kornum, Birgitte Rahbek, Burgdorf, Kristoffer Sølvsten, Holm, A., Ullum, H., Jennum, Poul & Knudsen, S., 2017, In: Journal of Neuroimmunology. 309, p. 7-11 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain

    Kornum, Birgitte Rahbek, Stott, S. R. W., Mattsson, B., Wisman, L., Ettrup, A., Hermening, S., Knudsen, Gitte Moos & Kirik, D., 1 Mar 2010, In: Experimental Neurology. 222, 1, p. 70-85 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations

    Dommer, M. W., Dreisig, K. & Kornum, Birgitte Rahbek, 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    An approach for serotonin depletion in pigs: effects on serotonin receptor binding

    Ettrup, A., Kornum, Birgitte Rahbek, Weikop, P. & Knudsen, Gitte Moos, 2011, In: Synapse. 65, 2, p. 136-45 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    An optimized method for measuring hypocretin-1 peptide in the mouse brain reveals differential circadian regulation of hypocretin-1 levels rostral and caudal to the hypothalamus

    Justinussen, Jessica, Holm, A. & Kornum, Birgitte Rahbek, 2015, In: Neuroscience. 310, p. 354-361 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Association mellem narkolepsi og H1N1-influenza

    Kornum, Birgitte Rahbek, Knudsen, S., Gammeltoft, S. & Jennum, Poul, 2013, In: Ugeskrift for Laeger. 175, 12, p. 815

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Attenuation and scatter correction in myocardial SPET: improved diagnostic accuracy in patients with suspected coronary artery disease.

    Kjaer, A., Cortsen, A., Kornum, Birgitte Rahbek, Hasseldam, Henrik & Hesse, B., 2002, In: European Journal of Nuclear Medicine and Molecular Imaging. 29, 11, p. 1438-42 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy

    De la Herrán-Arita, A. K., Kornum, Birgitte Rahbek, Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M., Plazzi, G., Crowe, C., Newell, E. W., Davis, M. M., Mellins, E. D. & Mignot, E., 18 Dec 2013, In: Science Translational Medicine. 5, 216, p. 216ra176

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS

    AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  17. Published

    Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes

    Kornum, Birgitte Rahbek, Licht, C. L., Weikop, P., Knudsen, G. M. & Kleijn, S. A., 9 Jan 2006, In: Neuroscience Letters. 392, 1-2, p. 129-34 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy

    Jennum, Poul, Østergaard Pedersen, L., Czarna Bahl, J. M., Modvig, S., Fog, K., Holm, A., Kornum, Birgitte Rahbek & Gammeltoft, S., 1 Jan 2017, In: Sleep. 40, 1, 9 p., zsw006.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length

    Boddum, K., Hansen, M. H., Jennum, Poul & Kornum, Birgitte Rahbek, 2016, In: PloS one. 11, 3, 13 p., e0151288.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset

    Kornum, Birgitte Rahbek, Pizza, F., Knudsen, S., Plazzi, G., Jennum, Poul & Mignot, E., Oct 2015, In: Brain, Behavior, and Immunity. 49, p. 54-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research

    Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 2011, In: Neuroscience & Biobehavioral Reviews. 35, 3, p. 437-51 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Common variants in P2RY11 are associated with narcolepsy

    Kornum, B. R., Kawashima, M., Faraco, J., Lin, L., Rico, T. J., Hesselson, S., Axtell, R. C., Kuipers, H., Weiner, K., Hamacher, A., Kassack, M. U., Han, F., Knudsen, S., Li, J., Dong, X., Winkelmann, J., Plazzi, G., Nevsimalova, S., Hong, S-C., Honda, Y. & 30 others, Honda, M., Högl, B., Ton, T. G. N., Montplaisir, J., Bourgin, P., Kemlink, D., Huang, Y., Warby, S., Einen, M., Eshragh, J. L., Miyagawa, T., Desautels, A., Ruppert, E., Hesla, P. E., Poli, F., Pizza, F., Frauscher, B., Jeong, J., Lee, S., Strohl, K. P., Longstreth, W. T., Kvale, M., Dobrovolna, M., Ohayon, M. M., Nepom, G. T., Wichmann, H., Rouleau, G. A., Gieger, C., Levinson, D. F. & Jennum, Poul, Jan 2011, In: Nature Genetics. 43, 1, p. 66-71 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    DNMT1 regulates expression of MHC class I in post-mitotic neurons

    Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status

    Weiner Lachmi, K., Lin, L., Kornum, Birgitte Rahbek, Rico, T., Lo, B., Aran, A. & Mignot, E., Apr 2012, In: Human Immunology. 73, 4, p. 405-10 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Diagnostic value of actigraphy in hypersomnolence disorders

    Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Does autoreactivity have a role in narcolepsy?

    Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., Nov 2014, In: Lancet Neurology. 13, 11, p. 1072-1073 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice

    Pagh-Berendtsen, Nicolai, Pavlovskyi, Artem, Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep. 47, 4, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency

    Knudsen, S., Biering-Sørensen, B., Kornum, Birgitte Rahbek, Petersen, E., Ibsen, J. D., Gammeltoft, S., Mignot, E. & Jennum, Poul, 2012, In: Neurology. 79, 1, p. 102-3 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Emerging therapeutic targets for narcolepsy

    Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Evaluation of the novel 5-HT4 receptor PET ligand (11C)SB207145 in the Göttingen minnipig

    Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N. M., Marner, L., Andersen, F. & Knudsen, G. M., 2008, In: Comprehensive Medline. 1, p. 186-96 10 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  31. Published

    Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig

    Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N., Marner, Lisbeth, Andersen, F. & Knudsen, Gitte Moos, 1 Jan 2009, In: Journal of Cerebral Blood Flow and Metabolism. 29, 1, p. 186-96 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice

    Pedersen, Mie Gunni Kolmos, Pérez Arribas, Alba, Kornum, Birgitte Rahbek & Justinussen, Jessica, 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!

    Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.

    Research output: Book/Report › Book › Communication

  35. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Genetics of Human Sleep and Sleep Disorders

    Kornum, Birgitte Rahbek, 2017, Handbook of Neurobehavioural Genetics and Phenotyping. Tucci, V. (ed.). 1 ed. New Jersey: Wiley-Blackwell, p. 295-320 26 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  38. Published

    H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings

    Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  39. Published

    HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy

    Ollila, H. M., Ravel, J-M., Han, F., Faraco, J., Lin, L., Zheng, X., Plazzi, G., Dauvilliers, Y., Pizza, F., Hong, S-C., Jennum, P., Knudsen, S., Kornum, B. R., Dong, X. S., Yan, H., Hong, H., Coquillard, C., Mahlios, J., Jolanki, O., Einen, M. & 15 others, Arnulf, I., Lavault, S., Högl, B., Frauscher, B., Crowe, C., Partinen, M., Huang, Y. S., Bourgin, P., Vaarala, O., Désautels, A., Montplaisir, J., Mack, S. J., Mindrinos, M., Fernandez-Vina, M. & Mignot, E., 8 Jan 2015, In: American Journal of Human Genetics. 96, 1, p. 136-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1

    Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Hjernens regulering af søvn

    Gammeltoft, S., Nordvang, A. H. & Kornum, Birgitte Rahbek, 2013, Søvn. Jennum, P. (ed.). 1 ed. København: Munksgaard , p. 39-50 12 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  42. Published

    How hypocretin agonists may improve the quality of wake in narcolepsy

    Justinussen, Jessica, Jensen, Christine Egebjerg & Kornum, Birgitte Rahbek, 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Human P2Y11 expression level affects human P2X7 receptor-mediated cell death

    Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

    Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., Rico, T. J., Lichtner, P., Dauvilliers, Y., Arnulf, I., Lecendreux, M., Javidi, S., Geisler, P., Mayer, G., Pizza, F., Poli, F., Plazzi, G., Overeem, S., Lammers, G. J., Kemlink, D. & 28 others, Sonka, K., Nevsimalova, S., Rouleau, G., Desautels, A., Montplaisir, J., Frauscher, B., Ehrmann, L., Högl, B., Jennum, Poul, Bourgin, P., Peraita-Adrados, R., Iranzo, A., Bassetti, C., Chen, W., Concannon, P., Thompson, S. D., Damotte, V., Fontaine, B., Breban, M., Gieger, C., Klopp, N., Deloukas, P., Wijmenga, C., Hallmayer, J., Onengut-Gumuscu, S., Rich, S. S., Winkelmann, J. & Mignot, E., 2013, In: P L o S Genetics (Online). 9, 2, 7 p., e1003270.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

    Jiang, W., Birtley, J. R., Hung, S. C., Wang, W., Chiou, S. H., Macaubas, C., Kornum, Birgitte Rahbek, Tian, L., Huang, H., Adler, L., Weaver, G., Lu, L., Ilstad-Minnihan, A., Somasundaram, S., Ayyangar, S., Davis, M. M., Stern, L. J. & Mellins, E. D., 2019, In: Nature Communications. 10, 1, 17 p., 5247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells

    Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

    Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes

    Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus

    Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, 31 p.

    Research output: Working paper › Preprint › Research

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