Berg Lab – University of Copenhagen

Forward this page to a friend Resize Print Bookmark and Share

Department of Neuroscience > Research Groups > Berg Lab

Berg Lab

Associate Professor Rune W. BergLab leader: Associate Professor Rune W. Berg
See also: http://www.berg-lab.net 

My focus has been to combine quantitative approaches of mathematics and physics with experiments using electrophysiology, genetics and other biological tools to better understand the nervous system especially the motor system. I intend to consolidate this unique multi-disciplinary lab in order to contribute in understanding motor control in the brain and spinal motor circuits. I hope that our emphasis on strong quantitative approaches outside mainstream neuroscience will significantly move the research field forward. In particular, we believe investigating populations of neurons, as opposed to the single-neuron tradition, is crucial. In turn, this will likely spur therapeutic strategies for individuals with neurological conditions, especially spinal cord injuries.

  • Neuronal Population activity in the spinal cord and brain using large array electrophysiology.
  • Development of novel probe technology
  • Classification of network architecture in the spinal cord motor circuits.
  • Histological clearing techniques for large sample imaging
  • Chronic implantation of electrodes and optical fibers in the central nervous system.

Key publications last 10 years  

  • Jensen, KHR, and Berg RW "Advances and perspectives in tissue clearing using CLARITY", J. Chemical Neuroanatomy, 86: 19-34, 2017
  • Berg, RW, MT Stauning, JB Sorensen, H Jahnsen (2017). "Penetration of action potentials during collision in the median and lateral giant axons of invertebrates'" Physical Review X,april 2017 
  • Jensen, KHR, RW Berg "CLARITY-compatible lipophilic dyes for electrode marking and neuronal tracing" Scientific Reports, 6:32674, 2016
  • Petersen, PC and RW Berg (2016) Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks eLife; 10.7554/eLife.
  • Vestergaard, M and RW Berg "Divisive gain modulation of motoneurons by inhibition optimizes muscular control" J. Neuroscience 35(8):3711-3723, 2015 
  • Petersen, PC, M Vestergaard, KHR Jensen, and RW Berg "Premotor spinal network with balanced excitation and inhibition during motor patterns has high resilience to structural division" J. Neuroscience 34(8): 2774–2784, 2014
  • R. W. Berg, A. Alaburda and J. Hounsgaard (2007) Balanced inhibition and excitation drives spike activity in spinal half-center" Science, vol. 315(5810) 390-393.

Technological achievements:
 Designed the Berg64-probe now sold at Neuronexus http://neuronexus.com/custom-design/dr-rune-berg