Motor-learning based activities may improve functional ability in adults with severe cerebral palsy: A controlled pilot study
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Motor-learning based activities may improve functional ability in adults with severe cerebral palsy : A controlled pilot study. / Hüche Larsen, Helle; Frisk, Rasmus Feld; Willerslev-Olsen, Maria; Nielsen, Jens Bo.
In: NeuroRehabilitation, Vol. 48, No. 3, 2021, p. 273-283.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Motor-learning based activities may improve functional ability in adults with severe cerebral palsy
T2 - A controlled pilot study
AU - Hüche Larsen, Helle
AU - Frisk, Rasmus Feld
AU - Willerslev-Olsen, Maria
AU - Nielsen, Jens Bo
N1 - Publisher Copyright: © 2021-IOS Press. All rights reserved.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Cerebral palsy (CP) is a neurodevelopmental disturbance characterized by impaired control of movement. Function often decreases and 15% of adults are classified as severely affected (Gross Motor Function Classification Scale III-V). Little is known about interventions that aim to improve functional abilities in this population.OBJECTIVE: To evaluate a 12-week intervention based on motor learning principles on functional ability in adults with severe CP.METHODS: 16 adults (36±10 years, GMFCS III-V) were enrolled and divided into an intervention group (Active group) and a standard care group (Control group). Primary outcome measure was Gross Motor Function Measure (GMFM-88). Secondary measures were neurological status. The Active group were measured at baseline, after the intervention and at one-month follow-up. The Control group were measured at baseline and after one month.RESULTS: Analysis showed statistically significant improvement in GMFM-88 for the Active group from baseline to post assessment compared with the Control group (group difference: 5 points, SE 14.5, p = 0.008, CI: 1.2 to 8.7). Improvements were maintained at follow-up. Results from the neurological screening showed no clear tendencies.CONCLUSIONS: The study provides support that activities based on motor learning principles may improve gross motor function in adults with severe CP.
AB - BACKGROUND: Cerebral palsy (CP) is a neurodevelopmental disturbance characterized by impaired control of movement. Function often decreases and 15% of adults are classified as severely affected (Gross Motor Function Classification Scale III-V). Little is known about interventions that aim to improve functional abilities in this population.OBJECTIVE: To evaluate a 12-week intervention based on motor learning principles on functional ability in adults with severe CP.METHODS: 16 adults (36±10 years, GMFCS III-V) were enrolled and divided into an intervention group (Active group) and a standard care group (Control group). Primary outcome measure was Gross Motor Function Measure (GMFM-88). Secondary measures were neurological status. The Active group were measured at baseline, after the intervention and at one-month follow-up. The Control group were measured at baseline and after one month.RESULTS: Analysis showed statistically significant improvement in GMFM-88 for the Active group from baseline to post assessment compared with the Control group (group difference: 5 points, SE 14.5, p = 0.008, CI: 1.2 to 8.7). Improvements were maintained at follow-up. Results from the neurological screening showed no clear tendencies.CONCLUSIONS: The study provides support that activities based on motor learning principles may improve gross motor function in adults with severe CP.
KW - cerebral palsy
KW - motor function
KW - Motor learning
KW - neuroplasticity
KW - neurorehabilitation
KW - rehabilitation
KW - training
U2 - 10.3233/NRE-201581
DO - 10.3233/NRE-201581
M3 - Journal article
C2 - 33523030
AN - SCOPUS:85105467564
VL - 48
SP - 273
EP - 283
JO - NeuroRehabilitation
JF - NeuroRehabilitation
SN - 1053-8135
IS - 3
ER -
ID: 269722293