Publication List – University of Copenhagen

Publication List

Nanna MacAulay


69. Brian Roland Larsen, Anca Stoica, NannaMacAulay (2018) Developmental maturation of activity-induced K+and pH transients and the associated extracellular space dynamics in the rat hippocampus. Journal of Physiology, Epub ahead of print

68. Claudia Brandt, P Seja, Katrin Töllner, Kerstin Römermann, Philip Hampel, M Kalesse, A Kipper, Peter W Feit, Kasper Lykke, Trine L Toft-Bertelsen, P Paavilainen, I Spoljaric, Martin Puskarjov , NannaMacAulay, Kai Kaila, Wolfgang Löscher (2018) Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy. Neuropharmacology 143:186-204

67. Eva Kjer Oernbo, Kasper Lykke, Annette B. Steffensen, Kathrin Töllner, Christina Kruuse, Martin Fredensborg Rath, Wolfgang Löscher & Nanna MacAulay (2018) Cerebral influx of Na+ and Cl- as the osmotherapy-mediated rebound response in rats. Fluids and Barriers in the CNS 15:27

66. Philip Hampel, Kerstin Römermann, Nanna MacAulay, Wolfgang Löscher (2018) Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Scientific Reports 8:9877

65. Annette B. Steffensen, Eva K. Oernbo, Anca Stoica, Niklas J. Gerkau, Dagne Barbuskaite, Katerina Tritsaris, Christine R. Rose & Nanna MacAulay (2018) Cotransporter-mediated water transport underlying cerebrospinal fluid formation. Nature Communications 9:2167

64. Katja Stahl, S. Rahmani, A. Prydz, N. Skauli, Nanna MacAulay, M.N. Mylonakou, R. Torp, Ø. Skare, T. Berg, T.B. Leergaard, R.E. Paulsen, O.P. Ottersen, Mahmood Amiry-Moghaddam (2018) Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One 13:e0194896

63. Trine L. Toft-Bertelsen, Brian Roland Larsen & Nanna MacAulay (2018) Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? Channels 12;100-108

62. Siren Berland, Trine L. Toft-Bertelsen, Ingvild Aukrust, Jan Byska, Marc Vaudel, Laurence A. Bindoff, Nanna MacAulay (shared senior authorship) & Gunnar Houge (2018) A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. Molecular Case Studies 4(1), pii: a002303


61. Brian Skriver Nielsen, Jette Skov Alstrom,Bruce J. Nicholson, Morten Schak Nielsen & Nanna MacAulay (2017) Permeant-specific gating of connexin 30 hemichannels. Journal of Biological Chemistry 292:19999-20009

60. Kasper Lykke, Mette Assentoft, Sofie Hørlyck, Hans Christian C. Helms, Anca Stoica, Trine L. Toft-Bertelsen, Katerina Tritsaris, Frederik Vilhardt, Birger Brodin & Nanna MacAulay (2017) Evaluating the involvement of cerebralmicrovascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter (NKCC1) in electrolyte fluxes in an in vitro BBB model of dehydration. Journal of Cerebral Blood Flow and Metabolism, Epub
ahead of print.

59. Lena Rosenbaek, Federica Rizzo, Qi Wu, Lorena Rojas-Vega, Gerardo Gamba Ayala, Nanna MacAulay, Oliver Staub & Robert A. Fenton (2017) The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation. Scientific
Reports 7(1):12981

58. Anca Stoica, Brian Roland Larsen, Mette Assentoft, Rikke Holm, Leanne M. Holt, Frederik Vilhardt, Bente Vilsen, Karin Lykke-Hartmann, Michelle L. Olsen & Nanna MacAulay (2017) The α2β2 isoform combination dominates the astrocytic Na+ /K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. GLIA 65:1777-1793

57. Brian Roland Larsen & Nanna MacAulay (2017) Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms. GLIA 65:1668-1681

56. Lena L. Rosenbaek. F. Rizzo, Nanna MacAulay, Olivier Staub & Robert A. Fenton (2017) Functional Assessment of Sodium Chloride Co-transporter NCC Mutants in Polarized Mammalian Epithelial Cells. American Journal of Physiology - Renal Physiology 313:F495-F504

55.  Brian s. Nielsen, Daniel B. Hansen, Bruce R. Ransom, Morten S. Nielsen & Nanna MacAulay (2017) Connexin hemichannels in astrocytes: An assessment of controversies regarding their functional characteristics. Neurochemical
Research 42:2537-2550

54.  Trine L. Toft-Bertelsen, David Krízaj & Nanna MacAulay (2017) When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor. Journal of Physiology 595:3287-3302


53. Emma Olesen, Hanne Moeller, Mette Assentoft, Nanna MacAulay & Robert Fenton (2016) The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway. American Journal of Physiology – Renal Physiology 311:935-944

52. Mette Assentoft, Shreyas Kaptan, Hans-Peter Schneider, Joachim W. Deitmer, Bert L. de Groot & Nanna MacAulay (2016) Aquaporin 4 as a NH3 channel. Journal of Biological Chemistry 291:19184-19195

51. P. Wanitchakool, J. Ousingsawat, L. Sirianant, Nanna MacAulay, Rainer Schreiber & Karl Kunzelmann (2016) Cl- channels in apoptosis. European Biophysical Journal 45: 599-610

50. Brian Roland Larsen, Rikke Holm, Bente Vilsen & Nanna MacAulay (2016) Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+ management during neuronal activity. Journal of Physiology 594:6627-6641      

49. Brian Roland Larsen, Anca Stoica & Nanna MacAulay (2016) Managing brain extracellular K+ during neuronal activity: The physiological role of the Na+/K+-ATPase subunit isoforms. Frontiers of Physiology 7(141), fphys.2016.00141

48. Kasper Lykke, Kathrin Töllner, Peter W. Feit, Thomas Erker, Nanna MacAulay & Wolfgang Löscher (2016) The search for NKCC1-selective drugs: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Epilepsy & Behavior 59:42-49

47. Nils Landegren, M. Pourmousa Lindberg, J. Skov, Å. Hallgren, D. Eriksson, Trine Lisberg Toft-Bertelsen, Nanna MacAulay, E. Hagforsen, A. Räisänen-Sokolowski, H. Saha, T. Nilsson, G. Nordmark, S. Ohlsson, J. Gustafsson, E.S. Husebye, E. Larsson, M.S. Anderson, J. Perheentupa, F. Rorsman, Robert A. Fenton & O. Kämpe (2016) Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis. Journal of American Society of Nephrology 27:3220-3228

46. Hanne B. Moeller, J. Slengerik-Hansen, T. Aroankins, Mette Assentoft, Nanna MacAulay, Søren K. Moestrup, V. Bhalla & Fenton RA (2016) Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ. Journal of Biological Chemistry 291:2469-84


45. Andrew Jo, Daniel A. Ryskamp, Tam T.T. Phuong, Alan S. Verkman, Oleg YarishkinNanna MacAulay & David Križaj (2015). TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal Müller glia. Journal of Neuroscience 35:13525-13537

44. Shreyas Kaptan, Mette Assentoft, Hans Peter Schneider, Robert A. Fenton, Joachim Deitmer, Nanna MacAulay & Bert de Groot (2015) Is H95 a pH-dependent gate in aquaporin 4? Structure 23:2309-2318

43. Jette S. Alstrom, Daniel B. Hansen, Morten S. Nielsen & Nanna MacAulay (2015) Isoform-specific phosphorylation-dependent regulation of connexin hemichannels. Journal of Neurophysiology 14:3014-22

42. Annette B. Steffensen, Jeremy Sword, Deborah Croom, Sergei A. Kirov & Nanna MacAulay (2015) Cotransporters as a molecular mechanism underlying spreading depolarization-induced dendritic beading. Journal of Neuroscience 35:12172-12187

41. Kasper Lykke, Mette Assentoft, Robert A. Fenton, Mette M. Rosenkilde & Nanna MacAulay (2015). Vasopressin receptors V1a and V2 are not osmo-sensors. Physiological Reports 3(8), phy2.12519

40. Kasper Lykke, Kathrin Töllner, Kerstin Römermann, Peter W. Feit, Thomas Erker, Nanna MacAulay & Wolfgang Löscher (2015) Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of human NKCC2 variant A. British Journal of Pharmacology, bph.13231

39. Mette Assentoft, Brian Roland Larsen & Nanna MacAulay (2015) Regulation and Function of AQP4 in the Central Nervous System. Neurochemical Research 40:2615-2627

38. Martin N. Andersen, Lasse Skibsbye, C. Tang, F. Petersen, Nanna MacAulay, Hanne B. Rasmussen & Thomas Jespersen (2015) PKC and AMPK regulation of Kv1.5 potassium channels. Channels 9:121-8

37. Jette S. Alstrom, Line W. Stroemlund, Morten S. Nielsen & Nanna MacAulay (2015) Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels. Biochemical Society Transaction 43:519-23

36. Daniel Ryskamp, Andrew Jo, Amber Frye, Felix Vazquez-Chona, Nanna MacAulay, Wallace Thoreson, and David Krizaj (2015) Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia. Journal of Neuroscience 34:15689-15700


35. Brian Roland Larsen & Nanna MacAulay (2014) Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+ clearance in the brain. Channels 8:544-560

34. Mette Assentoft, Brian Roland Larsen, Emma T.B. Olesen, Robert A. Fenton & Nanna MacAulay (2014) AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at C-terminal serine residues. American Journal of Physiology – Cell Physiology 307:957-965

33. Daniel Bloch Hansen, Ye Zu-Cheng, Kirstine Calloe, Thomas H. Braunstein, Johannes P. Hofgaard, Bruce R. Ransom, Morten S. Nielsen & Nanna MacAulay (2014) Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels. Journal of Biological Chemistry 289:26058-26073

32. Daniel Bloch Hansen, Thomas H. Braunstein, Morten S. Nielsen & Nanna MacAulay (2014) Distinct permeation profiles of the connexin 30 and 43 hemichannels. FEBS Letters 588:1446-1457

31. Brian Roland Larsen, Mette Assentoft, Maria L. Cotrina, Susan Z. Hua, Maiken Nedergaard, Kai Kaila, Juha Voipio & Nanna MacAulay (2014) Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+-clearance and volume responses. GLIA 62:608-622


30. Thomas Zeuthen, Magnus Alsterfjord, Eric Beitz & Nanna MacAulay (2013) Osmotic water transport in aquaporins. Evidence for a stochastic mechanism. Journal of Physiology 591:5017-5029

29. Rikke Sogaard, Lars Borre, Thomas H.  Braunstein, Kenneth L. Madsen & Nanna MacAulay (2013) Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1. Journal of Biological Chemistry 288:20195-20207

28. Mette Assentoft, Shreyas Kaptan, Robert A. Fenton, Susan Z. Hua, Bert L. de Groot & Nanna MacAulay (2013) Phosphorylation of rat aquaporin-4 at Ser111 is not required for channel gating. GLIA 61: 1101-1112


27. Lene L. Rosenbaek, Mette Assentoft, Nis B. Pedersen, Nanna MacAulay & Robert A. Fenton (2012) Characterization of a novel phosphorylations site in the sodium chloride transporter, NCC. Journal of Physiology 590:6121-6139

26. Nanna MacAulay & Thomas Zeuthen (2012) Glial K+ clearance and cell swelling: key roles for cotransporters and pumps. Neurochemical Research 37: 2299-2309

25. Thomas Zeuthen & Nanna MacAulay (2012) Transport of water against its concentration gradient: fact or fiction? WIREs Membrane Transport Signaling 1: 373-381 (doi:10.1002/wmts:54)

24. Thomas Zeuthen & Nanna MacAulay (2012) Cotransport of water by the Na+-K+-2Cl- cotransporter expressed in Xenopus oocytes: NKCC1 versus NKCC2. Journal of Physiology 590: 1139-1154

23. Rikke Søgaard, Ivana Novak & Nanna MacAulay (2012) Differential effect of ammonia on three glutamate transporter isoforms expressed in Xenopus oocytes. American Journal of Physiology – Cell Physiology, 302:880-891


22. Robert A. Fenton, Hanne B. Moeller, Marina Zelenina, Marteinn T. Snaebjornsson, Torgeir Holen & Nanna MacAulay (2010) Differential water permeability and regulation of three AQP4 isoforms. Cellular and Molecular Life Sciences. 67:829-840

21. Nanna MacAulay & Thomas Zeuthen (2010) Water transport between CNS compartments: contribution of aquaporins versus co-transporters. Neuroscience 168:941-956


20. Hanne B. Moeller, Robert A. Fenton, Thomas Zeuthen & Nanna MacAulay (2009) Vasopressin-dependent short-term regulation of AQP4 expressed in Xenopus oocytes. Neuroscience 164:1674-1684

19. Nanna MacAulay, Steffen Hamann & Thomas Zeuthen (2009) Chloride transporters as water pumps: Elements in a new model of epithelial water transport. In: Physiology and pathology of chloride transporters and channels in the nervous system. Eds FJ Alvarez-Leefmans & E Delpire. Academic Press, Elsevier pp 547-568

18. Rikke Soe, Nanna MacAulay & Dan Klaerke (2009) Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume. Neurosci. Lett. 457, 80-84

17. Anne-Kristine Meinild, Don D. Loo, Søren Skovstrup, Ulrik Gether & Nanna MacAulay (2009) Elucidating conformational changes in the gamma-aminobutyric acid (GABA)-transporter-1. J. Biol. Chem. 284:16226-15235

16. Rikke Søgaard, Magnus Alsterfjord, Nanna MacAulay & Thomas Zeuthen (2009) Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH. Pflugers Arch., 458: 733-743

15. Hanne B Moeller, Nanna MacAulay (shared first author), Mark A Knepper & Robert A Fenton (2009) Role of multiple phosphorylation sites in the carboxyl-terminal tail of aquaporin-2 for water transport: Evidence against channel gating. Am. J. Physiol. Renal Physiol.296, F649-657


14. Thomas Zeuthen, Emil Zeuthen & Nanna MacAulay (2007) Water transport by GLUT2 expressed in Xenopus laevis oocytes. J. Physiol. 579, 345-361


13. Aidas Alaburda, Raul Russo, Nanna MacAulay & Jørn Hounsgaard (2005) Periodic High and Low Conductance States in Spinal Motoneurons and Interneurons during Scratch-like Network Activity in Adult Turtles. J. Neuroscience 25, 6316-21


12. Nanna MacAulay, Steffen Hamann & Thomas Zeuthen (2004) Water Transport in the Brain: Role of Cotransporters. Neuroscience 129, 1031-1044


11. Nanna MacAulay, Anne-Kristine Meinild, Thomas Zeuthen & Ulrik Gether (2003) Residues in the Extracellular Loop 4 are Critical for Maintaining the Conformational Equilibrium of the g-Aminobutyric Acid (GABA) Transporter-1. J. Biol. Chem 278, 28771-28777

10. Morten Grunnet, Thomas Jespersen, Nanna MacAulay, Nanna K. Jørgensen, Nicole Schmitt, Olaf Pongs, Søren-Peter Olesen & Dan Klærke (2003) KCNQ1 Channels Sense Small Changes in Cell Volume. J. Physiol. 549, 419-427


9. Nanna MacAulay, Thomas Zeuthen & Ulrik Gether (2002) Conformational Basis for the Li+-Induced Leak Current in the rat g-Aminobutyric Acid (GABA) Transporter-1. J. Physiol. 544, 447-458

8. Nanna MacAulay, Ulrik Gether, Dan Klærke & Thomas Zeuthen (2002) Passive Water and Urea Permeability of a Human Na+/Glutamate Cotransporter expressed in Xenopus oocytes. J. Physiol. 542, 817-828

7. Morten Grunnet, Nanna MacAulay, Nanna K. Jørgensen, Bo S. Jensen, Søren-Peter Olesen & Dan Klærke (2002) Regulation of Cloned Ca2+-activated K+ Channels by Cell Volume Changes. Pflugers Arch. 444, 167-177

6. Thomas Zeuthen & Nanna MacAulay (2002) Passive Water Transport in Biological Pores. In International Review of Cytology, vol 215, eds T. Zeuthen & W.D. Stein., pp 259-284. Academic Press, San Diego.

5. Thomas Zeuthen & Nanna MacAulay (2002) Cotransporters as Molecular Water Pumps. In International Review of Cytology, vol 215, eds T. Zeuthen & W.D. Stein., pp 203-230. Academic Press, San Diego.


4. Nanna MacAulay, Annie Bendahan, Claus Juul Loland, Thomas Zeuthen, Baruch I.Kanner  & Ulrik Gether (2001) Engineered Zn2+ Switches in the GABA Transporter-1: Differential Effects on GABA Uptake and Currents. J. Biol. Chem. 276, 40476-40485

3. Nanna MacAulay, Ulrik Gether, Dan Klærke & Thomas Zeuthen (2001) Water Transport by the Na+-coupled Glutamate Cotransporter Expressed in Xenopus Oocytes.  J.Physiol. 530, 367-378


2. Rhoda Blostein, Stewart E. Daly, Nanna Boxenbaum, Lois K. Lane, José M. Arguello, Jerry B. Lingrel, Steve J. D. Karlish & Michael J. Caplan (1998) Conformational Alterations Resulting from Mutations in Cytoplasmic Domains of the Alpha Subunit of the Na,K-ATPase. Acta Physiol. Scand. (Suppl.) 643, 275-281

1. Nanna Boxenbaum, Stewart E. Daly, Zahid Z. Javaid, Lois K. Lane & Rhoda Blostein (1998) Changes in Steady-state Conformational Equilibrium Resulting from Cytoplasmic Mutations of the Na,K-ATPase α-Subunit. J. Biol. Chem. 273, 23086-23092