Lab members – University of Copenhagen

Lab members

Martin Lauritzen, MD

Professor and group leader


I am interested in the characterization of disease processes, in particular consequences of aging and acute central nervous system disorders and the development of new treatment strategies. This is reflected in the research program of our group that carries out research on glial and neuronal control of brain blood flow and oxygen metabolism in health and disease. We have strong research lines in pathological brain waves and stroke (cortical spreading depression and calcium waves), aging and Ca2+ homeostasis. New research lines include studies of capillary function, brain pericytes and the blood-brain barrier. Methods include two-photon laser scanning microscopy of spontaneous and evoked brain cell activity by use of Ca2+ fluorophores, studies of single blood vessels, classic electrophysiology, tissue oxygen measurements, and laser-light based techniques for brain blood flow recordings, all in normal or transgenic mice in vivo.

Phone: +4524841840
Email: mlauritz@sund.ku.dk

Henriette Lajgaard Christensen, PhD

Center coordinator

I have a Master's degree in molecular medicine and a PhD degree in health sciences from Aarhus University. I joined the Lauritzen lab in January 2018 as center coordinator for the Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery (RIBBDD).


Email: henriettelaj@sund.ku.dk

Phone: +45 26221244

Changsi Cai, PhD

PostDoc

I’m interested in the mechanism of regulation of blood flow and metabolism in both health and disease. My current focus is the roles of pericytes in regulation of capillary blood flow. In my study, two-photon microscopy, electrophysiology are used in the in vivo mouse model. I can also make MATLAB programs to analyze data.

Email: ccai@sund.ku.dk

Micael Lønstrup

Veterinary technician

My specialty is microsurgery in rodents (mainly mice) in research models/application, training in microsurgery, the use of anesthesia and analgesia and pre-, peri- and post-operative care of rodents. I mainly prepare mice but also rats for in vivo electrophysiology and two-photon experiments. Over the years I have been working in whisker barrel cortex and cerebellum in different studies, with different stimulation approaches including whisker path, transcallosal and inferior olive stimulations. Conducted several experiments for delivering data to projects in the group and with collaborators from other universities. I run our own small-animal housing unit within our lab, which reduces animal stress and allows for better monitoring and post-operative care. I'm also assisting in the preparation of live tissue preparations for some institute teaching courses.  I have been in Lauritzen lab since 2008 and have been in charge of purchases, payment, and logistics and participated in planning the construction and moving of the whole lab and offices to new facilities at Panum in 2014 as well as our move to the Maersk tower in the spring of 2017.

Email: micl@sund.ku.dk
Phone: +45 24661413

Krzysztof Kucharz, MSc, PhD

Assistant professor

I obtained BSc and MSc degrees in biophysics at Department of Molecular Biology, Krakow, Poland. Subsequently I worked at Uppsala University in collaboration with industry to develop ultra-sensitive protein assays for clinical applications. I received my PhD degree in Neuroscience at Lund University, Faculty of Medicine, Sweden, where I investigated the structural dynamics of cellular organelle in living neurons using various fluorescence imaging techniques. I joined Martin Lauritzen’s lab at University of Copenhagen as a post-doc, with main focus on characterizing the mechanism and relevance of neuronal endoplasmic reticulum (ER) fission-fusion, a phenomenon I discovered during my doctoral studies. In my work I primarily utilize two-photon in vivo microscopy with simultaneous electrophysiological assessment to decipher the effects of ER fission-fusion on neuronal function in physiology and acute brain disorders. In addition, I investigate the mechanisms regulating blood-brain barrier permeability for development of new methods for enhanced drug delivery in vivo.

Email: kucharz@sund.ku.dk
Phone: +46 735 747 060

Reena Murmu Nielsen, PhD

PostDoc

My research interest lies in investigating neuronal and non-neuronal signalling (astrocytic and microglial) under normal as well as pathological conditions using state-of-the-art in vivo two-photon imaging. After obtaining a PhD degree from university of Magdeburg (Germany), I conducted my post-doctoral research in reputed international institutes, where I gained expertise in in vivo two-photon imaging on pre-clinical models of neurodegenerative disorders such as Huntington's and Parkinson's disease. Currently, I am investigating calcium signalling in astrocytes using two-photon imaging and electrophysiology in an animal model of Stroke. The goal of this project is to investigate whether aberrant calcium signalling in astrocytes contributes to the progression of pathology in stroke.

Email: rmurmu@sund.ku.dk
Phone: +45 53770067

Jonas Fordsmann, MD

PostDoc

I graduated as an MD from University of Copenhagen. I have previously worked with neurovascular coupling during cortical spreading depression and stroke. Now I focus on astrocytic calcium activity after acute stroke and in aging.

Email: jonosfo@sund.ku.dk
Phone: +45 27 34 64 07

Kirsten Thomsen, MD, PhD

Senior researcher

In my research I focus on bioenergetics, brain aging, mitochondrial dynamics, neurovascular coupling, GABA, and neuronal inhibition.


Email: 
kthomsen@sund.ku.dk

Matilda Dahlqvist, MSc

PhD student

I have a MSc degree in engineering nanoscience from Lund University. My work revolves around specific neurons' energy metabolism and how they contribute to the neurovascular coupling during aging.


Email: 
mdahlqvist@sund.ku.dk

Nikolay Kutuzov

PhD student


I work with two-photon and confocal microscopy, Raman spectroscopy, the blood-brain barrier, and machine learning.


Email: 
nkutuzov@sund.ku.dk

Phone: +45 53800879

Barbara Lykke Lind, PhD

Assistant professor

I have an MSc degree in human biology from University of Copenhagen and obtained my PhD degree in Martin Lauritzens group. Works with Ca2+ imaging primarily in cortical astrocytes during somatosensory stimulation. 

Email: barbarall@sund.ku.dk
Phone:+45 61777970

Mette Mathiesen Janiurek, MSc

PhD student

In my research I focus on the blood-brain barrier; mainly barrier integrity after pharmacological interventions and alteration of natural signaling pathways. My experiments are performed in vivo using two-photon imaging. 


E-mail: 
cmmathiesen@sund.ku.dk

Stefan Andreas Zambach, MD

PhD student

I am interested in pericyte constriction and the blood-brain barrier under pathological conditions. I work with in vivo experiments and two-photon microscopy.


Email: zambach@sund.ku.dk

Søren Grubb, PhD

PostDoc

In my current research I focus on the role of pericytes in the blood-brain barrier, with special regard to the basal lamina. I have a background in biology, and I have specialized in electrophysiology – such as measuring ion currents (patch clamp) and action potentials (sharp electrode measurements) as well as calcium imaging of isolated cells and intact tissue.


Email: 
sgrubb@sund.ku.dk

Phone: +45 27290007

Bjørn Olav Hald, PhD

PostDoc

I am interested in integrative physiology and have worked primarily with so-called conducted vasomotor responses, which is the integrative mechanism that coordinates vessel tone of arteries and arterioles in microvascular networks. I use both theoretical and experimental techniques, i.e. I develop computational models of biological systems as well as using standard vascular techniques in the lab. I joined the Lauritzen lab in 2017 and will use two-photon microscopy and functional activation of cortex to investigate the interplay between local neurovascular coupling and global blood flow regulation in the brain.


Email: 
bohald@sund.ku.dk

Phone: +45 23900399

Aske Krogsgaard, MSc

PhD student


I hold a Master's degree in physics from Aarhus University. I am interested in the crosstalk between astrocytes and pericytes in relation to functional hyperaemia as well as their involvement in Alzheimer's disease. 


Email: agkjensen@sund.ku.dk

Alexey Brazhe, PhD

Research associate

I graduated from Moscow State University (MSU) and received a PhD degree in biophysics from the same university in 2006. Since then, I worked as post-doc at the Technical University of Denmark and University of Copenhagen. Now I am a senior researcher at MSU. My main research interests are self-organization, novel methods of data analysis, including dimension reduction and multiscale analyses, primarily with application to understanding neuronal and astrocyte dynamics.

Jasmin Pernille Hjerresen

Laboratory assistant

I study molecular biomedicine at University of Copenhagen. I have a big interest in neuroscience, and I joined the Lauritzen lab in June 2018 where I work as a laboratory assistant. Here I take care of genotyping, preparation of buffers etc., and I handle the daily maintenance in the lab.


Email: jhjerre@sund.ku.dk