Claus Juul Løland

Claus Juul Løland

Professor


  1. 2024
  2. Published

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter: sodium symporter LeuT

    Schmidt, Solveig Gaarde, Nygaard, Andreas, Mindell, J. A. & Loland, Claus Juul, 2024, In: eLife. 12, 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

    Okorom, A. V., Camacho-Hernandez, G. A., Salomon, Kristine Walløe, Lee, K. H., Ku, T. C., Cao, J., Won, S. J., Friedman, J., Lam, J., Paule, J., Rais, R., Klein, B., Xi, Z. X., Shi, L., Loland, Claus Juul & Newman, A. H., 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 709-727 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

    Yoon, S., Bae, H. E., Hariharan, P., Nygaard, Andreas, Lan, B., Woubshete, M., Sadaf, A., Liu, X., Loland, Claus Juul, Byrne, B., Guan, L. & Chae, P. S., 2024, In: Bioconjugate Chemistry. 35, 2, p. 223–231 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

    Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journalEditorialpeer-review

  7. 2023
  8. Published

    Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

    Salomon, K., Abramyan, A. M., Plenge, P., Wang, L., Bundgaard, C., Bang-Andersen, B., Loland, Claus Juul & Shi, L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 41, 10 p., e2304089120.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance

    Ghani, L., Kim, S., Ehsan, M., Lan, B., Poulsen, I. H., Dev, C., Katsube, S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X., Im, W. & Chae, P. S., 2023, In: Chemical Science. 14, 45, 11 p., 13014.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Persistent binding at dopamine transporters determines sustained psychostimulant effects

    Niello, M., Sideromenos, S., Gradisch, R., O'Shea, R., Schwazer, J., Maier, J., Kastner, N., Sandtner, W., Jäntsch, K., Lupica, C. R., Hoffman, A. F., Lubec, G., Loland, Claus Juul, Stockner, T., Pollak, D. D., Baumann, M. H. & Sitte, H. H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, 11 p., e2114204120.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published
  12. Published

    Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

    Ghani, L., Zhang, X., Munk, C. F., Hariharan, P., Lan, B., Yun, H. S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X. & Chae, P. S., 2023, In: Bioconjugate Chemistry. 34, 4, 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2022
  14. Published

    3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability

    Lee, H. S., Das, M., Mahler, F., Ahmed, W., Wang, H., Mortensen, Jonas Sigurd, Hariharan, P., Ghani, L., Byrne, B., Guan, L., Loland, Claus Juul, Keller, S. & Chae, P. S., 2022, In: Chemistry - An Asian Journal. 17, 24, 9 p., e202200941.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

    Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, In: Plant Journal. 111, 4, p. 936-953 15866.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study

    Lee, H. J., Ehsan, M., Zhang, X., Katsube, S., Munk, C. F., Wang, H., Ahmed, W., Kumar, A., Byrne, B., Loland, Claus Juul, Guan, L., Liu, X. & Chae, P. S., 2022, In: Chemical Science. 13, p. 5750-5759 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, Solveig Gaarde, Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization

    Ghani, L., Kim, S., Wang, H., Lee, H. S., Mortensen, Jonas Sigurd, Katsube, S., Du, Y., Sadaf, A., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W., Chae, P. S. & Ahmed, W., 2022, In: Chemistry: A European Journal. 28, 21, 9 p., e202200116.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study

    Ehsan, M., Wang, H., Katsube, S., Munk, C. F., Du, Y., Youn, T., Yoon, S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2022, In: ChemBioChem. 23, 7, e202200027.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

    Pugh, Ciara Frances, DeVree, B. T., Schmidt, Solveig Gaarde & Loland, Claus Juul, 2022, In: Cells. 11, 23, 15 p., 3811.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT

    Calugareanu, D., Möller, I. R., Schmidt, Solveig Gaarde, Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, Solveig Gaarde, Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM

    Kalenderoglou, I. E., Plenge, P., Yang, D., Salomon, K., Laursen, L., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2022, In: Biophysical Journal. 121, 3, p. 26-26 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  24. 2021
  25. Published

    Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

    Sadaf, A., Kim, S., Bae, H. E., Wang, H., Nygaard, Andreas, Uegaki, Y., Du, Y., Munk, C. F., Katsube, S., Lee, H. S., Bae, J., Choi, C. W., Choi, H., Byrne, B., Gellman, S. H., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W. & Chae, P. S., 2021, In: Acta Biomaterialia. 128, p. 393-407 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability

    Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

    Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

    Plenge, P., Yang, D., Salomon, K., Laursen, L., Kalenderoglou, I. E., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2021, In: Nature Communications. 12, 1, 12 p., 5063.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

    Targowska-Duda, K. M., Budzynska, B., Michalak, A., Wnorowski, A., Loland, Claus Juul, Maj, M., Manetti, D., Romanelli, M. N., Jozwiak, K., Biala, G. & Arias, H. R., 2021, In: European Neuropsychopharmacology. 52, p. 31-47 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. 2020
  31. Published

    Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

    Niello, M., Gradisch, R., Loland, Claus Juul, Stockner, T. & Sitte, H. H., 2020, In: Trends in Pharmacological Sciences. 41, 7, p. 446-463 18 p.

    Research output: Contribution to journalReviewpeer-review

  32. Published

    Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

    Das, M., Mahler, F., Hariharan, P., Wang, H., Du, Y., Mortensen, Jonas Sigurd, Patallo, E. P., Ghani, L., Glück, D., Lee, H. J., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K., Keller, S. & Chae, P. S., 2020, In: Journal of the American Chemical Society. 142, 51, p. 21382–21392 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

    Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization

    Bae, H. E., Cecchetti, C., Du, Y., Katsube, S., Mortensen, Jonas Sigurd, Huang, W., Rehan, S., Lee, H. J., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2020, In: Acta Biomaterialia. 112, p. 250-261 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

    Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, Solveig Gaarde, Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Short-Range Distance Measurement by Transition Metal Ion FRET

    Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  37. Published

    Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

    Slack, R. D., Ku, T. C., Cao, J., Giancola, J. L. B., Bonifazi, A., Loland, Claus Juul, Gadiano, A., Lam, J., Rais, R., Slusher, B. S., Coggiano, M., Tanda, G. & Newman, A. H., 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2343-2357 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

    Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.

    Research output: Contribution to journalJournal articlepeer-review

  40. 2019
  41. Published

    Conformational dynamics of the human serotonin transporter during substrate and drug binding

    Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization

    Ghani, L., Munk, C. F., Zhang, X., Katsube, S., Du, Y., Cecchetti, C., Huang, W., Bae, H. E., Saouros, S., Ehsan, M., Guan, L., Liu, X., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2019, In: Journal of the American Chemical Society. 141, 50, p. 19677-19687 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

    Bae, H. E., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Kumar, K. K., Ha, B., Das, M., Lee, H. S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemical Science. 10, 4, p. 1107-1116

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability

    Sadaf, A., Ramos, M., Mortensen, Jonas Sigurd, Du, Y., Bae, H. E., Munk, C. F., Hariharan, P., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 2019, In: ACS chemical biology. 14, 8, p. 1717-1726 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

    Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Preface: Special issue on neurotransmitter transporters

    Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.

    Research output: Contribution to journalEditorialpeer-review

  47. Published

    Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

    Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

    Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journalConference abstract in journalpeer-review

  50. Published

    Substrate-induced conformational dynamics of the dopamine transporter

    Nielsen, A. K., Möller, I. R., Wang, Yong, Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 2019, In: Organic & Biomolecular Chemistry. 17, 12, p. 3249-3257 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. 2018
  53. Published

    An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Bae, H. E., Byrne, B., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 11 Jul 2018, In: Chemistry - A European Journal. 24, 39, p. 9860-9868 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

    Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

    Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability

    Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Vitamin E-based glycoside amphiphiles for membrane protein structural studies

    Ehsan, M., Du, Y., Molist, I., Seven, A. B., Hariharan, P., Mortensen, Jonas Sigurd, Ghani, L., Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2018, In: Organic and Biomolecular Chemistry. 16, 14, p. 2489-2498 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. 2017
  61. Published

    Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders

    Zou, M. F., Cao, J., Abramyan, A. M., Kopajtic, T., Zanettini, C., Guthrie, D. A., Rais, R., Slusher, B. S., Shi, L., Loland, Claus Juul & Newman, A. H., Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10172-10187 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

    Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contributionResearch

  64. Published

    X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT

    Topiol, S., Bang-Andersen, B., Sanchez, C., Plenge, P., Loland, Claus Juul, Juhl, K., Larsen, K., Bregnedal, P. & Bøgesø, K. P., 1 Feb 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 3, p. 470-478 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Allosteric Binding in the Serotonin Transporter - Pharmacology, Structure, Function and Potential Use as a Novel Drug Target

    Loland, Claus Juul, Sanchez, C., Plenge, P., Bøgesø, K. P. & Bang-Andersen, B., 2017, Allosterism in Drug Discovery. Royal Society of Chemistry, p. 360-380 21 p. (RSC Drug Discovery Series; No. 56).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  66. Published

    Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Ribeiro, O., Hariharan, P., Guan, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 2, p. 1169-1177 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties

    Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, Jonas Sigurd, Patra, D., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Journal of the American Chemical Society. 139, 8, p. 3072-3081

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study

    Sadaf, A., Du, Y., Santillan, C., Mortensen, Jonas Sigurd, Molist, I., Seven, A. B., Hariharan, P., Skiniotis, G., Loland, Claus Juul, Kobilka, B. K., Guan, L., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 8, 12, p. 8315-8324 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    Erlendsson, Simon, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Neurotransmitter Transporters: Structure, Function, and Drug Binding

    Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  71. Published

    Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability

    Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

    Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation

    Abramyan, A. M., Stolzenberg, S., Li, Z., Loland, Claus Juul, Noe, F. & Shi, L., 2017, In: A C S Chemical Neuroscience. 8, 8, p. 1735-1746 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. 2016
  75. Published

    Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy

    Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Markham, K., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 Dec 2016, In: Chemistry: A European Journal. 22, 52, p. 18833–18839

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length

    Cho, K. H., Hariharan, P., Mortensen, Jonas Sigurd, Du, Y., Nielsen, A. K., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 14 Dec 2016, In: ChemBioChem. 17, 24, p. 2334–2339

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors

    Cao, J., Slack, R. D., Bakare, O. M., Burzynski, C., Rais, R., Slusher, B. S., Kopajtic, T., Bonifazi, A., Ellenberger, M. P., Yano, H., He, Y., Bi, G., Xi, Z., Loland, Claus Juul & Newman, A. H., 8 Dec 2016, In: Journal of Medicinal Chemistry. 59, 23, p. 10676-10691 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    The Environment Shapes the Inner Vestibule of LeuT

    Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

    Bae, H. E., Mortensen, Jonas Sigurd, Ribeiro, O., Du, Y., Ehsan, M., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Chae, P. S., 4 Oct 2016, In: Chemical communications (Cambridge, England). 52, 81, p. 12104-12107 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

    Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, Solveig Gaarde, Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)

    Khelashvili, G., Schmidt, Solveig Gaarde, Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation

    Hussain, H., Du, Y., Scull, N. J., Mortensen, Jonas Sigurd, Tarrasch, J., Bae, H. E., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 17 May 2016, In: Chemistry: A European Journal. 22, 21, p. 7068-7073 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

    Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, Jonas Sigurd, Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 Mar 2016, In: Journal of the American Chemical Society. 138, 11, p. 3789-3796 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study

    Sadaf, A., Mortensen, Jonas Sigurd, Capaldi, S., Tikhonova, E., Hariharan, P., de Castro Ribeiro, O., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1933-1939 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. Published

    Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

    Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. 2015
  87. Published

    Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

    Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters

    Loland, Claus Juul, Mar 2015, In: BBA General Subjects. 1850, 3, p. 500-510 11 p.

    Research output: Contribution to journalReviewpeer-review

  89. Published

    Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation

    Bae, H. E., Gotfryd, K., Thomas, J., Hussain, H., Ehsan, M., Go, J., Loland, Claus Juul, Byrne, B. & Chae, P. S., 2015, In: ChemBioChem. 16, 10, p. 1454–1459 6 p.

    Research output: Contribution to journalLetterpeer-review

  90. Published

    Grafted biomembranes containing membrane proteins – the case of the leucine transporter

    Jagalski, V., Barker, R. D., Thygesen, Mikkel Boas, Gotfryd, K., Krüger, M. B., Shi, L., Maric, S., Bovet, N. E., Moulin, M., Haertlein, M., Pomorski, Thomas Guenther, Loland, Claus Juul & Cardenas Gomez, M., 2015, In: Soft Matter. 11, 39, p. 7707-7711 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study

    Cho, K. H., Husri, M., Amin, A., Gotfryd, K., Lee, H. J., Go, J., Kim, J. W., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 2015, In: The Analyst. 140, 9, p. 3157-63 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

    Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

    Cho, K. H., Du, Y., Scull, N. J., Hariharan, P., Gotfryd, K., Loland, Claus Juul, Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2015, In: Chemistry: A European Journal. 21, 28, p. 10008–10013 6 p.

    Research output: Contribution to journalLetterpeer-review

  94. 2014
  95. Published

    Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

    Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, Weinstein, H., Galli, A., Hjermind, L. E., Møller, L. B. & Gether, Ulrik, 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    A Conserved Salt Bridge between Transmembrane Segment 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter

    Pedersen, A. V., Andreassen, T. F. & Loland, Claus Juul, 2014, In: Journal of Biological Chemistry. 289, 50, p. 35003-350014 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

    Okunola-Bakara, O., Cao, J., Kopajtic, T., Katz, J. L., Loland, Claus Juul, Shi, L. & Newman, A. H., 2014, In: Journal of Medicinal Chemistry. 57, 3, p. 1000-1013 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. 2013
  99. Published

    Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites

    Banala, A. K., Zhang, P., Plenge, P., Cyriac, G., Kopajtic, T., Katz, J. L., Loland, Claus Juul & Newman, A. H., 12 Dec 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9709-24 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  100. Published

    Novel Tripod Amphiphiles for Membrane Protein Analysis

    Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    Correction to "tandem facial amphiphiles for membrane protein stabilization"

    Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 28 Aug 2013, In: Journal of the American Chemical Society. 135, 34, p. 12922 1 p.

    Research output: Contribution to journalJournal article

  102. Published

    Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

    Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

    Simmons, K. J., Gotfryd, K., Billesbølle, C. B., Loland, Claus Juul, Gether, Ulrik, Fishwick, C. W. G. & Johnson, A. P., Mar 2013, In: Molecular Membrane Biology. 30, 2, p. 184-94 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Published

    A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter

    Zhang, P., Jørgensen, T. N., Loland, Claus Juul & Newman, A. H., 1 Jan 2013, In: Bioorg. Med. Chem. Lett.. 23, 1, p. 323-326 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  105. Published

    Use of dihydro-isobenzofuran in combination with serotonin reuptake inhibitors for CNS disease e.g. depression, anxiety, bipolar disorder, obsessive compulsory disorder

    Bøgesø, K. P., Juhl, K., Zhong, H. & Loland, Claus Juul, 2013, IPC No. C07D-307/79, Patent No. WO2013110313-A1, Priority date 21 Aug 2013, Priority No. WOEP050952

    Research output: Patent

  106. 2012
  107. Published

    Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

    Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  108. Published

    R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

    Loland, Claus Juul, Mereu, M., Okunola, O. M., Cao, J., Prisinzano, T. E., Mazier, S., Kopajtic, T., Shi, L., Katz, J. L., Tanda, G. & Newman, A. H., Sep 2012, In: Biological Psychiatry. 72, 5, p. 405-13 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

    Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S., Gether, Ulrik, Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Gellman, S. H., 27 Jul 2012, In: Chemistry: A European Journal. 18, 31, p. 9485-90 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  110. Published

    Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

    Sørensen, G., Jensen, M., Weikop, Pia, Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  111. 2011
  112. Published

    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

    Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.

    Research output: Contribution to journalJournal articlepeer-review

  113. Published

    The binding sites for benztropines and dopamine in the dopamine transporter overlap

    Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  114. 2010
  115. Published

    Tandem Facial Amphiphiles for Membrane Protein Stabilization

    Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  116. Published

    Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

    Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  117. 2009
  118. Published

    Neurotransmitter transporters: structure and function

    Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & Francis

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  119. 2008
  120. Published

    An intracellular interaction network regulates conformational transitions in the dopamine transporter.

    Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  121. Published

    The binding sites for cocaine and dopamine in the dopamine transporter overlap.

    Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  122. 2007
  123. Published

    Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

    Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  124. 2006
  125. Published

    Regulation of dopamine transporter trafficking by intracellular amphetamine.

    Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  126. 2005
  127. Published

    Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

    Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  128. Published

    Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8

    Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  129. 2004
  130. Published

    Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding

    Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  131. Published

    Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters

    Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  132. Published

    Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding

    Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38

    Research output: Contribution to journalJournal articlepeer-review

  133. Published

    Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions

    Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36

    Research output: Contribution to journalJournal articlepeer-review

  134. 2003
  135. Published

    Probing dopamine transporter structure and function by Zn2+-site engineering

    Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  136. Published

    Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  137. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  138. Published

    Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine

    Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96

    Research output: Contribution to journalJournal articlepeer-review

  139. Published

    N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization

    Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000

    Research output: Contribution to journalJournal articlepeer-review

  140. Published

    Probing dopamine transporter structure and function y Zn2+ site engineering

    Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97

    Research output: Contribution to journalReviewpeer-review

  141. 2002
  142. Published

    Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  143. Published

    Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

    Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8

    Research output: Contribution to journalJournal articlepeer-review

  144. 2001
  145. Published

    Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

    Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198

    Research output: Contribution to journalJournal articlepeer-review

  146. Published

    Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

    MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485

    Research output: Contribution to journalJournal articlepeer-review

  147. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846

    Research output: Contribution to journalJournal articlepeer-review

  148. 2000
  149. Published

    Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

    Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  150. 1999
  151. Published

    Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

    Loland, Claus Juul, Norregaard, L. & Gether, Ulrik, 1999, In: Journal of Biological Chemistry. 274, 52, p. 36928-34 6 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 4359