Claus Juul Løland

Claus Juul Løland

Professor


  1. 2024
  2. Published

    Exploring the K+ binding site and its coupling to transport in the neurotransmitter: sodium symporter LeuT

    Schmidt, Solveig Gaarde, Nygaard, Andreas, Mindell, J. A. & Loland, Claus Juul, 2024, In: eLife. 12, 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

    Okorom, A. V., Camacho-Hernandez, G. A., Salomon, Kristine Walløe, Lee, K. H., Ku, T. C., Cao, J., Won, S. J., Friedman, J., Lam, J., Paule, J., Rais, R., Klein, B., Xi, Z. X., Shi, L., Loland, Claus Juul & Newman, A. H., 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 709-727 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

    Yoon, S., Bae, H. E., Hariharan, P., Nygaard, Andreas, Lan, B., Woubshete, M., Sadaf, A., Liu, X., Loland, Claus Juul, Byrne, B., Guan, L. & Chae, P. S., 2024, In: Bioconjugate Chemistry. 35, 2, p. 223–231 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Series of (([1,1′-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity

    Ku, T. C., Cao, J., Won, S. J., Guo, J., Camacho-Hernandez, G. A., Okorom, A. V., Salomon, Kristine Walløe, Lee, K. H., Loland, Claus Juul, Duff, H. J., Shi, L. & Newman, A. H., 2024, In: ACS Pharmacology and Translational Science. 7, 2, p. 515-532 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journalEditorialpeer-review

  7. 2023
  8. Published

    Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

    Salomon, K., Abramyan, A. M., Plenge, P., Wang, L., Bundgaard, C., Bang-Andersen, B., Loland, Claus Juul & Shi, L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 41, 10 p., e2304089120.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance

    Ghani, L., Kim, S., Ehsan, M., Lan, B., Poulsen, I. H., Dev, C., Katsube, S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X., Im, W. & Chae, P. S., 2023, In: Chemical Science. 14, 45, 11 p., 13014.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Persistent binding at dopamine transporters determines sustained psychostimulant effects

    Niello, M., Sideromenos, S., Gradisch, R., O'Shea, R., Schwazer, J., Maier, J., Kastner, N., Sandtner, W., Jäntsch, K., Lupica, C. R., Hoffman, A. F., Lubec, G., Loland, Claus Juul, Stockner, T., Pollak, D. D., Baumann, M. H. & Sitte, H. H., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, 11 p., e2114204120.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published
  12. Published

    Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

    Ghani, L., Zhang, X., Munk, C. F., Hariharan, P., Lan, B., Yun, H. S., Byrne, B., Guan, L., Loland, Claus Juul, Liu, X. & Chae, P. S., 2023, In: Bioconjugate Chemistry. 34, 4, 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2022
  14. Published

    3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability

    Lee, H. S., Das, M., Mahler, F., Ahmed, W., Wang, H., Mortensen, Jonas Sigurd, Hariharan, P., Ghani, L., Byrne, B., Guan, L., Loland, Claus Juul, Keller, S. & Chae, P. S., 2022, In: Chemistry - An Asian Journal. 17, 24, 9 p., e202200941.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

    Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, In: Plant Journal. 111, 4, p. 936-953 15866.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study

    Lee, H. J., Ehsan, M., Zhang, X., Katsube, S., Munk, C. F., Wang, H., Ahmed, W., Kumar, A., Byrne, B., Loland, Claus Juul, Guan, L., Liu, X. & Chae, P. S., 2022, In: Chemical Science. 13, p. 5750-5759 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, Solveig Gaarde, Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization

    Ghani, L., Kim, S., Wang, H., Lee, H. S., Mortensen, Jonas Sigurd, Katsube, S., Du, Y., Sadaf, A., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W., Chae, P. S. & Ahmed, W., 2022, In: Chemistry: A European Journal. 28, 21, 9 p., e202200116.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study

    Ehsan, M., Wang, H., Katsube, S., Munk, C. F., Du, Y., Youn, T., Yoon, S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2022, In: ChemBioChem. 23, 7, e202200027.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

    Pugh, Ciara Frances, DeVree, B. T., Schmidt, Solveig Gaarde & Loland, Claus Juul, 2022, In: Cells. 11, 23, 15 p., 3811.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT

    Calugareanu, D., Möller, I. R., Schmidt, Solveig Gaarde, Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, Solveig Gaarde, Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Visualizing the binding mode of the antidepressant vilazodone on the serotonin transporter by cryo-EM

    Kalenderoglou, I. E., Plenge, P., Yang, D., Salomon, K., Laursen, L., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2022, In: Biophysical Journal. 121, 3, p. 26-26 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  24. 2021
  25. Published

    Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

    Sadaf, A., Kim, S., Bae, H. E., Wang, H., Nygaard, Andreas, Uegaki, Y., Du, Y., Munk, C. F., Katsube, S., Lee, H. S., Bae, J., Choi, C. W., Choi, H., Byrne, B., Gellman, S. H., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W. & Chae, P. S., 2021, In: Acta Biomaterialia. 128, p. 393-407 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability

    Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

    Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

    Plenge, P., Yang, D., Salomon, K., Laursen, L., Kalenderoglou, I. E., Newman, A. H., Gouaux, E., Coleman, J. A. & Loland, Claus Juul, 2021, In: Nature Communications. 12, 1, 12 p., 5063.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

    Targowska-Duda, K. M., Budzynska, B., Michalak, A., Wnorowski, A., Loland, Claus Juul, Maj, M., Manetti, D., Romanelli, M. N., Jozwiak, K., Biala, G. & Arias, H. R., 2021, In: European Neuropsychopharmacology. 52, p. 31-47 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. 2020
  31. Published

    Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

    Niello, M., Gradisch, R., Loland, Claus Juul, Stockner, T. & Sitte, H. H., 2020, In: Trends in Pharmacological Sciences. 41, 7, p. 446-463 18 p.

    Research output: Contribution to journalReviewpeer-review

  32. Published

    Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study

    Das, M., Mahler, F., Hariharan, P., Wang, H., Du, Y., Mortensen, Jonas Sigurd, Patallo, E. P., Ghani, L., Glück, D., Lee, H. J., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K., Keller, S. & Chae, P. S., 2020, In: Journal of the American Chemical Society. 142, 51, p. 21382–21392 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability

    Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization

    Bae, H. E., Cecchetti, C., Du, Y., Katsube, S., Mortensen, Jonas Sigurd, Huang, W., Rehan, S., Lee, H. J., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2020, In: Acta Biomaterialia. 112, p. 250-261 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

    Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, Solveig Gaarde, Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Short-Range Distance Measurement by Transition Metal Ion FRET

    Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  37. Published

    Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

    Slack, R. D., Ku, T. C., Cao, J., Giancola, J. L. B., Bonifazi, A., Loland, Claus Juul, Gadiano, A., Lam, J., Rais, R., Slusher, B. S., Coggiano, M., Tanda, G. & Newman, A. H., 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2343-2357 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

    Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.

    Research output: Contribution to journalJournal articlepeer-review

  40. 2019
  41. Published

    Conformational dynamics of the human serotonin transporter during substrate and drug binding

    Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization

    Ghani, L., Munk, C. F., Zhang, X., Katsube, S., Du, Y., Cecchetti, C., Huang, W., Bae, H. E., Saouros, S., Ehsan, M., Guan, L., Liu, X., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2019, In: Journal of the American Chemical Society. 141, 50, p. 19677-19687 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

    Bae, H. E., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Kumar, K. K., Ha, B., Das, M., Lee, H. S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemical Science. 10, 4, p. 1107-1116

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability

    Sadaf, A., Ramos, M., Mortensen, Jonas Sigurd, Du, Y., Bae, H. E., Munk, C. F., Hariharan, P., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 2019, In: ACS chemical biology. 14, 8, p. 1717-1726 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments

    Möller, I. R., Slivacka, M., Hausner, J., Nielsen, A. K., Pospisilova, E., Rand, Kasper Dyrberg, Liskova, R., Polak, M., Loland, Claus Juul, Kadek, A., Man, P. & Rand, Kasper Dyrberg, 2019, In: Analytical Chemistry. 91, 17, p. 10970-10978 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Preface: Special issue on neurotransmitter transporters

    Chaudhry, F. A., Loland, Claus Juul, Ortega, A. & Schousboe, Arne, 2019, In: Neuropharmacology. 161, 1 p., 107859.

    Research output: Contribution to journalEditorialpeer-review

  47. Published

    Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

    Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

    Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journalConference abstract in journalpeer-review

  50. Published

    Substrate-induced conformational dynamics of the dopamine transporter

    Nielsen, A. K., Möller, I. R., Wang, Yong, Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 2019, In: Organic & Biomolecular Chemistry. 17, 12, p. 3249-3257 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. 2018
  53. Published

    An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Bae, H. E., Byrne, B., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 11 Jul 2018, In: Chemistry - A European Journal. 24, 39, p. 9860-9868 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

    Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

    Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

    Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability

    Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.

    Research output: Contribution to journalJournal articlepeer-review

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