Research projects

Background: How is the brain supplied with food for thoughts?
And what goes wrong when we age, or suffer from a neurodegenerative disorder?

Normal brain function depends on preserved supply of glucose and oxygen and even minor deficits in control of the cerebral circulation lead to loss of brain function. The robust coupling between brain activity and cerebral blood flow (CBF), the so-called neurovascular coupling regulates the minor local CBF alterations that take place all the time. In the past, the dynamics of CBF control was based on an understanding of brain arterioles and on capillaries for exchange of substances between blood and brain.  This notion has undergone an important change in recent years because it has been discovered that both arterioles and capillaries take part in 1) substance exchange and 2) cerebrovascular resistance. 



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