Department of Neuroscience
The Panum Institute, room 33-3-84
Phone: +45 3152 6540
The aim of the research is to understand how neurons in small assemblies interact to produce sensory and motor functions in the brain.
The aim of the research is to understand how neurons in small assemblies interact to produce sensory and motor functions in the brain. A variety of electrophysiological and optical techniques are used to study living neurons in preparations of nervous tissue that maintain functional sensorimotor systems under in vitro conditions. We seek to answer fundamental questions such as: What neural microcircuit mechanisms in the brainstem are involved in generating breathing movements? How do sensory and motor systems produce precision movements? What developmental processes are involved in specifying functional microcircuits? Ultimately we wish to contribute to an understanding of how brain function emerges from network interactions between individual neurons.
En-block brainstem, acute slice, and slice culture preparations from newborn mice are used to study the cellular and system properties of respiratory neurons with the aim of understanding how breathing rhythm is generated.
Spontaneous respiratory activity on hypoglossal and cervical nerves in an in vitro brainstem-spinal cord preparation from postnatal mice.
Slice and whole-mount preparations from newborn mice are used to study coordinated calcium activity in neighboring groups of neurons with the aim of understanding early developmental specification of neural function.
Processing of sensory information and cerebellar function
Slice preparations from the inferior olive from newborn mice are used to study spontaneous coordinated activity in clusters of inferior olive neurons with the aim of understanding early olivocerebellar development and function. The internal processing in the cerebellar cortex is analyzed in the intact cerebellum. Of particular focus is the inner workings of mossy fibers, and the Golgi cell inhibitory control of the mossy fiber-granule cell synapse in the input layer of the cerebellar cortex.
Detection of clusters in the inferior olivary nucleus in a slice from postnatal mice. Movie showing concurrent image stacks of original Fluo-8, AM data, ∆F/F and 1 frame subtraction, and three stages of an automatic cluster detection algorithm as described in our 2013 paper in J. Physiol.
We are currently looking for students interested in doing their Bachelor, Master, or PhD project in our group. We will actively support the application of suitable students for scholarships from various sources. The projects might include both electrophysiological, optical and molecular biology techniques. If you are interested in becoming a member of our team, please contact:
Jens C. Rekling
phone: +45 3152 6540