Publication list – University of Copenhagen

Publication list

Jakob Balslev Sørensen
ORCID: 0000-0001-5465-3769

Contribution to several high-impact papers, incl. 1x Science, 3x Cell, 1x Neuron, 1x PLoS Biology, 7x PNAS, 4x EMBO J., 4x Elife, 11x J. Neurosci. Scientometry: >4700 citations, H-index = 34, i10-indeks = 56 (Google Scholar).


68. Kádková A., Radecke J., and Sørensen J.B. (2018). The SNAP-25 protein family. Neuroscience. Sep 27. pii: S0306-4522(18)30618-3. (Invited review)


67. Houy S., Groffen A.J., Ziomkiewicz I., Verhage M., Pinheiro P.S., and Sørensen J.B. (2017). Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. Elife 6. pii: e27000.

66. Walter A.M.*,Müller R., Tawfik B., Wierda K.D.B., Pinheiro P.S., Nadler A., McCarthy A.W., Ziomkiewicz I.,  Kruse M., Reither G., Rettig J., Lehmann M., Haucke V., Hille B., Schultz C.* and Sørensen J.B.* (2017) Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. (*: corresponding authors). Elife 6: e30203.

65. Hussain S., Egbenya D.L., Lai Y.-C., Dosa Z.J., Sørensen J.B., Anderson A.E., and Davanger S. (2017). The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines. Hippocampus July 7. doi: 10.1002/hipo.22761.

64. Berg R.W., Stauning M.T., Sørensen J.B. and Jahnsen H. (2017). Comment on ’Penetration of Action Potentials During Collision in the Median and Lateral Giant Axons of Invertebrates’. Phys. Rev. X. 7, 028001.

63. Sørensen J.B. (2017). Ride the wave: retrograde trafficking becomes Ca2+-dependent with BAIAP3. J. Cell Biol. Jun 16. pii: jcb.201706007 (”spotlight” commentary).


62. Schupp M., Malsam, J., Ruiter M., Scheutzow A., Wierda K.D.B., Söllner T.H., and Sørensen J.B. (2016). Interactions between SNAP-25 and synaptotagmin-1 are involved in vesicle priming, clamping spontaneous and eliciting evoked neurotransmission. J. Neurosci. 36:11865-11880.

61. Pinheiro P.S., Houy S., and Sørensen J.B. (2016). C2-domain containing calcium sensors for neuroendocrine secretion. J. Neurochem. 139:943-958.

60. Toft-Bertelsen T.L., Ziomkiewicz I., Houy S., Pinheiro P.S., and Sørensen J.B. (2016). Regulation of Ca2+-channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol. Biol. Cell. 27:3329-3341.

59. Munch A.S., Kedar G.H., van Weering J.R.T., Vazquez-Sanchez S., Enqi H., André T., Braun T., Söllner T.H., Verhage M., and Sørensen J.B. (2016). Extension of helix 12 in Munc18-1 induces vesicle priming. J. Neurosci. 36:6881-6891.

58. de Jong A.P., Meijer M., Saarloos, I., Cornelisse L.N., Toonen R.F. Sørensen J.B. and Verhage M. (2016). Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity. Proc. Natl. Acad. Sci. (USA) 113:5095-5100.


57. Man K.M., Imig C., Pinheiro P.S., Stevens D.R., Rettig J., Sørensen J.B.,  Cooper B.H., Brose N., and Wojcik SM. (2015). Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Elife 4:e10635.

56. Kedar G., Munch A.S., van Weering J., Malsam J., Scheutzow A., de Wit H., Houy S., Tawfik B., Söllner T.H., Sørensen J.B., and Verhage M. (2015). A post-docking role of Synaptotagmin1-C2B domain bottom residues R398/399 in mouse chromaffin cells. J. Neurosci. 35: 14172-14182.

55. Schotten S., Meijer M., Walter A.M., Huson V., Mamer L., Kalogreades L., ter Veer M., Ruiter M., Brose N., Rosenmund C., Sørensen J.B.*, Verhage M.*, and Cornelisse L.N.* (2015). Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate. *Equal contributions. Elife 4:e05531.

54. Milosevic I., and Sorensen J.. (2015). Fusion machinery: SNARE protein complex. In: Presynaptic terminals, edited by Sumiko Mochida, Springer, Germany.

53. Antoku Y., Dedecker P., Pinheiro P.S., Vosch T., and Sørensen J.B. (2015). Spatial distribution and temporal evolution of DRONPA-fused SNAP25 clusters in adrenal chromaffin cells. Photochemical & Photobiological Sciences 14:1005-1012.


52. Weber J.P., Toft-Bertelsen T.L., Mohrmann R., Delgado-Martinez I, and Sørensen J.B. (2014). Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23. PLoS One 9: e114033.

51. Pinheiro P.S., Jansen A.M., de Wit H., Tawfik B., Madsen K.L., Verhage M., Gether U., and Sørensen J.B. (2014). The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. J. Neurosci. 34,10688-10700.

50. Walter A.M., Kurps J., de Wit H., Schöning S., Toft-Bertelsen T.L., Lauks J., Ziomkiewicz I., Ngatchou Weiss A., Schulz A., Fischer von Mollard G., Verhage M., and Sørensen J.B. (2014). The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J 33,1681-1697.

49. Wierda K.D.B., and Sørensen J.B. (2014). Innervation by a GABAergic neuron depresses spontaneous release in glutamatergic neurons and unveils the clamping phenotype of synaptotagmin-1. J. Neurosci. 34, 2100-2110.


48. Walter A.M., Pinheiro P.S., Verhage M., and Sørensen J.B. (2013). A sequential vesicle pool model with a single release sensor effectively explains complex Ca2+-dependent properties of neurosecretion. PLoS Computational Biology 9, e1003362.

47. Pinheiro P.S., De Wit H., Walter A.M., Groffen A.J., Verhage M., and Sørensen J.B. (2013). Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release. J. Neurosci. 33, 16459-16470 

46. Mohrmann R., De Wit H., Connell E., Pinheiro P.S., Leese C., Bruns D., Davletov B., Verhage M., and Sørensen J.B. (2013). Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering. J. Neurosci. 33, 14417-14430.


45. Mohrmann R., and Sørensen J.B. (2012). SNARE requirements en route to exocytosis: from many to few. J. Mol. Neurosci. 48:387-394.


44. Walter A.M., Groffen A.J., Sørensen J.B., and Verhage M. (2011): Multiple Ca(2+) sensors in secretion: teammates, competitors or autocrats? Trends Neurosci. 34:487-497.


43. Ngatchou A.N., Kisler K., Fang Q., Walter A.M., Zhao Y., Sørensen J.B., and Lindau M. (2010). Role of the synaptobrevin C-terminus in fusion pore formation. Proc. Natl. Acad. Sci. (USA)  107, 18463-18468.

42. Mohrmann R., De Wit H., Verhage M., Neher E., and Sørensen J.B. (2010). Fast vesicle fusion in living cells requires at least three SNARE-complexes. Science 330, 502-505.

41. Schonn J.S., van Weering J.R.T., Mohrmann R., Schlüter O.M., Südhof T.C., de Wit H., Verhage M., and Sørensen J.B. (2010). Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic 11, 1415-1428.

40. Weber J.P., Reim K., and Sørensen J.B. (2010). Opposing roles of two sub-domains of the SNARE-complex in neurotransmission. EMBO J. 29, 2477-2490.

39. Wiederhold K., Kloepper T.H., Walter A.M., Stein A., Kienle N., Sørensen J.B., and Fasshauer D. (2010). A coiled-coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex. J. Biol. Chem. 285, 21549-21559.

38. Walter A.M., Wiederhold K., Bruns D., Fasshauer D., and Sørensen J.B. (2010). Synaptobrevin N-terminally bound to SNAP-25:syntaxin defines the primed vesicle state in regulated exocytosis. J. Cell Biol. 188, 401-413.


37. Sørensen J.B. (2009). Conflicting views on the membrane fusion machinery and the fusion pore. Annu. Rev. Cell Dev. Biol. 25, 513-537.

36. De Wit H., Walter A.M., Milosevic I., Gulyás-Kovács A., Sørensen J.B.*, and Verhage M.* (2009). Synaptotagmin docks secretory vesicles to SNAP-25:syntaxin dimers. Cell 138, 935-946. (*Shared last-authorship).

35. Sørensen J.B. (2009). Vesicle pools. Chapter 1384 in: New Encyclopedia for Neuroscience, edited by Larry Squire et al., Elsevier, Oxford, UK.


34. Cai H., Reim K., Varoqueaux F., Tapechum S., Hill K., Sørensen J.B., Brose N., and Chow R.H. (2008). Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proc. Natl. Acad. Sci. (USA) 105, 19538-19543.

33. Fang Q., Berberian K., Gong L.W., Hafez I., Sørensen J.B., and Lindau M. (2008). The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics. Proc. Natl. Acad. Sci. (USA) 105, 15388-15392.

32. Nagy G., Milosevic I., Mohrman, R., Wiederhold K., Walter A.M., and Sørensen J.B. (2008). The SNAP-25 linker as an adaptation towards fast exocytosis. Mol. Biol. Cell 19, 3769-3781.

31. Sørensen J.B., and Verhage, M. (2008). Vesicle docking in regulated exocytosis. Traffic 9, 1414-1424.

30. Schonn J.S., Maximov A., Lao Y., Südhof T.C., and Sørensen J.B. (2008). Synaptotagmin-7 and -1 are functionally overlapping calcium sensors for exocytosis in adrenal chromaffin cells. Proc. Natl. Acad. Sci. (USA) 105, 3998-4003.

29. Maximov A., Lao Y., Li H., Chen X., Rizo J., Sørensen J.B., and Südhof T.C. (2008). Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proc. Natl. Acad. Sci. (USA) 105, 3986-3991.


28. Jockusch W.J., Speidel D., Sigler A., Sørensen J.B., Varoqueaux F., Rhee J.-S., and Brose N. (2007). CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131, 796-808.

27. Delgado-Martinez I., Nehring R., and Sørensen J.B. (2007). Differential abilities of SNAP-25 homologues to support neuronal function. J. Neurosci. 27, 9380-9391.

26. Gulyás-Kovács A., de Wit H., Kochubey O., Milosevic I., Toonen R., Klingauf J., Verhage M., and Sørensen J.B. (2007). Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J. Neurosci. 27, 8676-8686.


25. Zilly F., Sørensen J.B., Jahn R., and Lang T. (2006). Munc-18-1 binding to syntaxin 1 allows for the initiation of the neuronal SNARE-zipper in native membranes. PLoS Biology 4(10), e330 doi:10.1371/journal.pbio.0040330.

24. Nili U., de Wit H., Gulyás-Kovács A., Toonen R.F., Sørensen J.B., Verhage M., and  Ashery U. (2006). Munc18-1 phosphorylation by PKC potentiates vesicle pool replenishment in bovine chromaffin cells. Neuroscience 143, 487-500.

23. Toonen R.F., Kochubey O., de Wit H., Gulyas-Kovacs A., Konijnenburg B., Sørensen J.B., Klingauf J., and Verhage M. (2006). Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J. 25, 3725-3737.

22. Sørensen J.B., Wiederhold K., Müller E.M., Milosevic I., Nagy G., de Groot B.L., Grubmüller H., and Fasshauer D. (2006). Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J. 25, 955-966.

21. Nagy G., Kim J.H., Pang Z.P., Matti U., Rettig J., Sudhof T.C., and Sørensen J.B. (2006). Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. J Neurosci. 26, 632-643.


20. Nagy G., Milosevic I., Fasshauer D., Muller E.M., de Groot B.L., Lang T., Wilson M.C., and Sørensen J.B. (2005). Alternative Splicing of SNAP-25 Regulates Secretion through Nonconservative Substitutions in the SNARE Domain. Mol. Biol. Cell 16, 5675-5685

19. Milosevic I., Sørensen J.B.*, Lang T., Krauss M., Nagy G., Haucke V., Jahn R., and Neher E. (2005). Plasmalemmal PI(4,5)P2 level regulates the releasable vesicle pool size in chromaffin cells. J. Neurosci. 25, 2557-2565. (*Corresponding author)

18. Sørensen J.B. (2005). SNARE complexes prepare for membrane fusion. Trends Neurosci. 28, 453-455.


17. Nagy G., Reim K., Matti U., Brose N., Binz T., Rettig J., Neher E., and Sørensen,J.B. (2004). Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron 41, 351-365.

16. Sørensen J.B. (2004). Formation, stabilisation and fusion of the readily-releasable pool of secretory vesicles. Pflügers Arch. - Eur. J. Physiol. 448, 347-362.


15. Sørensen J.B., Fernandez-Chacon R., Südhof T.C., and Neher E. (2003). Examining synaptotagmin I function in dense core vesicle exocytosis under direct control of Ca2+. J. Gen. Physiol. 122, 265-276.

14. Sørensen J.B.*, Nagy G.*, Varoqueaux F., Nehring R.B., Brose N., Wilson M.C., and Neher E. (2003). Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23. Cell 114, 75-86. (*Shared first authorship)

13. Brede M., Nagy G., Phillip M., Sørensen J.B., Lohse M.J., and Hein L. (2003). Differential control of adrenal and sympathetic catecholamine release by a2-receptor subtypes. Mol. Endocrinol. 17, 1640-1646.


12. Nagy G., Matti U., Nehring R.B., Binz T., Rettig J., Neher E., and Sørensen J.B. (2002) Protein kinase C-dependent phosphorylation of synaptosome-associated protein of 25 kDa at Ser187 potentiates vesicle recruitment. J. Neurosci. 22, 9278-9286.

11. Sørensen J.B., Matti U., Wei S., Nehring R.B., Voets T., Ashery U., Binz T., Neher E., and Rettig J. (2002). The SNARE protein SNAP-25 is linked to fast calcium-triggering of exocytosis. Proc Natl Acad Sci U S A. 99, 1627-1632.

10. Larsen E.H., Sørensen J.B., and Sørensen, J.N. (2002). Analysis of the sodium recirculation theory of solute coupled water transport in small intestine. J. Physiol. 542, 33-50.


9. Sørensen J.B.*, Nielsen M.S.*, Gudme C.N., Larsen E.H., and Nielsen R. (2001). Maxi K+ channels co-localised with CFTR in the apical membrane of an exocrine gland acinus: Possible involvement in macroscopic secretion. Pflügers Arch. - Eur. J. Physiol. 442, 1-11. (*Shared first-authorship)


8. Larsen E.H., Sørensen J.B., and Sørensen J.N. (2000). A mathematical model of solute coupled water transport in leaky epithelia incorporating recirculation of the actively transported solute. J. Gen. Physiol. 116, 101-124.

7. Sørensen J.B., Cha A., Latorre R., Rosenmann E., and Bezanilla F. (2000). Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups outside S4. J. Gen. Physiol. 115, 209-221.


6. Sørensen J.B., and Larsen E.H. (1999). Membrane potential and conductance of frog skin gland acinar cells in resting conditions and during stimulation with agonists of macroscopic secretion. Pflügers Arch. - Eur. J. Physiol. 439, 101-112.


5. Sørensen J.B., and Larsen E.H. (1998). Patch-clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channel activated by cAMP. J. Gen. Physiol. 112, 19-31.


4. Sørensen J.B., and Larsen E.H. (1996). Heterogeneity of chloride channels in the apical membrane of isolated mitochondria-rich cells from toad skin. J. Gen. Physiol. 108, 421-433.

3. Larsen E.H., Christoffersen B.C., Jensen L.J., Sørensen J.B. & Willumsen N.J. (1996). Role of mitochondria-rich cells for epithelial chloride uptake. Exp Physiol. 81, 525-534.

2. Larsen E.H., Jensen L.J., Jespersen Å., Møbjerg N., Sørensen J.B., and Willumsen N.J. (1996). Chloride channels of mitochondria-rich cells in anuran skin: Physiological significance and regulation. Zoology 99, 227-236.


1. Bildsøe M., and Sørensen J.B. (1994). A method of model­ling time dependent data: swimming in guppies (Poecilia reti­culata) under threat of a predator. Behavioural Processes 31, 75-96.