Publication List

David P. D. Woldbye

108. Wickham J, Brödjegård NG, Vighagen R, Pinborg LH, Bengzon J, Woldbye DPD, Kokaia M & Andersson M (2018) Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery. Scientific Reports 8:4158.

107. Olesen MV, Gøtzsche CR, Christiansen SH, Woldbye DPD (2018) Differential plastic changes in synthesis and binding in the brain somatostatin system after electroconvulsive stimulation in mice. Acta Neuropsychiatrica 21:1-11.

106. Diaz-delCastillo M, Christiansen SH, Appel CK, Falk S, Woldbye DP, Heegaard A-M (2018) Neuropeptide Y is up-regulated and induces antinociception in cancer-induced bone pain. Neuroscience (in press).

105. Christiansen AT, Sørensen NB, Haanes KA, Blixt FW, la Cour M, Warfvinge K, Klemp K, Woldbye DPD, Kiilgaard JF (2018) Neuropeptide Y treatment induces retinal vasoconstriction and causes functional and histological retinal damage in a porcine ischemia model. Acta Ophthalmologica (in press).

104. Christiansen AT, Kiilgaard JF, Klemp K, Woldbye DPD, Hannibal J (2018) Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas  –  a comparative study. J Comp Neurol Apr 17 [Epub ahead of print].

103. Campos EJ, Martins J, Brudzewsky D, Correia S, Santiago AR, Woldbye DPD, Ambrósio AF (2018) The impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina. Clin Exp Ophthalmol Clin Exp Ophthalmol. Feb 14 [Epub ahead of print].

102. Axelsen TM, Woldbye DPD (2018) Gene therapy for Parkinson’s disease, an update. J Parkinson’s Dis (in press).

101. Skov LJ, Jensen M, Christiansen SH, Ratner C, Woldbye DPD, Holst B (2017) Exploring the behavioral and metabolic phenotype generated by re-introduction of the ghrelin receptor in the ventral tegmental area. Int J Mol Sci 18:5.

100. Jørgensen SH, Fitzpatrick CM, Woldbye DP, Sørensen AT (2017) Chemogenetic modulation of G-protein coupled receptor signalling in visual attention research. Acta Pharm Toxicol 121:373-81.

99.  Fitzpatrick CM, Caballero-Pulvinerio M, Gether U, Habekost T, Bundesen C, Vangkilde S, Woldbye DPD, Andreasen JT, Petersen A (2017) Theory of visual attention (TVA) applied to mice in the 5-choice serial reaction time task. Psychopharmacology 234:845-55. Woldbye, Andreasen, and Petersen shared last author.

98.  Diaz-delCastillo M, Woldbye DPD, Heegaard AM (2017) Neuropeptide Y its involvement in chronic pain. Neuroscience S0306-4522(17)30626-7.

97.  Caballero-Puntiverio M, Fitzpatrick CM, Woldbye DP, Andreasen JT (2017) Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-choice serial reaction time task. J Psychopharm 31:272-83.

96.  Wei YB, Melas PA, Villaescusa JC, Liu JJ, Xu N, Christiansen SH, Elbrønd-Bek H, Woldbye DP, Wegener G, Mathé AA, Lavebratt C (2016) MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro. Int J Neuropsychopharmacol 19:1-9.

95.  Nikitidou L, Christiansen SH, Gøtzsche CR, Cifra A, Woldbye DPD, Kokaia M (2016) Translational gene therapy for chronic epilepsy: unilateral overexpression of neuropeptide Y and Y2 receptors. Neurobiol Dis 86:52-61.

94.  Møller LLV, Sylow L, Gøtzsche CR, Serup AK, Christiansen SH, Weikop P, Kiens B, Woldbye DPD, Richter EA (2016) Decreased spontaneous activity in AMPK α2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism. Physiol Beh 164:300-5.

93.  Johansson I, Woldbye D (2016) Kliniske aspekter relateret til ADHD-lægemidlers forskellige virkningsmekanismer. Best Practise in Psychiatry 8:18-23.

92.  Jensen M, Rudenko O, Christiansen SH, Skov LJ, Ratner C, Woldbye DPD, Holst B (2016) Anxiolytic-like effects of increased ghrelin receptor signaling in the amygdala. Int J Neuropsychopharmacol 19:1-12.

91.  Howe AS, Buttenschøn HN, Bani-Fatemi A, Maron E, Otowa T, Erhardt A, Binder EB, Gregersen NO, Mors O, Woldbye DP, Domschke K, Deckert J, Reif A, Shlik J, Kõks S, Kawamura Y, Miyashita A, Kuwano R, Tokunaga K, Tanii H, Sasaki T, Smoller JW, De Luca V (2016) Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Mol Psychiatry 21:665-79.

90.  Gøtzsche CR, Woldbye DPD (2016) The role of NPY in learning and memory. Neuropeptides 55:79-89.

89.  Gregersen NO, Buttenschøn HN, Hedemand A, Nielsen MN, Dahl HA, Kristensen AS, Johansen O, Woldbye DP, Erhardt A, Kruse TA, Wang AG, Børglum AD, Mors O (2016). Association between genes on chromosome 19p13.2 and panic disorder. Psychiatr Genet 26:287-92.

88.  Avaliani N, Andersson M, Runegaard A, Woldbye D, Kokaia M (2016) DREADDs suppress seizure-like activity in mouse model of pharmacoresistant epileptic brain tissue. Gene Therapy 23:760-76.

87.  Andersson M, Avaliani N, Svensson A, Wickham J, Pinborg LH, Jespersen B, Christiansen SH, Bengzon J, Woldbye DPD, Kokaia M (2016) Optogenetic control of human neurons in organotypic brain cultures. Scientific Reports 6:24818.

86.  Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B; Tralhão P, Gøtzsche CR, Cavadas C, Castelo-Branco M, Woldbye DP, Picaud S, Santiago AR, Ambrosio AF (2015) Activation of neuropeptide Y receptors modulates retinal ganglion cell physiology, and exerts neuroprotective actions in vitro. ASN Neuro 7:1-21.

85.  Ledri, M and Sørensen AT, Christiansen SH, Nikitidou L, Madsen MG, Cifra A, Bengzon J, Skagerberg G, Englund E, Lindberg E, Pinborg LH, Jespersen B, Gøtzsche CR, Woldbye DPD, Andersson M, Kokaia M (2015) Differential effect of neuropeptides on excitatory synaptic transmission in the human epileptic hippocampus. J Neuroscience 35:9622-31.

84.  Elbrønd-bek H, Skinbjerg M, Christensen DZ, Plenge P, Woldbye DPD (2015) Visualization of functional neuropeptide Y receptors in the mouse hippocampus and neocortex using [35S]GTPγS binding. Int J Pept Res Ther 21(3).

83.  Dyrvig M, Gøtzsche CR, Woldbye DP, Lichota J (2015) Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat. Mol Cell Neurosci 67:137-43.

82.  Axelsen TM, Navntoft CAE, Christiansen SH, Dreyer JK, Sørensen JB, Gether U, Woldbye DPD (2015) [Optogenetics brings hidden neural mechanisms into the light and could become a future therapy]. Ugeskr Laeger 177(34).

81.  Sørensen G, Bak-Jensen HH, Brennum LT, Bundgaard C, Montezinho LCR, Mørk A, Wörtwein G, Woldbye DPD (2014) Addiction-related effects of DOV 216,303 and cocaine: a comparative study in the mouse. Basic Clin Pharm Tox 114:451-9.

80.  Gregersen NO, Buttenschøn HN, Hedemand A, Dahl HA, Kristensen AS, Clementsen B, Woldbye DPD, Koefoed P, Erhardt A, Kruse TA, Wang AG, Børglum AD, Mors O (2014) Are TMEM genes potential candidate genes for panic disorder? Psychiatr Genet 24:37-41.

79.  Elbrønd-Bek H, Olling JD, Gøtzsche CR, Waterfield A, Wörtwein G, Woldbye DPD (2014) NPY-stimulated [35S]GTPγS functional binding is reduced in the hippocampus after kainate-induced seizures in mice. Synapse 68:427-36.

78.  Dyrvig M, Christiansen SH, Woldbye DPD, Jacek Lichota (2014) Temporal gene expression profile after acute electroconvulsive stimulation in the rat. Gene 539:8-14.

77.  Christiansen SH, Olesen MV, Gøtzsche CR, Woldbye DPD (2014) Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice. Neuropeptides 48:335-44.

76.  Xu R, Pankratova S, Christiansen SH, Woldbye D, Højland A, Bock A, Berezin V (2013) A peptide antagonist of ErbB receptors, Inherbin3, induces neurite outgrowth through ErbB1 inhibition. Neurochem Res 38:2550-8.

75.  Wang AG, Koefoed P, Jacoby AS, Woldbye D, Rasmussen HB, Timm S, Dam H, Jakobsen KD, Nordentoft M, Jürgens G, Sorensen HJ, Garsdal O, Hvid M, Werge T (2013) Neuropeptide Y genes and suicidal behaviour among schizophrenic patients. Psychiatr Genet 23:139-40.

74.  Sørensen G, Wörtwein G, Fink-Jensen A, Woldbye DPD (2013) Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference. Pharm Biochem Beh 105:151-6.

73.  Rickhag M, Owens WA, Winkler M-T, Nørgaard-Strandfelt K, Andresen B, Sørensen G, Madsen KL, Wörtwein G, Woldbye DPD, Sitte H, Daws LC, Gether U (2013) Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. J Biol Chem 288:27534-44.

72.  Rickhag M, Herborg-Henriksen F, Sørensen G, Nørgaard-Strandfelt K, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe Ib, Amendrup-Johnsen I, Eriksen J, Füchtbauer E-M, Gomeza J, Woldbye DPD, Wörtwein G, Gether U (2013) A C-terminal PDZ domain binding sequence is required for striatal distribution of the dopamine transporter. Nature Commun 4:1580.

71.  Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, Stamou D, Kjærulff O, Gether U (2013) PICK1-deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PloS Biology 11:e1001542.

70.  Henningsen K, Woldbye DPD, Wiborg O (2013) Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. Eur Neuropsychopharm 23:1789-94.

69.  Agasse F, Xapelli S, Coronas V, Christiansen SH, Rosa AI, Sardá-Arroyo L, Santos T, Ferreira R, Schitine C, Harnois T, Bourmeyster N, Bragança J, Bernardino L, Malva JO, Woldbye DP (2013) The neuropeptide galanin promotes neuronal differentiation in murine subventricular zone cultures. Stem Cells Dev 22:1693-1708.

68.  Sørensen G, Woldbye DPD (2012) Mice lacking neuropeptide Y show increased sensitivity to cocaine. Synapse 66:840-3.

67.  Sørensen G, Jensen M, Weikop P, Dencker D, Christiansen SH, Loland CJ, Fink-Jensen A, Petersen JH, Wörtwein G, Woldbye DPD (2012) Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. Psychopharmacology 222:565-77.

66.  Olesen MV, Christiansen SH, Gøtzsche CR, Woldbye DPD (2012) Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with moderate anxiolytic-like and proconvulsant effects in mice. J Neurosci Res 90:498-507.

65.  Olesen MV, Christiansen SH, Gøtzsche CR, Holst B, Woldbye DPD (2012) Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity. Neuropeptides 46:71-9.

64.  Koefoed P, Woldbye DPD*, Hansen TvO, Christiansen SH, Mors O, Kessing LV, Werge T, Kaipio K, Pesonen U, Fahmy T, Jørgensen OS, Mellerup E, Jakobsen KD, Hansen ES, Knudsen GM, Bukh JD, Bock C, Lindberg C, Kristensen AS, Dam H, Nordentoft M, Als TD, Wang AG, Gether U, Rehfeld JF, Bolwig TG (2012) Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. Acta Neuropsychiatrica 24:81-90. *Woldbye and Koefoed shared first author.

63.  Gøtzsche CR, Sørensen AT, Nikitidou L, Olesen MV, Sørensen G, Christiansen SH, Ängehagen M, Woldbye DPD* and Kokaia M (2012) Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures. Neurobiol Dis 45:288-96. *Woldbye og Kokaia shared last author.

62.  Gregersen N, Dahl HA, Buttenschøn HN, Nyegaard M, Hedemand A, Als TD, Wang AG, Joensen S, Woldbye DPD, Koefoed P, Kristensen AS, Kruse TA, Børglum A, Mors O (2012) Genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. Eur J Hum Genetics 20:84-90.

61.  Gonçalves SJ, Baptista S, Olesen MV, Fontes-Ribeiro C, Malva JO, Woldbye DP, Silva AP (2012) Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment. J Neurochem 123:1041-53.

60.  Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Müller-Myhsok B, Mors O, Borglum A, Kristensen AS, Woldbye DP, Koefoed P, Eriksson E, Maron E, Metspalu A, Nurnberger J, Philibert RA, Kennedy J, Domschke K, Reif A, Deckert J, Otowa T, Kawamura Y, Kaiya H, Okazaki Y, Tanii H, Tokunaga K, Sasaki T, Ioannidis JP, McMahon FJ, Binder EB (2012) Replication and meta-analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2:e156.

59.  Dyrvig M, Hansen HH, Christiansen SH, Woldbye DP, Mikkelsen JD, Lichota J (2012) Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat. Brain Res Bull 88:507-13.

58.  Dencker D, Weikop P, Sørensen G, Woldbye DPD, Wörtwein G, Wess J, Fink-Jensen A (2012) An allosteric enhancer of M(4) muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine. Psychopharmacology 224:277-87.

57.  Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DPD, Wörtwein G, Fink-Jensen A (2011) Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice. Psychopharmacology 216:367-78.

56.  Fink-Jensen A, Schmidt LS, Dencker D, Schülein C, Wess J, Wörtwein G, Woldbye DPD (2011) Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor. Eur J Pharm 656:39-44.

55.  Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DPD, Wess J, Fink-Jensen A (2011) Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline. J Neuroscience 31:5905-8.

54.  Christiansen SH, Olesen MV, Wörtwein G, Woldbye DPD (2011) Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice. Behav Brain Res 216:585-91.

53.  Buttenschøn HN, Kristensen AS, Buch HN, Andersen JH, Bonde JP, Grynderup M, Hansen AM, Kolstad H, Kærgaard A, Kærlev L, Mikkelsen S, Thomsen JF, Koefoed P, Erhardt A, Woldbye DPD, Børglum AD, Mors O (2011) The norepinephrine transporter gene is a candidate gene for panic disorder. J Neural Transm 118:969-76.

52.  Woldbye DPD, Ängehagen M, Gøtzsche CR, Elbrønd-Bek H, Sørensen AT, Christiansen SH, Olesen MV, Nikitidou L, Hansen TvO, Kanter-Schlifke I, Kokaia M (2010) Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures. Brain 133:2778-88.

51.  Schmidt LS, Miller AD, Lester DB, Bay-Richter C, Schülein C, Schmidt HF, Wess J, Blaha CD, Woldbye DPD, Fink-Jensen A, Wörtwein G (2010) Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice. Psychopharmacology 207:547-58.

50.  Olling JD, Ulrichsen J, Correll M, Woldbye DPD (2010) Gene expression in the neuropeptide Y system during ethanol withdrawal kindling in rats. Alcohol Clin Exp Res 34:462-70.

49.  Koefoed P, Woldbye DPD, Hansen TvO, Hansen ES, Knudsen GM, Bolwig TG, Rehfeld JF (2010) Gene variations in the cholecystokinin system in patients with panic disorder. Psychiatr Genetics 20:59-64.

48.  Jeon J, Dencker D, Wörtwein G, Woldbye DPD, Cui Y, Davis AA, Levey AI, Schütz G, Sager T, Mørk A, Li C, Deng C-X, Fink-Jensen A, Wess J (2010) A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neuroscience 30:2396-2405.

47.  Christiansen SH & Woldbye DPD (2010) Regulation of the galanin system by repeated electroconvulsive seizures in mice. J Neurosci Res 88:3635-43.

46.  Sørensen G, Wegener G, Hasselstrøm, J, Hansen, TvO, Woldbye DPD (2009) Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine. Neuroreport 20:1023-6.

45.  Petersen PS, Woldbye DPD, Madsen AN, Egerod KL, Jin C, Lang M, Rasmussen M, Beck-Sickinger AG, Holst B (2009) In vivo characterization of high basal signaling from the ghrelin receptor. Endocrinology 150:4920-30.

44.  Olling JD, Christensen DZ, Ulrichsen J, Woldbye DPD (2009) Complex plastic changes in the neuropeptide Y (NPY) system during ethanol intoxication and withdrawal in the rat brain. J Neurosci Res 87:2386-97.

43.  Koefoed P, vO Hansen T, Woldbye DPD, Werge T, Mors O, Hansen T, Jakobsen KD, Nordentoft M, Wang A, Bolwig TG, Rehfeld JF (2009) An intron 1 polymorphism in the CCK-A receptor gene associated with schizophrenia in males. Acta Psychiatr Scand 120:281-7.

42.  Thomsen M, Fink-Jensen A, Woldbye DPD, Wörtwein G, Sager TN, Holm R, Pepe LM, Barak Caine S (2008) Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats. Psychopharmacology 201:43-53.

41.  Sørensen S, Sager TN, Petersen JH, Brennum LT, Thøgersen P, Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DPD (2008) Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice. Psychopharmacology 199:37-46.

40.  Agasse F, Bernardino L, Kristiansen H, Christiansen SH, Ferreira R, Silva BA, Grade S, Woldbye DPD, Malva JO (2008) Neuropeptide Y promotes neurogenesis in murine subventricular zone. Stem Cells 26:1636-45.

39.  Thomsen M, Wörtwein G, Olesen MV, Begtrup M, Havez S, Bolwig TG, Woldbye DPD (2007) Involvement of Y5 receptors in neuropeptide Y agonist-induced analgesic-like effect in the rat hot plate test. Brain Res 1155:49-55.

38.  Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DPD, Wess J, Barak Caine S (2007) Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology 192:97-110.

37.  Silva AP, Lourenço J, Xapelli S, Ferreira R, Kristiansen H, Woldbye DPD, Oliveira CR, Malva JO (2007) Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus. FASEB J 21:671-81.

36.  Olling JD, Ulrichsen J, Haugbøl S, Glenthøj B, Hemmingsen R, Woldbye DPD (2007) Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats. Neurosci Lett 424:160-4.

35.  Hansen H, Rantamäki T, Larsen M, Woldbye DPD, Mikkelsen JD, Castrén E. (2007) Rapid activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway by electroconvulsive shock in the rat prefrontal cortex is not associated with TrkB neurotrophin receptor activation. Cellular Mol Neurobiol 27:585-94.

34.  Mikkelsen JD & Woldbye DPD (2006) Accumulated increase in neuropeptide Y and somatostatin gene expression in response to repeated electroconvulsive stimulation. J Psychiatric Res 40:153-9.

33.  Lindberg C, Koefoed P, Steno-Hansen E, Bolwig TG, Rehfeld JF, Mellerup E, Jørgensen OS, Kessing LV, Werge T, Haugbøl S, Wang AG, Woldbye DPD (2006) No association between the –399 C>T polymorphism of the neuropeptide Y gene and schizophrenia, major depression or panic disorder in a Danish population. Acta Psychiatrica Scand 113:54-8.

32.  Christensen DZ, Olesen MV, Kristiansen H, Mikkelsen JD, Woldbye DPD (2006) Unaltered neuropeptide Y (NPY) stimulated [35S]-GTPγS binding suggests a net increase in NPY signalling after chronic electroconvulsive seizures in mice. J Neurosci Res 84:1282-91.

31.  Woldbye DPD, Nanobashvili A, Sørensen AT, Husum H, Bolwig TG, Sørensen G, Ernfors P, Kokaia M (2005) Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. Neurobiol Disease 20:760-72.

30.  Thomsen M, Woldbye DPD, Wörtwein G, Fink-Jensen A, Wess J, Barak Caine S (2005) Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neuroscience 25:8141-9.

29.  Olesen OF, Bennike B, Steno-Hansen E, Koefoed P, Woldbye DPD, Bolwig TG, Mellerup E (2005) The short/long polymorphism in the serotonin transporter gene promoter is not associated with panic disorder in a Scandinavian sample. Psychiatric Genetics 15:159.

28.  Larsen MH, Olesen M, Woldbye DPD, Hay-Schmidt A, Hansen HH, Rønn LCB, Mikkelsen JD (2005) Regulation of activity-regulated cytoskeleton protein (Arc) mRNA after acute and chronic electroconvulsive stimulation in the rat. Brain Res 1064:161-5.

27.  Woldbye DPD & Kokaia M (2004) Neuropeptide Y and seizures: effects of exogenously applied ligands. Neuropeptides 38:253-60.

26.  Sørensen G, Wörtwein G, Bolwig TG, Woldbye DPD (2004) Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation. J Neurosci Res 77:723-9.

25.  Nanobashvili A, Woldbye DPD, Bolwig TG, Kokaia M (2004) Neuropeptide Y Y5 receptors suppress in vitro spontaneous epileptiform bursting in the rat hippocampus. Neuroreport 15:339-43.

24.  Fink-Jensen A, Fedorova I, Wörtwein G, Woldbye DPD, Rasmussen T, Thomsen M, Bolwig TG, Knitowski KM, McKinzie DL, Yamada M, Wess J, Basile A (2003) A role for M5 muscarinic acetylcholine receptors in cocaine addiction. J Neurosci Res 74:91-6.

23.  Woldbye DPD, Nanobashvili A, Husum H, Bolwig TG, Kokaia M (2002) Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice. Neurosci Lett 333:127-30.

22.  Woldbye DPD, Haugbøl S, Bolwig TG, Ulrichsen J (2002) Ethanol withdrawal in rats is attenuated by intracerebroventricular injection of neuropeptide Y. Alcohol & Alcoholism 37:318-21.

21.  Klemp K & Woldbye DPD (2001) Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dog shakes. Peptides 22:523-7.

20.  Karle J, Woldbye DPD, Diemer NH (2001) GABAAreceptor antisense epilepsy – histological changes following infusion of antisense oligodeoxynucleotide to GABAAreceptor g2 subunit into rat hippocampus. Neurol Res 23:39-46.

19.  Clausen TR, Møller M, Woldbye DPD (2001) Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brains regions. J Neurosci Res 64:410-7.

18.  Madsen TM, Woldbye DPD, Bolwig TG, Mikkelsen JD (1999) Kainic acid seizure suppression by neuropeptide Y is not correlated to immediate early gene mRNA levels in rats. Neurosci Lett 271:21-4.

17.  Bolwig TG, Woldbye DPD, Mikkelsen JD (1999) Electroconvulsive therapy as an anticonvulsant: a possible role of neuropeptide Y (NPY). J Electroconv Ther 15:93-101.

16.  Woldbye DPD & Larsen PJ (1998) The how and Y of eating. Nature Medicine 4:671-2.

15.  Woldbye DPD (1998) Antiepileptic effects of NPY on pentylenetetrazole seizures. Regul Peptides 75-76:279-82.

14.  Woldbye DPD, Klemp K, Madsen TM (1998) Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors. J Pharmacol Exp Therapeutics 284:633-6.

13.  Ulrichsen J, Woldbye DPD, Madsen TM, Clemmesen L, Haugbøl S, Olsen CH, Lauersen H, Bolwig TG, Hemmingsen R (1998) Electrical amygdala kindling is facilitated in alcohol-withdrawal kindled rats. Alcohol Alcoholism 33:244-54.

12.  Karle J, Woldbye DPD, Elster L, Diemer NH, Bolwig TG, Nielsen M (1998) Antisense oligonucleotide to GABAA receptor g2 subunit induces limbic status epilepticus. J Neurosci Res 54:863-9.

11.  Woldbye DPD, Larsen PJ, Mikkelsen JD, Klemp K, Madsen TM, Bolwig TG (1997) Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nature Medicine 3:761-4.

10.  Woldbye DPD, Madsen TM, Larsen PJ, Mikkelsen JD, Bolwig TG (1996) Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res 737:162-8.

9.    Woldbye DPD, Greisen MH, Bolwig TG, Larsen PJ, Mikkelsen JD (1996) Prolonged induction of c-fos in neuropeptide Y- and somatostatin-immunoreactive neurons of the rat dentate hilus after electroconvulsive stimulation. Brain Res 720:111-9.

8.    Woldbye DPD, Bolwig TG, Kragh J, Jørgensen OS (1996) Synaptic degeneration and remodelling after fast kindling of the olfactory bulb. Neurochem Res 21:583-91.

7.    Ulrichsen J, Woldbye DPD, Olsen CH, Haugbøl S, Madsen TM, Bolwig TG, Hemmingsen R (1996) No loss of somatostatin-immunoreactive neurons in the hippocampal dentate hilus of alcohol-withdrawal kindled rats. Alcohol Alcoholism 31:411-9.

6.    Dalby NO, Tønder N, Wolby D, West M, Finsen B, Bolwig TG (1996) No loss of hippocampal hilar somatostatinergic neurons after repeated electroconvulsive shock: a combined stereological and in situ hybridization study. Biol Psychiatry 40:54-60.

5.    Mikkelsen JD, Larsen PJ, Sørensen GG, Woldbye DPD, Bolwig TG, Hastings MH, Ebling FJP (1994) A dual immunocytochemical method to localize c-fos protein in specific neurons based on their content of neuropeptides and connectivity. Histochemistry 101:245-51.

4.    Mikkelsen JD, Woldbye DPD, Kragh J, Larsen PJ, Bolwig TG (1994) Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus. Mol Brain Res 23:317-22.

3.    Kragh J, Bruhn T, Woldbye DPD, Bolwig TG (1993) Electroconvulsive shock (ECS) does not facilitate the development of kindling. Prog Neuropsychopharm Biol Psychiatry 17:985-9.

2.    Kragh J, Woldbye DPD, Bolwig TG (1993) Long-term effects of repeated electroconvulsive shock on exploratory behaviour and seizure susceptibility to lidocaine in rats. J Psychiat Res 27:89-94.

1.    Kragh J, Bolwig TG, Woldbye DPD, Jørgensen OS (1993) Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein (GFAP). Biol Psychiatry 33:794-800.



Woldbye DPD (2002) “Neuropeptide Y” in The Encyclopedia of Molecular Medicine.


US 08901094; PCT/SE2007/050494

Inventors: Merab Kokaia & David Woldbye. Use of nucleic acid sequences for the treatment of neurological and psychiatric diseases, vectors and compositions. Patent acquired in USA and EU.

WO2009112033-A1; EP2280703-A1; US2011060037-A1; PCT/DK2009/050052

Inventors: David P.D. Woldbye & Gunnar Sørensen. Use of a neuropeptide Y receptor Y5 antagonist for the preparation of a medicament for achieving a reduction in and/or prevention of abuse of psychostimulants and/or opioids e.g. cocaine or heroin, in an individual.

US 2016/0060320 A1; Priority Application P3184DK00; PCT WO2014166497-A2 April 2014

Inventors: David P.D. Woldbye, Casper Gøtzsche, Kristian Klemp, Vladimir Berezin, Elisabeth Bock. Neuropeptide Y-Derived Peptides for Induction of Neuroplastic Effects. New peptide useful for treating disease or disorder of central nervous system.