Publication List – University of Copenhagen

C. J. Loland - List of Publications

Total number of accepted peer reviewed papers: 64
-       of which are reviews: 4
Patent applications: 1
Book chapters: 4

Number of citations >2100, H-index: 23 (Source: Scopus)


1.    P.S. Merkle, K. Gotfryd, M.A. Cuendet, K. Leth-Espersen, U. Gether, C.J. Loland, K.D. Rand. “Hydrogen-deuterium exchange reveals local unfolding events related to function in the neurotransmitter:sodium symporter homolog LeuT”. Science Advances, In Press (IF: No IF yet)

2.    P.S. Chae, M. Ehsan, M. Das, V. Stern, Y. Du, J. Mortensen, P. Hariharan, B. Byrne, C.J. Loland, B.K. Kobilka, L. Guan. “Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability”. ChemBioChem (2018) doi: 10.1002/cbic.201800106 (IF: 2.85)

3.    A. Sadaf, Y. Du, C. Santillan, J.S. Mortensen, I. Molist, A.B.Seven, P. Hariharan, G. Skiniotis, C.J. Loland, B.K. Kobilka, L. Guan, B. Byrne, P.S. Chae. “Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study”. Chemical Science (2018), 8(12): 2489-2498 (IF: 9.14)

4.    M. Ehsan, Y. Du, I. Molist, A.B. Seven, P. Hariharan, J.S. Mortensen, L. Ghani, C.J. Loland, G. Skiniotis, L. Guan, B. Byrne, B.K. Kobilka, P.S. Chae. “Vitamin E-based glycoside amphiphiles for membrane protein structural studies”. Organic & Biomolecular Chemistry, (2018) 16(14):2489-2498 (IF: 3.56)

5.    F. Herborg, T.F. Andreassen, F. Berlin, C.J. Loland, U. Gether. “Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes”. Journal of Biological Chemistry (2018), doi: 10.1074/jbc.RA118.001753 (IF: 4.13)


6.    M-F. Zou, J. Cao, A. Abramyan, T. Kopajtic, C. Zanettini, D. Guthrie, R. Rais, B.  Slusher, L. Shi, C.J. Loland, A.H. Newman. “Structure-activity relationship studies on a series of 3α-[bis(4-fluorophenyl)methoxy]tropanes and 3α-[bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (DAT) inhibitors for the treatment of cocaine use disorders”. Journal of Medicinal Chemistry (2017) 60(24):10172-10691 (IF: 6.26)

7.    S. Erlendsson, K. Gotfryd, F.H. Larsen, J.S. Mortensen, M-A. Geiger, B-J van Rossum, H. Oschkinat, U. Gether, K. Teilum, C.J. Loland. “Direct Assessment of Substrate Binding to the Neurotransmitter:Sodium Symporter LeuT by Solid State NMR”. eLife (2017), doi: 10.7554/eLife.19314 (IF: 8.30)

8.    M. Ehsan, L. Ghani, Y. Du, P. Hariharan, J.S. Mortensen, O. Ribeiro, G. Skiniotis, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae. “New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies”. Analyst (2017) doi: 10.1039/c7an01168g (IF: 3.89)

9.    H. Hussain, J.S. Mortensen, Y. Du, C. Santillan, O. Ribeiro, J. Go, P. Hariharan, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae. “Tandem malonate-based glucosides (TMGs) for membrane protein structural studies”. Science Reports (2017) 7(1):3963. doi: 10.1038/ s41598-017-03809-3. (IF: 4.26)

10. M. Das, Y. Du, J.S. Mortensen, O. Ribeiro, P. Hariharan, L. Guan, C.J. Loland, B.K. Kobilka, B. Byrne, P.S. Chae. “Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region”. Chemical Science (2017) 8(2):1169-1177. doi: 10.1039/c6sc02981g (IF: 9.14)

11. A.M. Abramyan, S. Stolzenberg, Z. Li, C.J. Loland, F. Noé, L. Shi. “The isomeric preference of an atypical dopamine transporter inhibitor contributes to its selection of the transporter conformation”. ACS Chemical Neuroscience (2017) doi: 10.1021/acschemneuro.7b00094 (IF: 4.35)

12. H. Hussain, Y. Du, E. Tikhonova, J.S. Mortensen, O. Ribeiro, C. Santillan, M. Das, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae. “Resorcinarene-based facial glycosides: implication of detergent flexibility on membrane protein stability”. Chemistry – A European Journal (2017) doi:10.1002/chem.201605016 (IF: 5.29)

13. M. Das, Y. Du, O. Ribeiro, P. Hariharan, J. Mortensen, D. Patra, G. Skiniotis, C.J.  Loland, L. Guan, B. Kobilka, B. Byrne, P.S. Chae. ”Conformationally preorganized diastereomeric norbornane-based maltosides (NBMs) for membrane protein study: Implications of detergent kink for micellar properties”. Journal of the American Chemical Society (2017) doi:10.1021/jacs.6b11997 (IF: 13.0)

14. S. Topiol, B. Bang-Andersen, C. Sanchez, P. Plenge, C.J. Loland, K. Juhl, K. Larsen, P. Bregnedal, K.P. Bøgesø. “X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT”. Bioorganic & Medicinal Chemistry Letters (2017), 27(3):470-478 (IF: 2.49)


15. C.B. Billesbølle, J.S. Mortensen, A. Sohail, S.G. Schmidt, L. Shi, H.H. Sitte, U. Gether, C.J. Loland. “Transition metal ion FRET uncovers K+ regulation of a neurotransmitter:sodium symporter”. Nature Communication, DOI: 10.1038/NCOMMS12755. (IF: 11.3)

16. K.H. Cho, P. Hariharan, J.S. Mortensen, Y. Du, A.K. Nielsen, B. Byrne, B.K. Kobilka, C.J. Loland, L. Guan, P.S. Chae. “Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length”. ChemBioChem (2016) 17(24): 2334-2339 (IF: 2.85)

17. J. Cao, R.D. Slack, O.M. Bakare, C. Burzynski, R. Rais, B.S. Slusher, T. Kopajtic, A. Bonifazi, M.P. Ellenberger, H. Yano, Y. He, G.H. Bi, Z.X. Xi, C.J. Loland, A.H. Newman. “Novel and high affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) analogues as atypical dopamine transporter inhibitors”. Journal of Medicinal Chemistry (2016), 59(23):10676-10691. (IF: 5.59)

18. A. Sohail, K. Jayaraman, S. Venkatesan, K. Gotfryd, M. Daerr, U. Gether, C.J. Loland, K.T. Wanner, M. Freissmuth, H.H. Sitte, W. Sandtner, T. Stockner. “The environment shapes the inner vestibule of LeuT”. PLoS Computational Biology (2016), 12(11):e1005197. doi: 10.1371 (IF: 4.59)

19. K.H. Cho, O. Ribeiro, Y. Du, E. Tikhonova, J.S. Mortensen, K. Markham, P. Hariharan, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae. “Mesitylene-cored glucoside amphiphiles (MGAs) for membrane protein studies:  importance of alkyl chain density in detergent efficacy”. Chemistry – A European Journal (2016), 10.1002/chem.201603338 (IF: 5.29)

20. H.E. Bae, J.S. Mortensen, O. Ribeiro, Y. Du, M. Esan, B.K. Kobilka, C.J. Loland, B. Byrne, P.S. Chae. “Tandem Neopentyl Glycol Maltosides (TNMs) for Membrane Protein Stabilisation”. Chemical Communications (2016), 52(84):12104-12107 (IF: 6.57)

21. C.J. Loland, C. Sanchez, P. Plenge, K.P. Bøgesø, B. Bang-Andersen. “Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target”. In ‘Allosterism in Drug Discovery’ Royal Society of Chemistry, Drug Discovery Series no. 65 (ed. D. Doller), (2017) page 360-380. doi: 10.1039/9781782629276

22. G. Khelashvili, S.G. Schmidt, L. Shi, J.A. Javitch, U. Gether, C.J. Loland, H. Weinstein. “Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290”. Journal of Biological Chemistry (2016), 291(38):19786-99 (IF: 4.26)

23. M. Ehsan, Y. Du, N.J. Scull, E. Tikhonova, J. Tarrasch, J.S. Mortensen, C.J. Loland, G. Skiniotis, L. Guan, B. Byrne, B.K. Kobilka, P.S. Chae. “Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies”. Journal of American Chemical Society (2016), 138(11): 3789-3796 (IF: 13.0)

24. A. Sadaf, J.S. Mortensen, S. Capaldi, E. Tikhonova, P. Hariharan, O. de Castro Ribeiro, C.J. Loland, L. Guan, B. Byrne, P.S. Chae. “A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study”. Chemical Science (2016), 7(3): 1933-1939 (IF: 9.14)

25. H. Hussain, Y. Du, N.J. Scull, J. S. Mortensen, J. Tarrasch, H.E. Bae, C.J. Loland, B. Byrne, B.K. Kobilka, P.S. Chae. “Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation”. ChemistryA European Journal (2016), 22(21): 7068-7073 (IF: 5.29)

26. M.A.B. Larsen, P. Plenge, J. Andersen, J.N.N. Eildal, A.S. Kristensen, K.P. Bøgesø, U. Gether, K. Strømgaard, B. Bang-Andersen, C.J. Loland. “Structure-activity relationship studies of citalopram derivatives: Examining substituents conferring selectivity for the allosteric site in the serotonin transporter”. British Journal of Pharmacology (2016), 173(5):925-36 (IF: 5.26)


27. C.B. Billesbølle, M.B. Krüger, L. Shi, M. Quick, Z. Li, S. Stolzenberg, J. Kniazeff, K. Gotfryd, J.A. Javitch, H. Weinstein, C.J. Loland, U. Gether. “Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter”. Journal of Biological Chemistry (2015), 290(44): 26725-26738 (IF: 4.26)

28. C.J. Loland and U. Gether. “Neurotransmitter Transporters: Structure, Function and Drug Binding”. in ‘Textbook of Drug Design and Discovery’, 5th edition (ed. U. Madsen), Taylor & Francis Group, LLC, 2015.  

29. V. Jagalski, R. Barker, M.B. Thygesen, K. Gotfryd, M. Krüger, L. Shi, S. Maric, N. Bovet, M. Moulin, M. Haertlein, T. Günther Pomorski, C.J. Loland, M. Cardenas. “Grafted Biomembranes Containing Membrane Proteins - The Case for the Leucine Transporter”. Soft Matter (2015), 11(39): 7707-7711 (IF: 3.80) 

30. K.H. Cho, Y. Du, N.J. Scull, P Hariharan. K. Gotfryd, C.J. Loland ,L. Guan, B. Byrne, B.K Kobilka, P.S. Chae. “Novel Xylene-linked Maltose Amphipiles (XMAs) for Membrane Protein Stabilisation”. Chemistry – A European Journal (2015), 21(28): 10008-10013 (IF: 5.29)

31. H.E. Bae, K. Gotfryd, J. Thomas, H. Hussain, M. Ehsan, J. Go, C.J. Loland ,B. Byrne, P.S. Chae. “Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation”. ChemBioChem – Communications (2015), 16(10): 1454-1459 (IF: 2.85)

32. S. Stolzenberg, M. Quick, C. Zhao, K. Gotfryd, G. Khelashvili, U. Gether, C.J. Loland, J.A. Javitch, S. Noskov, H. Weinstein, L. Shi. “Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters”. Journal of Biological Chemistry (2015), 290(22): 13992-4003 (IF: 4.26)

33. K.H. Cho, M. Husri, A. Amin, K. Gotfryd, H.J. Lee, J. Go, J.W. Kim, C.J. Loland ,L. Guan, B. Byrne, P.S. Chae. “Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study”. Analyst (2015), 140(9): 3157-3163 (IF: 4.03)

34. C.J. Loland. “The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters”. Biochimica Biophysica Acta – General Subjects (2015), 1850(3): 500-510 (IF: 3.66)


35. F.H. Hansen, T. Skjørringe, S. Yasmeen, N. Arends, M.A. Sahai, K. Erreger, T.F. Andreassen, M. Holy, P.J. Hamilton, V. Neergheen, M. Karlsborg, A.H. Newman, S. Pope, S.JR. Heales, L. Friberg, I. Law, L.H. Pinborg, H.H. Sitte, C. J. Loland, L. Shi, H. Weinstein, A. Galli, L.E. Hjermind, L.B. Møller, U. Gether. “Missense Mutations in the Dopamine Transporter Gene Associated with Adult Parkinsonism and ADHD”. Journal of Clinical Investigation (2014), 124(7): 3107-3120 (IF: 13.2)

36. A.V. Pedersen, T.F. Andreassen, C.J. Loland. “A Conserved Salt Bridge between Transmembrane Segment 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter”. Journal of Biological Chemistry (2014), 289(50): 35003-350014 (IF: 4.57)

37. O.M Okunola-Bakare, J. Cao, T. Kopajtic, J.L. Katz, C.J. Loland, L. Shi, A.H. Newman. “Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues”. Journal of Medicinal Chemistry (2014), 57(3): 1000-1003 (IF: 5.45)


38. A.K. Banala, P. Zhang, P. Plenge, G. Cyriac, T. Kopajtic, J.L. Katz, C.J. Loland, A.H. Newman. “Design and Synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites”. Journal of Medicinal Chemistry (2013), 56(23): 9709-9724 (IF: 5.48)

39. P.S. Chae, A.C. Kruse, K. Gotfryd, R.R. Rana, K.H. Cho, S.G. Rasmussen, H.E. Bae R., Chandra, U. Gether, L. Guan, B.K. Kobilka, C.J. Loland, B. Byrne, S.H. Gellman. “Novel Tripod Amphiphiles for Membrane Protein Analysis”. Chemistry – a European Journal (2013), 56(23): 15645-15651 (IF: 5.70)

40. P.S. Chae, R.R. Rana, K. Gotfryd, S.G.F. Rasmussen, A.C. Kruse, K.H Cho, S. Capaldi, B. Kobilka, C.J. Loland, U. Gether, S. Banerjee, B. Byrne, J.K. Lee,  S.H. Gellman. “Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Study”. Chemical Communications (2013), 49(23):2287-2289 (IF: 6.72)

41. P. Zhang, T.N. Jørgensen, C.J. Loland, A.H. Newman. “A Rhodamine-Labeled Citalopram Analogue as a High-Affinity Fluorescent Probe for the Serotonin Transporter”. Bioorganic & Medicinal Chemistry Letters (2013), 23(1):323-326 (IF: 2.33)

42. K.J. Simmons, K. Gotfryd, C.B. Billesbølle, C.J. Loland, U. Gether, C.W. Fishwick, A.P. Johnson. “A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT”. Molecular Membrane Biology (2013), 30(2):184-194 (IF: 1.73)


43. P. Plenge, L. Shi, T. Beuming, A.H. Newman, H. Weinstein, U. Gether, C.J. Loland. “Steric Hindrance mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter”. Journal of Biological Chemistry (2012), 287(47):39316-39326 (IF: 4.65)

44. C.J. Loland, M. Mereu, O. M. Okunola, J. Cao, T. E. Prisinzano, T. Kopajtic,  L. Shi,  J. L. Katz, G. Tanda,  A. H. Newman. “R-Modafinil (Armodafinil): A unique dopamine uptake inhibitor and potential medication for psychostimulant abuse”. Biological Psychiatry (2012), 72(5):405-413 (IF: 9.25)


45. P.S Chae, S.G. Rasmussen, R.R. Rana, K. Gotfryd, A.C. Kruse, A. Manglik, K.H. Cho, S. Nurva, U. Gether, L. Guan, C.J. Loland, B. Byrne, B.K. Kobilka, S.H. Gellman. “A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins”. Chemistry (2012), 18(31):9485-9490 (IF: 5.83)

46. G. Sørensen, M. Weikop, D. Dencker, C.J. Loland, C. H. Bengtsen, J. H. Petersen, A. Fink-Jensen, G. Wörtwein, D. P. Woldbye. “Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice”. Psychopharmacology (Berl) (2012), 222(4):565-577 (IF: 4.06)


47. A.S. Kristensen, J. Andersen, T.N. Jørgensen, L. Sørensen, J. Eriksen, C.J. Loland, K. Strømgaard, U. Gether. “The SLC6 neurotransmitter transporters: structure, function and regulation”. Pharmacological Reviews (2011), 63(3):585-640 (IF: 20.2)

48. H. Bisgaard, M.A. Larsen, S. Mazier, T. Beuming, A.H. Newman, H. Weinstein, L. Shi, C.J. Loland, U. Gether. “The binding sites for benztropines and dopamine in the dopamine transporter overlap”. Neuropharmacology (2011), 60(1):182-190 (IF: 4.81)


49. P.S. Chae, S.G. Rasmussen, R.R. Rana, K. Gotfryd, R. Chandra, M.A. Goren, A.C. Kruse, S. Nurva, C.J. Loland, Y. Pierre, D. Drew, J.L. Popot, D. Picot, B.G. Fox, L. Guan, U. Gether, B. Byrne, B. Kobilka, S.H. Gellman. “Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins”. Nature Methods (2010), 7(12):1003-1008 (IF: 20.7) 

50. P.S. Chae,  K. Gotfryd, J. Pacyna, L.J. Miercke, S.G. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B Byrne, U Gether, S.H. Gellman. “Tandem Facial Amphiphiles for Membrane Protein Stabilization”. Journal of American Chemical Society (2010), 132(47):16750-16752 (IF: 9.02)

51. C.J. Loland and U. Gether. “Neurotransmitter Transporters: Structure and Function”. in ‘Textbook of Drug Design and Discovery’, 4th edition (ed.. U. Madsen), Taylor & Francis Group, LLC, 2010 


52. T. Beuming, J. Kniazeff; M.L. Bergmann, L. Shi, L. Gracia, K. Raniszewska, A.H. Newman, J.A. Javitch, H. Weinstein, U. Gether, and C.J. Loland. “The Binding Sites for Cocaine and Dopamine in the Dopamine Transporter are Overlapping”. Nature Neuroscience (2008), 11(7): 780-789 (IF: 14.2)

53. J. Kniazeff, L. Shi, C.J. Loland, H. Weinstein, and U. Gether. “An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter”. Journal of Biological Chemistry (2008), 283(25): 17691-17701 (IF: 5.52) 

54. C.J. Loland, R.I. Desai, M.-F. Zou, J. Cao, P. Grundt, K. Gerstbrein, H.H. Sitte, A.H. Newman, J.L. Katz, and U. Gether. “Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors”. Molecular Pharmacology (2008), 73: 813-823 (IF: 4.71)


55. K.M. Kahlig, B.J. Lute, Y. Wei, C.J. Loland, U. Gether, J.A. Javitch, A. Galli. “Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine”. Molecular Pharmacology (2006), 70(2):542-548 (IF: 4.47)


56. J.H. Cha, M.-F. Zou, E.M. Adkins, S.G.F. Rasmussen,  C.J. Loland, B. Shonenberger, U. Gether, and A.H. Newman. “Rhodamine-labeled 2β-carbomethoxy-3β-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter”. Journal of Medicinal Chemistry (2005), 48(24): 7513-7516 (IF: 4.97)

57. J. Kniazeff, C.J. Loland, N. Goldberg, M. Quick, S. Das, H.H. Sitte, J.A. Javitch, and U. Gether. “Intramolecular Cross-Linking in a Bacterial Homolog of Mammalian SLC6 Neurotransmitter Transporters Suggests an Evolutionary Conserved Role of Transmembrane Segments 7 and 8”. Neuropharmacology (2005), 49(6): 7024-7036 (IF: 3.84)


58. C. Bjerggaard, J. Fog, H. Hastrup, K. Madsen, C.J. Loland, J. Javitch, and U. Gether. “Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus but does not Require Canonical PDZ Domain Interactions”. Journal of Neuroscience (2004), 24(31): 7024-7036 (IF: 8.02)

59. C.J. Loland, C. Grånäs, J.A. Javitch, and U. Gether. “Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding”. Journal of Biological Chemistry (2004), 279(5): 3228-3238 (IF: 6.57)

60. C.J. Loland, and U. Gether. “Insights from Endogenous and Engineered Zn2+-binding Sites in Monoamine Transporters”. In Molecular Neuropharmacology: Strategies and Methods (Schousboe, A. and Bräuner-Osborne, H., ed.) Humana Press, Totowa, New Jersey (2004), 191-213


61. C.J. Loland, K. Norgaard-Nielsen, and U. Gether. “Probing Dopamine Transporter Structure and Function by Zn2+-site Engineering”. European Journal of Pharmacology (2003), 479(1-3): 187-197 (IF: 2.35)

62. L. Norregaard, C.J. Loland, and U. Gether. “Evidence for distinct sodium, dopamine and cocaine dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter”. Journal of Biological Chemistry (2003), 278(33): 30587-30596 (IF: 6.41)

63. C. Grånäs, J. Ferrer, C.J. Loland, J.A. Javitch and U. Gether. “N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester and Substance P Receptor Stimulated Phosphorylation Without Impairing Transporter Internalization”. Journal of Biological Chemistry (2003), 278(7): 4990-5000 (IF: 6.41)


64. C.J. Loland, L. Norregaard, T. Litman and U. Gether. “Generation of an Activating Zn2+ Switch in the Dopamine Transporter: Mutation of an Intracellular Tyrosine Constitutively Alters the Conformational Equilibrium of the Transport Cycle”. Proceedings of the National Academy of Sciences USA (2002), 99(3): 1683-1688 (IF: 10.7)


65. N. MacAulay, A. Bendahan, C.J. Loland, T. Zeuthen, B. Kanner and U. Gether. “Engineered Zn2+ Switches in the GABA Transporter-1: Differential Effects on GABA Uptake and Currents”. Journal of Biological Chemistry (2001), 276(44): 40476-40485 (IF: 6.61)

66. U. Gether, L. Norregaard and C.J. Loland. “Delineating Structure-Function Relationships in the Dopamine Transporter from Natural and Engineered Zn2+ Binding Sites”. Life Sciences (2001), 68(19-20):2187-2198 (IF: 1.79)


67. L. Norregaard, I. Visiers, C.J. Loland, J. Ballasteros, H. Weinstein and U. Gether “Structural Probing of a Microdomain in the Dopamine Transporter by Engineering of Artificial Zn2+ Binding Sites”. Biochemistry (2000), 39(51): 15836-15846


68. C.J. Loland, L. Norregaard, and U. Gether. “Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter. Identification of a Conserved Glutamic Acid as a Third Coordinate in the Endogenous Zn2+ Binding site”. Journal of Biological Chemistry. (1999), 274(52): 36928-36934 (IF: 7.67)

Patent applications

“Use of dihydro-isobenzofuran in combination with serotonin reuptake inhibitors for CNS disease e.g. depression, anxiety, bipolar disorder, obsessive compulsory disorder”
Inventors: K.P. Bogeso, K. Juhl, H. Zhong, C.J. Loland
Patent Number: WO2013110313-A1
Patent Assignee Name and Code: LUNDBECK AS H(LUND-C)
Derwent Primary Accession Number: 2013-M11364 [55]