C. J. Loland - List of Publications

Total number of accepted peer reviewed papers: 79
- of which are reviews: 4
Patent applications: 1
Book chapters/Special editor: 6
Number of citations >2800, H-index: 27 (Source: Scopus),
#shared correspondence; IF: Journal impact factor at the year of publication

I. Peer reviewed Publications

I.I Articles

1. P. Plenge, A.M. Abramyan, G. Sørensen, A. Mørk, P. Weikop, U. Gether, #B. Bang-Andersen, #L. Shi, #C.J. Loland
“The mechanism of a novel high-affinity allosteric inhibitor of the serotonin transporter”
Nature Communications (2020) 11:1491. doi: 10.1038/s41467-020-15292-y
(IF: 11.88)

2. K. Gotfryd, T. Boesen, J.S. Mortensen, G. Khelashvili, M. Quick, D.S. Terry, J.W. Missel, M.V. LeVine, P. Gourdon, S.C. Blanchard, J.A. Javitch, H. Weinstein, #C.J. Loland, #P. Nissen, #U. Gether
“Mechanism of substrate release in neurotransmitter:sodium symporters: the structure of LeuT in an inward-facing occluded conformation”
Nature Communications, (2020) 11(1):1005. doi: 10.1038/s41467-020-14735-w.
(IF: 11.88)


3. L. Ghani, C.F. Munk, X. Zhang, S. Katsube, Y. Du, C. Cecchetti, W. Huang, H.E. Bae, S. Saouros, M. Ehsan, L. Guan, X. Liu, C.J. Loland, B.K. Kobilka, B. Byrne, P.S. Chae.
“1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization”
Journal of the American Chemical Society (2019). doi: 10.1021/jacs.9b07883. (IF: 14.70)

4. R.D. Slack, T.C. Ku, J. Cao, J.B. Giancola, A. Bonifazi, C.J. Loland, A. Gadiano, J. Lam, R. Rais, B.S. Slusher, M. Coggiano , G. Tanda, A.H. Newman.
“Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability”
Journal of Medicinal Chemistry (2019). doi: 10.1021/acs.jmedchem.9b01188 (IF: 6.05)

5. A.K. Nielsen, I.R. Möller, Y. Wang, S.G.F. Rasmussen, K. Lindorff-Larsen, #K. Rand, #C.J. Loland
”Substrate-Induced Conformational Dynamics of the Dopamine Transporter”
Nature Communications (2019), 10(1): 2714, doi: 10.1038/s41467-019-10449-w (IF: 12.35)

6. I.R. Möller, M. Silvacka, A.K. Nielsen, S.G.F. Rasmussen, U. Gether, #C.J. Loland, #K. Rand
“Conformational Dynamics of the Human Serotonin Transporter during Substrate and Drug Binding”
Nature Communications (2019), 10(1):1687. doi: 10.1038/s41467-019-09675-z (IF: 12.35)

7. I.R. Möller, M. Silvacka, J. Hausner A.K. Nielsen, S.G.F. Pospíšilová E, Merkle PS, Lišková R, Polák M, Loland CJ, Kádek A, Man P, Rand KD.
“Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments”
Analytical Chemistry (2019), 91(17):10970-10978. doi: 10.1021/acs.analchem.9b00973 (IF: 6.35)

8. A. Sadaf, M. Ramos, J.S. Mortensen, Y. Du, H.E. Bae, C.F. Munk, P. Hariharan, B. Byrne, B.K. Kobilka, C.J. Loland, L. Guan, P:S. Chae
“Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability”
ACS Chemical Biology (2019), 14(8):1717-1726. doi: 10.1021/acschembio.9b00166 (IF: 4.37)

9. M. Ehsan, Y. Du, J.S. Mortensen, P. Hariharan, Q. Qu, L. Ghani, M. Das, A. Grethen, B. Byrne, G. Skiniotis, S. Keller, C.J. Loland, L. Guan, B.K. Kobilka, P.S. Chae.
“Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability”
Chemistry – A European Journal (2019), 25(49): 11545-11554. 10.1002/chem.201902468 (IF: 5.16)

10. M. Ehsan, A. Kumar, J.S. Mortensen, Y. Du, P. Hariharan, K.K Kumar, B. Ha, B. Byrne, L. Guan, B.K. Kobilka, C.J. Loland, P.S. Chae
“Self-assembly behaviors of a penta-phenylene maltoside and its application for membrane protein study”
Chemistry – An Asian Journal (2019), doi: 10.1002/asia.201900224 (IF: 3.69)

11. M. Das, Y. Du, J.S. Mortensen, M. Ramos, L. Ghani, H.J. Lee, H.E. Bae, B. Byrne, L. Guan, C.J. Loland, B.K. Kobilka, P.S. Chae
“Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability”
Organic & Biomolecular Chemistry (2019), 17(12): 1107-1116, doi: 10.1039/c8ob03153c. (IF: 3.49)


12. H.E. Bae, Y. Du, P. Hariharan, J.S. Mortensen, K.K. Kumar, B. Ha, M. Das, H.S. Lee, C.J. Loland, L. Guan, B.K. Kobilka, P.S. Chae
“Asymmetric maltose neopentyl glycol amphiphiles for membrane protein study: Effect of detergent asymmetricity on protein stability”
Chemical Science (2018), 10(4): 1107-1116. doi: 10.1039/c8sc02560f (IF: 9.06)

13. P.S. Merkle, K. Gotfryd, M.A. Cuendet, K. Leth-Espersen, U. Gether, C.J. Loland, K.D. Rand
“Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT”
Science Advances (2018), 4(5):eaar6179, doi: 10.1126/sciadv.aar6179 (IF: 11.51)

14. H. Hussain, T. Helton, Y. Du, J.S. Mortensen, P. Hariharan, M. Ehsan, B. Byrne, C.J. Loland, B.K. Kobilka, L. Guan, P.S. Chae.
“A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability”
Analyst (2018) 143(23):5702-5710 doi: 10.1039/c8an01408f (IF: 3.86)

15. M. Das, Y. Du, J.S. Mortensen, P. Hariharan, H.S. Lee, B. Byrne, C.J. Loland, L. Guan, B.K. Kobilka, P.S. Chae,
“Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy”
ChemBioChem (2018) doi: 10.1002/cbic.201800388 (IF: 2.69)

16. M. Das, Y. Du, J.S. Mortensen, H.E. Bae, B. Byrne, C.J. Loland, B.K. Kobilka, P.S. Chae
“An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability”
Chemistry – A European Journal (2018) doi: 10.1002/chem.201801141 (IF: 5.32)

17. P.S. Chae, M. Ehsan, M. Das, V. Stern, Y. Du, J.S. Mortensen, P. Hariharan, B. Byrne, C.J. Loland, B.K. Kobilka, L. Guan
“Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability”
ChemBioChem (2018) doi: 10.1002/cbic.201800106 (IF: 2.85)

18. A. Sadaf, Y. Du, C. Santillan, J.S. Mortensen, I. Molist, A.B.Seven, P. Hariharan, G. Skiniotis, C.J. Loland, B.K. Kobilka, L. Guan, B. Byrne, P.S. Chae
“Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study”
Chemical Science (2018), 8(12): 2489-2498 (IF: 9.14)

19. M. Ehsan, Y. Du, I. Molist, A.B. Seven, P. Hariharan, J.S. Mortensen, L. Ghani, C.J. Loland, G. Skiniotis, L. Guan, B. Byrne, B.K. Kobilka, P.S. Chae
“Vitamin E-based glycoside amphiphiles for membrane protein structural studies.”
Organic & Biomolecular Chemistry, (2018) 16(14):2489-2498 (IF: 3.56)

20. F. Herborg, T.F. Andreassen, F. Berlin, C.J. Loland, U. Gether
“Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes”
Journal of Biological Chemistry (2018), doi: 10.1074/jbc.RA118.001753 (IF: 4.13)


21. M-F. Zou, J. Cao, A. Abramyan, T. Kopajtic, C. Zanettini, D. Guthrie, R. Rais, B. Slusher, L. Shi, C.J. Loland, A.H. Newman
“Structure-activity relationship studies on a series of 3α-[bis(4-fluorophenyl)methoxy]tropanes and 3α-[bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (DAT) inhibitors for the treatment of cocaine use disorders”
Journal of Medicinal Chemistry (2017) 60(24):10172-10691 (IF: 6.26)

22. S. Erlendsson, K. Gotfryd, F.H. Larsen, J.S. Mortensen, M-A. Geiger, B-J van Rossum, H. Oschkinat, U. Gether, #K. Teilum, #C.J. Loland
“Direct Assessment of Substrate Binding to the Neurotransmitter:Sodium Symporter LeuT by Solid State NMR”
eLife (2017), doi: 10.7554/eLife.19314 (IF: 8.30)

23. M. Ehsan, L. Ghani, Y. Du, P. Hariharan, J.S. Mortensen, O. Ribeiro, G. Skiniotis, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae
“New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies”
Analyst (2017) doi: 10.1039/c7an01168g (IF: 3.89)

24. H. Hussain, J.S. Mortensen, Y. Du, C. Santillan, O. Ribeiro, J. Go, P. Hariharan, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae
“Tandem malonate-based glucosides (TMGs) for membrane protein structural studies”
Science Reports (2017) 7(1):3963. doi: 10.1038/ s41598-017-03809-3. (IF: 4.26)

25. M. Das, Y. Du, J.S. Mortensen, O. Ribeiro, P. Hariharan, L. Guan, C.J. Loland, B.K. Kobilka, B. Byrne, P.S. Chae
“Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region”
Chemical Science (2017) 8(2):1169-1177. doi: 10.1039/c6sc02981g (IF: 9.14)

26. A.M. Abramyan, S. Stolzenberg, Z. Li, C.J. Loland, F. Noé, L. Shi
“The isomeric preference of an atypical dopamine transporter inhibitor contributes to its selection of the transporter conformation”
ACS Chemical Neuroscience (2017) doi: 10.1021/acschemneuro.7b00094 (IF: 4.35)

27. H. Hussain, Y. Du, E. Tikhonova, J.S. Mortensen, O. Ribeiro, C. Santillan, M. Das, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae
“Resorcinarene-based facial glycosides: implication of detergent flexibility on membrane protein stability”
Chemistry – A European Journal (2017) doi:10.1002/chem.201605016 (IF: 5.29)

28. M. Das, Y. Du, O. Ribeiro, P. Hariharan, J. Mortensen, D. Patra, G. Skiniotis, C.J. Loland, L. Guan, B. Kobilka, B. Byrne, P.S. Chae
”Conformationally preorganized diastereomeric norbornane-based maltosides (NBMs) for membrane protein study: Implications of detergent kink for micellar properties”
Journal of the American Chemical Society (2017) doi:10.1021/jacs.6b11997 (IF: 13.0)

29. S. Topiol, B. Bang-Andersen, C. Sanchez, P. Plenge, C.J. Loland, K. Juhl, K. Larsen, P. Bregnedal, K.P. Bøgesø
“X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT”
Bioorganic & Medicinal Chemistry Letters (2017), 27(3):470-478 (IF: 2.49)


30. C.B. Billesbølle, J.S. Mortensen, A. Sohail, S.G. Schmidt, L. Shi, H.H. Sitte, U. Gether, C.J. Loland
“Transition metal ion FRET uncovers K+ regulation of a neurotransmitter:sodium symporter”
Nature Communications, DOI: 10.1038/NCOMMS12755. (IF: 11.3)

31. K.H. Cho, P. Hariharan, J.S. Mortensen, Y. Du, A.K. Nielsen, B. Byrne, B.K. Kobilka, C.J. Loland, L. Guan, P.S. Chae.
“Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length”
ChemBioChem (2016) 17(24): 2334-2339 (IF: 2.85)

32. J. Cao, R.D. Slack, O.M. Bakare, C. Burzynski, R. Rais, B.S. Slusher, T. Kopajtic, A. Bonifazi, M.P. Ellenberger, H. Yano, Y. He, G.H. Bi, Z.X. Xi, C.J. Loland, A.H. Newman.
“Novel and high affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) analogues as atypical dopamine transporter inhibitors”
Journal of Medicinal Chemistry (2016), 59(23):10676-10691. (IF: 5.59)

33. A. Sohail, K. Jayaraman, S. Venkatesan, K. Gotfryd, M. Daerr, U. Gether, C.J. Loland, K.T. Wanner, M. Freissmuth, H.H. Sitte, W. Sandtner, T. Stockner
“The environment shapes the inner vestibule of LeuT”
PLoS Computational Biology (2016), 12(11):e1005197. doi: 10.1371 (IF: 4.59)

34. K.H. Cho, O. Ribeiro, Y. Du, E. Tikhonova, J.S. Mortensen, K. Markham, P. Hariharan, C.J. Loland, L. Guan, B.K. Kobilka, B. Byrne, P.S. Chae
“Mesitylene-cored glucoside amphiphiles (MGAs) for membrane protein studies: importance of alkyl chain density in detergent efficacy”
Chemistry – A European Journal (2016), 10.1002/chem.201603338 (IF: 5.29) 

35. H.E. Bae, J.S. Mortensen, O. Ribeiro, Y. Du, M. Esan, B.K. Kobilka, C.J. Loland, B. Byrne, P.S. Chae
“Tandem Neopentyl Glycol Maltosides (TNMs) for Membrane Protein Stabilisation”
Chemical Communications (2016), 52(84):12104-12107 (IF: 6.57)

36. G. Khelashvili, S.G. Schmidt, L. Shi, J.A. Javitch, U. Gether, C.J. Loland, H. Weinstein.
“Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290”
Journal of Biological Chemistry (2016), 291(38):19786-99 (IF: 4.26)

37. M. Ehsan, Y. Du, N.J. Scull, E. Tikhonova, J. Tarrasch, J.S. Mortensen, C.J. Loland, G. Skiniotis, L. Guan, B. Byrne, B.K. Kobilka, P.S. Chae.
“Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies”
Journal of the American Chemical Society (2016), 138(11): 3789-3796 (IF: 13.0)

38. A. Sadaf, J.S. Mortensen, S. Capaldi, E. Tikhonova, P. Hariharan, O. de Castro Ribeiro, C.J. Loland, L. Guan, B. Byrne, P.S. Chae
“A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study”
Chemical Science (2016), 7(3): 1933-1939 (IF: 9.14)

39. H. Hussain, Y. Du, N.J. Scull, J. S. Mortensen, J. Tarrasch, H.E. Bae, C.J. Loland, B. Byrne, B.K. Kobilka, P.S. Chae
“Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation”
Chemistry – A European Journal (2016), 22(21): 7068-7073 (IF: 5.29)

40. M.A.B. Larsen, P. Plenge, J. Andersen, J.N.N. Eildal, A.S. Kristensen, K.P. Bøgesø, U. Gether, K. Strømgaard, B. Bang-Andersen, C.J. Loland
“Structure-activity relationship studies of citalopram derivatives: Examining substituents conferring selectivity for the allosteric site in the serotonin transporter”
British Journal of Pharmacology (2016), 173(5):925-36 (IF: 5.26)


41. C.B. Billesbølle, M.B. Krüger, L. Shi, M. Quick, Z. Li, S. Stolzenberg, J. Kniazeff, K. Gotfryd, J.A. Javitch, H. Weinstein, C.J. Loland, U. Gether
“Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter”
Journal of Biological Chemistry (2015), 290(44): 26725-26738 (IF: 4.26)

42. V. Jagalski, R. Barker, M.B. Thygesen, K. Gotfryd, M. Krüger, L. Shi, S. Maric, N. Bovet, M. Moulin, M. Haertlein, T. Günther Pomorski, C.J. Loland, M. Cardenas, “Grafted Biomembranes Containing Membrane Proteins - The Case for the Leucine Transporter”
Soft Matter (2015), 11(39): 7707-7711 (IF: 3.80)

43. K.H. Cho, Y. Du, N.J. Scull, P Hariharan. K. Gotfryd, C.J. Loland, L. Guan, B. Byrne, B.K Kobilka, P.S. Chae.
“Novel Xylene-linked Maltose Amphipiles (XMAs) for Membrane Protein Stabilisation”
Chemistry – A European Journal (2015), 21(28): 10008-10013 (IF: 5.29)

44. H.E. Bae, K. Gotfryd, J. Thomas, H. Hussain, M. Ehsan, J. Go, C.J. Loland, B. Byrne, P.S. Chae.
“Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation”
ChemBioChem – Communications (2015), 16(10): 1454-1459 (IF: 2.85)

45. S. Stolzenberg, M. Quick, C. Zhao, K. Gotfryd, G. Khelashvili, U. Gether, C.J. Loland, J.A. Javitch, S. Noskov, H. Weinstein, L. Shi.
“Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters”
Journal of Biological Chemistry (2015), 290(22): 13992-4003 (IF: 4.26)

46. K.H. Cho, M. Husri, A. Amin, K. Gotfryd, H.J. Lee, J. Go, J.W. Kim, C.J. Loland, L. Guan, B. Byrne, P.S. Chae.
“Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study”
Analyst (2015), 140(9): 3157-3163 (IF: 4.03)

47. C.J. Loland.
“The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters”
Biochimica Biophysica Acta – General Subjects (2015), 1850(3): 500-510 (IF: 3.66)


48. F.H. Hansen, T. Skjørringe, S. Yasmeen, N. Arends, M.A. Sahai, K. Erreger, T.F. Andreassen, M. Holy, P.J. Hamilton, V. Neergheen, M. Karlsborg, A.H. Newman, S. Pope, S.JR. Heales, L. Friberg, I. Law, L.H. Pinborg, H.H. Sitte, C. J. Loland, L. Shi, H. Weinstein, A. Galli, L.E. Hjermind, L.B. Møller, U. Gether.
“Missense Mutations in the Dopamine Transporter Gene Associated with Adult Parkinsonism and ADHD”
Journal of Clinical Investigation (2014), 124(7): 3107-3120 (IF: 13.2)

49. A.V. Pedersen, T.F. Andreassen, C.J. Loland.
“A Conserved Salt Bridge between Transmembrane Segment 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter”
Journal of Biological Chemistry (2014), 289(50): 35003-350014 (IF: 4.57)

50. O.M Okunola-Bakare, J. Cao, T. Kopajtic, J.L. Katz, C.J. Loland, L. Shi, A.H. Newman.
“Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues”
Journal of Medicinal Chemistry (2014), 57(3): 1000-1003 (IF: 5.45)


51. A.K. Banala, P. Zhang, P. Plenge, G. Cyriac, T. Kopajtic, J.L. Katz, C.J. Loland, A.H. Newman.
“Design and Synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites”
Journal of Medicinal Chemistry (2013), 56(23): 9709-9724 (IF: 5.48)

52. P.S. Chae, A.C. Kruse, K. Gotfryd, R.R. Rana, K.H. Cho, S.G. Rasmussen, H.E. Bae R., Chandra, U. Gether, L. Guan, B.K. Kobilka, C.J. Loland, B. Byrne, S.H. Gellman.
“Novel Tripod Amphiphiles for Membrane Protein Analysis”
Chemistry – a European Journal (2013), 56(23): 15645-15651 (IF: 5.70)

53. P.S. Chae, R.R. Rana, K. Gotfryd, S.G.F. Rasmussen, A.C. Kruse, K.H Cho, S. Capaldi, B. Kobilka, C.J. Loland, U. Gether, S. Banerjee, B. Byrne, J.K. Lee, S.H. Gellman
“Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Study”
Chemical Communications (2013), 49(23):2287-2289 (IF: 6.72)

54. P. Zhang, T.N. Jørgensen, C.J. Loland, A.H. Newman
“A Rhodamine-Labeled Citalopram Analogue as a High-Affinity Fluorescent Probe for the Serotonin Transporter”
Bioorganic & Medicinal Chemistry Letters (2013), 23(1):323-326 (IF: 2.33)

55. K.J. Simmons, K. Gotfryd, C.B. Billesbølle, C.J. Loland, U. Gether, C.W. Fishwick, A.P. Johnson
“A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT”
Molecular Membrane Biology (2013), 30(2):184-194 (IF: 1.73)


56. P. Plenge, L. Shi, T. Beuming, A.H. Newman, H. Weinstein, U. Gether, C.J. Loland.
“Steric Hindrance mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter”
Journal of Biological Chemistry (2012), 287(47):39316-39326 (IF: 4.65)

57. C.J. Loland, M. Mereu, O. M. Okunola, J. Cao, T. E. Prisinzano, T. Kopajtic, L. Shi, J. L. Katz, G. Tanda, A. H. Newman
“R-Modafinil (Armodafinil): A unique dopamine uptake inhibitor and potential medication for psychostimulant abuse”
Biological Psychiatry (2012), 72(5):405-413 (IF: 9.25)

58. P.S Chae, S.G. Rasmussen, R.R. Rana, K. Gotfryd, A.C. Kruse, A. Manglik, K.H. Cho, S. Nurva, U. Gether, L. Guan, C.J. Loland, B. Byrne, B.K. Kobilka, S.H. Gellman.
“A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins”
Chemistry (2012), 18(31):9485-9490 (IF: 5.83)

59. G. Sørensen, M. Weikop, D. Dencker, C.J. Loland, C. H. Bengtsen, J. H. Petersen, A. Fink-Jensen, G. Wörtwein, D. P. Woldbye.
“Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice”
Psychopharmacology (Berl) (2012), 222(4):565-577 (IF: 4.06)


60. A.S. Kristensen, J. Andersen, T.N. Jørgensen, L. Sørensen, J. Eriksen, C.J. Loland, K. Strømgaard, U. Gether.
“The SLC6 neurotransmitter transporters: structure, function and regulation”
Pharmacological Reviews (2011), 63(3):585-640 (IF: 20.2)

61. H. Bisgaard, M.A. Larsen, S. Mazier, T. Beuming, A.H. Newman, H. Weinstein, L. Shi, C.J. Loland, U. Gether.
“The binding sites for benztropines and dopamine in the dopamine transporter overlap”
Neuropharmacology (2011), 60(1):182-190 (IF: 4.81)


62. P.S. Chae, S.G. Rasmussen, R.R. Rana, K. Gotfryd, R. Chandra, M.A. Goren, A.C. Kruse, S. Nurva, C.J. Loland, Y. Pierre, D. Drew, J.L. Popot, D. Picot, B.G. Fox, L. Guan, U. Gether, B. Byrne, B. Kobilka, S.H. Gellman
“Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins”
Nature Methods (2010), 7(12):1003-1008 (IF: 20.7)

63. P.S. Chae, K. Gotfryd, J. Pacyna, L.J. Miercke, S.G. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B Byrne, U Gether, S.H. Gellman
“Tandem Facial Amphiphiles for Membrane Protein Stabilization”
Journal of the American Chemical Society (2010), 132(47):16750-16752 (IF: 9.02)


64. T. Beuming, J. Kniazeff; M.L. Bergmann, L. Shi, L. Gracia, K. Raniszewska, A.H. Newman, J.A. Javitch, H. Weinstein, U. Gether, and C.J. Loland
“The Binding Sites for Cocaine and Dopamine in the Dopamine Transporter are Overlapping”
Nature Neuroscience (2008), 11(7): 780-789 (IF: 14.2)

65. J. Kniazeff, L. Shi, C.J. Loland, H. Weinstein, and U. Gether
“An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter”
Journal of Biological Chemistry (2008), 283(25): 17691-17701 (IF: 5.52)

66. C.J. Loland, R.I. Desai, M.-F. Zou, J. Cao, P. Grundt, K. Gerstbrein, H.H. Sitte, A.H. Newman, J.L. Katz, and U. Gether
“Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors”
Molecular Pharmacology (2008), 73: 813-823 (IF: 4.71)


67. K.M. Kahlig, B.J. Lute, Y. Wei, C.J. Loland, U. Gether, J.A. Javitch, A. Galli
“Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine”
Molecular Pharmacology (2006), 70(2):542-548 (IF: 4.47)


68. J.H. Cha, M.-F. Zou, E.M. Adkins, S.G.F. Rasmussen, C.J. Loland, B. Shonenberger, U. Gether, and A.H. Newman
“Rhodamine-labeled 2β-carbomethoxy-3β-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter”
Journal of Medicinal Chemistry (2005), 48(24): 7513-7516 (IF: 4.97)

69. J. Kniazeff, C.J. Loland, N. Goldberg, M. Quick, S. Das, H.H. Sitte, J.A. Javitch, and U. Gether
“Intramolecular Cross-Linking in a Bacterial Homolog of Mammalian SLC6 Neurotransmitter Transporters Suggests an Evolutionary Conserved Role of Transmembrane Segments 7 and 8”
Neuropharmacology (2005), 49(6): 7024-7036 (IF: 3.84)


70. C. Bjerggaard, J. Fog, H. Hastrup, K. Madsen, C.J. Loland, J. Javitch, and U. Gether
“Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus but does not Require Canonical PDZ Domain Interactions”
Journal of Neuroscience (2004), 24(31): 7024-7036 (IF: 8.02)

71. C.J. Loland, C. Grånäs, J.A. Javitch, and U. Gether
“Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding”
Journal of Biological Chemistry (2004), 279(5): 3228-3238 (IF: 6.57)


72. C.J. Loland, K. Norgaard-Nielsen, and U. Gether
“Probing Dopamine Transporter Structure and Function by Zn2+-site Engineering”
European Journal of Pharmacology (2003), 479(1-3): 187-197 (IF: 2.35)

73. L. Norregaard, C.J. Loland, and U. Gether
“Evidence for distinct sodium, dopamine and cocaine dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter”
Journal of Biological Chemistry (2003), 278(33): 30587-30596 (IF: 6.41)

74. C. Grånäs, J. Ferrer, C.J. Loland, J.A. Javitch and U. Gether
“N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester and Substance P Receptor Stimulated Phosphorylation Without Impairing Transporter Internalization”
Journal of Biological Chemistry (2003), 278(7): 4990-5000 (IF: 6.41)


75. C.J. Loland, L. Norregaard, T. Litman and U. Gether
“Generation of an Activating Zn2+ Switch in the Dopamine Transporter: Mutation of an Intracellular Tyrosine Constitutively Alters the Conformational Equilibrium of the Transport Cycle”
Proceedings of the National Academy of Sciences USA (2002), 99(3): 1683-1688 (IF: 10.7)


76. N. MacAulay, A. Bendahan, C.J. Loland, T. Zeuthen, B. Kanner and U. Gether
“Engineered Zn2+ Switches in the GABA Transporter-1: Differential Effects on GABA Uptake and Currents”
Journal of Biological Chemistry (2001), 276(44): 40476-40485 (IF: 6.61)

77. U. Gether, L. Norregaard and C.J. Loland
“Delineating Structure-Function Relationships in the Dopamine Transporter from Natural and Engineered Zn2+ Binding Sites”
Life Sciences (2001), 68(19-20):2187-2198 (IF: 1.79)


78. L. Norregaard, I. Visiers, C.J. Loland, J. Ballasteros, H. Weinstein and U. Gether “Structural Probing of a Microdomain in the Dopamine Transporter by Engineering of Artificial Zn2+ Binding Sites.”
Biochemistry (2000), 39(51): 15836-15846


79. C.J. Loland, L. Norregaard, and U. Gether
“Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter. Identification of a Conserved Glutamic Acid as a Third Coordinate in the Endogenous Zn2+ Binding site”
Journal of Biological Chemistry. (1999), 274(52): 36928-36934 (IF: 7.67)

I.II Book Chapters

80. F.A. Chaudhry, C.J. Loland, A. Ortega, A. Schousboe (Eds)
“Special issue on neurotransmitter transporters”
Neuropharmacology (2019) 161:107859. doi: 10.1016/j.neuropharm.2019.107859

81. J.S. Mortensen, C.J. Loland
“Short-range distances measurement by transition metal ion FRET”
In ‘Biophysics of Membrane Proteins’, (V. Postis & A. Goldman, ed.) Methods in Molecular Biology, Springer Nature, London (2019)

82. C.J. Loland, C. Sanchez, P. Plenge, K.P. Bøgesø, B. Bang-Andersen
“Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target”
In ‘Allosterism in Drug Discovery’ Royal Society of Chemistry, Drug Discovery Series no. 65 (ed. D. Doller), (2017) page 360-380. doi: 10.1039/9781782629276

83. C.J. Loland and U. Gether
“Neurotransmitter Transporters: Structure, Function and Drug Binding”
in ‘Textbook of Drug Design and Discovery’, 5th edition (ed. U. Madsen), Taylor & Francis Group, LLC, 2015

84. C.J. Loland and U. Gether
“Neurotransmitter Transporters: Structure and Function”
in ‘Textbook of Drug Design and Discovery’, 4th edition (ed.. U. Madsen), Taylor & Francis Group, LLC, 2010

85. C.J. Loland, and U. Gether
“Insights from Endogenous and Engineered Zn2+-binding Sites in Monoamine Transporters”
In Molecular Neuropharmacology: Strategies and Methods (Schousboe, A. and Bräuner-Osborne, H., ed.) Humana Press, Totowa, New Jersey (2004), 191-213

II. Patent applications

“Use of dihydro-isobenzofuran in combination with serotonin reuptake inhibitors for CNS disease e.g. depression, anxiety, bipolar disorder, obsessive compulsory disorder”
Inventors: K.P. Bogeso, K. Juhl, H. Zhong, C.J. Loland
Patent Number: WO2013110313-A1
Patent Assignee Name and Code: LUNDBECK AS H(LUND-C)
Derwent Primary Accession Number: 2013-M11364 [55]