Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?

Research output: Contribution to journalReviewpeer-review

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Sensing and regulation of cell volume - we know so much and yet understand so little : TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? / Toft-Bertelsen, Trine L.; Larsen, Brian R.; MacAulay, Nanna.

In: Channels (Austin), Vol. 12, No. 1, 2018, p. 100-108.

Research output: Contribution to journalReviewpeer-review

Harvard

Toft-Bertelsen, TL, Larsen, BR & MacAulay, N 2018, 'Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?', Channels (Austin), vol. 12, no. 1, pp. 100-108. https://doi.org/10.1080/19336950.2018.1438009

APA

Toft-Bertelsen, T. L., Larsen, B. R., & MacAulay, N. (2018). Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? Channels (Austin), 12(1), 100-108. https://doi.org/10.1080/19336950.2018.1438009

Vancouver

Toft-Bertelsen TL, Larsen BR, MacAulay N. Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? Channels (Austin). 2018;12(1):100-108. https://doi.org/10.1080/19336950.2018.1438009

Author

Toft-Bertelsen, Trine L. ; Larsen, Brian R. ; MacAulay, Nanna. / Sensing and regulation of cell volume - we know so much and yet understand so little : TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?. In: Channels (Austin). 2018 ; Vol. 12, No. 1. pp. 100-108.

Bibtex

@article{b189b4dd0b6f4cc58a0f5ae2175f3ca3,
title = "Sensing and regulation of cell volume - we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?",
abstract = "Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, non-physiological osmotic gradients. The TRPV4 ion channel responds to volume increase irrespectively of the molecular mechanism underlying cell swelling, and is thus considered a sensor of volume changes. Evidence pointing towards the involvement of TRPV4 in subsequent volume regulatory mechanisms is intriguing, yet far from conclusive. We here present an experimental setting with astrocytic cell swelling in the absence of externally applied osmotic gradients, and the lack of evidence for involvement of TRPV4 in this regulatory volume response. Our aim with these new data and the preceding discussion is to stimulate further experimental effort in this area of research to clarify the role of TRPV4 and other channels and transporters in regulatory volume responses.",
keywords = "aquaporins, osmo-sensing, volume regulation, volume-sensitive ion channels, transient receptor potential vanilloid 4 channel, TRPV4",
author = "Toft-Bertelsen, {Trine L.} and Larsen, {Brian R.} and Nanna MacAulay",
year = "2018",
doi = "10.1080/19336950.2018.1438009",
language = "English",
volume = "12",
pages = "100--108",
journal = "Channels",
issn = "1933-6950",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Sensing and regulation of cell volume - we know so much and yet understand so little

T2 - TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?

AU - Toft-Bertelsen, Trine L.

AU - Larsen, Brian R.

AU - MacAulay, Nanna

PY - 2018

Y1 - 2018

N2 - Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, non-physiological osmotic gradients. The TRPV4 ion channel responds to volume increase irrespectively of the molecular mechanism underlying cell swelling, and is thus considered a sensor of volume changes. Evidence pointing towards the involvement of TRPV4 in subsequent volume regulatory mechanisms is intriguing, yet far from conclusive. We here present an experimental setting with astrocytic cell swelling in the absence of externally applied osmotic gradients, and the lack of evidence for involvement of TRPV4 in this regulatory volume response. Our aim with these new data and the preceding discussion is to stimulate further experimental effort in this area of research to clarify the role of TRPV4 and other channels and transporters in regulatory volume responses.

AB - Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, non-physiological osmotic gradients. The TRPV4 ion channel responds to volume increase irrespectively of the molecular mechanism underlying cell swelling, and is thus considered a sensor of volume changes. Evidence pointing towards the involvement of TRPV4 in subsequent volume regulatory mechanisms is intriguing, yet far from conclusive. We here present an experimental setting with astrocytic cell swelling in the absence of externally applied osmotic gradients, and the lack of evidence for involvement of TRPV4 in this regulatory volume response. Our aim with these new data and the preceding discussion is to stimulate further experimental effort in this area of research to clarify the role of TRPV4 and other channels and transporters in regulatory volume responses.

KW - aquaporins

KW - osmo-sensing

KW - volume regulation

KW - volume-sensitive ion channels

KW - transient receptor potential vanilloid 4 channel

KW - TRPV4

U2 - 10.1080/19336950.2018.1438009

DO - 10.1080/19336950.2018.1438009

M3 - Review

C2 - 29424275

VL - 12

SP - 100

EP - 108

JO - Channels

JF - Channels

SN - 1933-6950

IS - 1

ER -

ID: 197959846