Precapillary sphincters maintain perfusion in the cerebral cortex

Research output: Contribution to journalJournal articlepeer-review

Standard

Precapillary sphincters maintain perfusion in the cerebral cortex. / Grubb, Søren; Cai, Changsi; Hald, Bjørn O; Khennouf, Lila; Murmu, Reena Prity; Jensen, Aske G K; Fordsmann, Jonas; Zambach, Stefan; Lauritzen, Martin.

In: Nature Communications, Vol. 11, No. 1, 395, 2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Grubb, S, Cai, C, Hald, BO, Khennouf, L, Murmu, RP, Jensen, AGK, Fordsmann, J, Zambach, S & Lauritzen, M 2020, 'Precapillary sphincters maintain perfusion in the cerebral cortex', Nature Communications, vol. 11, no. 1, 395. https://doi.org/10.1038/s41467-020-14330-z

APA

Grubb, S., Cai, C., Hald, B. O., Khennouf, L., Murmu, R. P., Jensen, A. G. K., Fordsmann, J., Zambach, S., & Lauritzen, M. (2020). Precapillary sphincters maintain perfusion in the cerebral cortex. Nature Communications, 11(1), [395]. https://doi.org/10.1038/s41467-020-14330-z

Vancouver

Grubb S, Cai C, Hald BO, Khennouf L, Murmu RP, Jensen AGK et al. Precapillary sphincters maintain perfusion in the cerebral cortex. Nature Communications. 2020;11(1). 395. https://doi.org/10.1038/s41467-020-14330-z

Author

Grubb, Søren ; Cai, Changsi ; Hald, Bjørn O ; Khennouf, Lila ; Murmu, Reena Prity ; Jensen, Aske G K ; Fordsmann, Jonas ; Zambach, Stefan ; Lauritzen, Martin. / Precapillary sphincters maintain perfusion in the cerebral cortex. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{5c39d6e393ac4008bf252295376394a1,
title = "Precapillary sphincters maintain perfusion in the cerebral cortex",
abstract = "Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the penetrating arteriole and first order capillary, linking blood flow in capillaries to the arteriolar inflow. The sphincters are encircled by contractile mural cells, which are capable of bidirectional control of the length and width of the enclosed vessel segment. The hemodynamic consequence is that precapillary sphincters can generate the largest changes in the cerebrovascular flow resistance of all brain vessel segments, thereby controlling capillary flow while protecting the downstream capillary bed and brain tissue from adverse pressure fluctuations. Cortical spreading depolarization constricts sphincters and causes vascular trapping of blood cells. Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.",
author = "S{\o}ren Grubb and Changsi Cai and Hald, {Bj{\o}rn O} and Lila Khennouf and Murmu, {Reena Prity} and Jensen, {Aske G K} and Jonas Fordsmann and Stefan Zambach and Martin Lauritzen",
year = "2020",
doi = "10.1038/s41467-020-14330-z",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Precapillary sphincters maintain perfusion in the cerebral cortex

AU - Grubb, Søren

AU - Cai, Changsi

AU - Hald, Bjørn O

AU - Khennouf, Lila

AU - Murmu, Reena Prity

AU - Jensen, Aske G K

AU - Fordsmann, Jonas

AU - Zambach, Stefan

AU - Lauritzen, Martin

PY - 2020

Y1 - 2020

N2 - Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the penetrating arteriole and first order capillary, linking blood flow in capillaries to the arteriolar inflow. The sphincters are encircled by contractile mural cells, which are capable of bidirectional control of the length and width of the enclosed vessel segment. The hemodynamic consequence is that precapillary sphincters can generate the largest changes in the cerebrovascular flow resistance of all brain vessel segments, thereby controlling capillary flow while protecting the downstream capillary bed and brain tissue from adverse pressure fluctuations. Cortical spreading depolarization constricts sphincters and causes vascular trapping of blood cells. Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.

AB - Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition between the penetrating arteriole and first order capillary, linking blood flow in capillaries to the arteriolar inflow. The sphincters are encircled by contractile mural cells, which are capable of bidirectional control of the length and width of the enclosed vessel segment. The hemodynamic consequence is that precapillary sphincters can generate the largest changes in the cerebrovascular flow resistance of all brain vessel segments, thereby controlling capillary flow while protecting the downstream capillary bed and brain tissue from adverse pressure fluctuations. Cortical spreading depolarization constricts sphincters and causes vascular trapping of blood cells. Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.

U2 - 10.1038/s41467-020-14330-z

DO - 10.1038/s41467-020-14330-z

M3 - Journal article

C2 - 31959752

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 395

ER -

ID: 234954006