Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

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Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure. / Vestergaard, Mark B; Ghanizada, Hashmat; Lindberg, Ulrich; Arngrim, Nanna; Paulson, Olaf B.; Gjedde, Albert; Ashina, Messoud; Larsson, Henrik B W.

In: Cerebral Cortex, Vol. 32, No. 6, 2022, p. 1295–1306.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vestergaard, MB, Ghanizada, H, Lindberg, U, Arngrim, N, Paulson, OB, Gjedde, A, Ashina, M & Larsson, HBW 2022, 'Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure', Cerebral Cortex, vol. 32, no. 6, pp. 1295–1306. https://doi.org/10.1093/cercor/bhab294

APA

Vestergaard, M. B., Ghanizada, H., Lindberg, U., Arngrim, N., Paulson, O. B., Gjedde, A., Ashina, M., & Larsson, H. B. W. (2022). Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure. Cerebral Cortex, 32(6), 1295–1306. https://doi.org/10.1093/cercor/bhab294

Vancouver

Vestergaard MB, Ghanizada H, Lindberg U, Arngrim N, Paulson OB, Gjedde A et al. Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure. Cerebral Cortex. 2022;32(6):1295–1306. https://doi.org/10.1093/cercor/bhab294

Author

Vestergaard, Mark B ; Ghanizada, Hashmat ; Lindberg, Ulrich ; Arngrim, Nanna ; Paulson, Olaf B. ; Gjedde, Albert ; Ashina, Messoud ; Larsson, Henrik B W. / Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure. In: Cerebral Cortex. 2022 ; Vol. 32, No. 6. pp. 1295–1306.

Bibtex

@article{3358677619284bee9582446ba0aae865,
title = "Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure",
abstract = "Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypothesis of upregulation of cerebral glycolysis mediated by hypoxic sensing. Describing the pathways counteracting brain hypoxia could help us understand brain diseases associated with hypoxia. A total of 65 subjects participated in this study: 30 subjects were exposed to poikilocapnic hypoxia, 14 were exposed to isocapnic hypoxia, and 21 were exposed to carbon monoxide (CO). Using this setup, we examined whether lactate production reacts to an overall reduction in arterial oxygen concentration or solely to reduced arterial oxygen partial pressure. We measured cerebral blood flow (CBF), CMRO2, and lactate concentrations by magnetic resonance imaging and spectroscopy. CBF increased (P < 10-4), whereas the CMRO2 remained unaffected (P > 0.076) in all groups, as expected. Lactate increased in groups inhaling hypoxic air (poikilocapnic hypoxia: $0.0136\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P < 10-6; isocapnic hypoxia: $0.0142\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P = 0.003) but was unaffected by CO (P = 0.36). Lactate production was not associated with reduced CMRO2. These results point toward a mechanism of lactate production by upregulation of glycolysis mediated by sensing a reduced arterial oxygen pressure. The released lactate may act as a signaling molecule engaged in vasodilation.",
author = "Vestergaard, {Mark B} and Hashmat Ghanizada and Ulrich Lindberg and Nanna Arngrim and Paulson, {Olaf B.} and Albert Gjedde and Messoud Ashina and Larsson, {Henrik B W}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/cercor/bhab294",
language = "English",
volume = "32",
pages = "1295–1306",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure

AU - Vestergaard, Mark B

AU - Ghanizada, Hashmat

AU - Lindberg, Ulrich

AU - Arngrim, Nanna

AU - Paulson, Olaf B.

AU - Gjedde, Albert

AU - Ashina, Messoud

AU - Larsson, Henrik B W

N1 - © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypothesis of upregulation of cerebral glycolysis mediated by hypoxic sensing. Describing the pathways counteracting brain hypoxia could help us understand brain diseases associated with hypoxia. A total of 65 subjects participated in this study: 30 subjects were exposed to poikilocapnic hypoxia, 14 were exposed to isocapnic hypoxia, and 21 were exposed to carbon monoxide (CO). Using this setup, we examined whether lactate production reacts to an overall reduction in arterial oxygen concentration or solely to reduced arterial oxygen partial pressure. We measured cerebral blood flow (CBF), CMRO2, and lactate concentrations by magnetic resonance imaging and spectroscopy. CBF increased (P < 10-4), whereas the CMRO2 remained unaffected (P > 0.076) in all groups, as expected. Lactate increased in groups inhaling hypoxic air (poikilocapnic hypoxia: $0.0136\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P < 10-6; isocapnic hypoxia: $0.0142\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P = 0.003) but was unaffected by CO (P = 0.36). Lactate production was not associated with reduced CMRO2. These results point toward a mechanism of lactate production by upregulation of glycolysis mediated by sensing a reduced arterial oxygen pressure. The released lactate may act as a signaling molecule engaged in vasodilation.

AB - Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypothesis of upregulation of cerebral glycolysis mediated by hypoxic sensing. Describing the pathways counteracting brain hypoxia could help us understand brain diseases associated with hypoxia. A total of 65 subjects participated in this study: 30 subjects were exposed to poikilocapnic hypoxia, 14 were exposed to isocapnic hypoxia, and 21 were exposed to carbon monoxide (CO). Using this setup, we examined whether lactate production reacts to an overall reduction in arterial oxygen concentration or solely to reduced arterial oxygen partial pressure. We measured cerebral blood flow (CBF), CMRO2, and lactate concentrations by magnetic resonance imaging and spectroscopy. CBF increased (P < 10-4), whereas the CMRO2 remained unaffected (P > 0.076) in all groups, as expected. Lactate increased in groups inhaling hypoxic air (poikilocapnic hypoxia: $0.0136\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P < 10-6; isocapnic hypoxia: $0.0142\ \frac{\mathrm{mmol}/\mathrm{L}}{\Delta{\mathrm{S}}_{\mathrm{a}}{\mathrm{O}}_2}$, P = 0.003) but was unaffected by CO (P = 0.36). Lactate production was not associated with reduced CMRO2. These results point toward a mechanism of lactate production by upregulation of glycolysis mediated by sensing a reduced arterial oxygen pressure. The released lactate may act as a signaling molecule engaged in vasodilation.

U2 - 10.1093/cercor/bhab294

DO - 10.1093/cercor/bhab294

M3 - Journal article

C2 - 34448827

VL - 32

SP - 1295

EP - 1306

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 6

ER -

ID: 279260778