Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain.

Research output: Contribution to journalJournal articleResearchpeer-review

  • D F Wong
  • H N Wagner
  • R F Dannals
  • J M Links
  • J J Frost
  • H T Ravert
  • A A Wilson
  • A E Rosenbaum
  • Gjedde, Albert
  • K H Douglass
D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females.
Original languageEnglish
Issue number4681
Pages (from-to)1393-6
Number of pages3
Publication statusPublished - 1984
Externally publishedYes

ID: 14943673