Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning

Research output: Contribution to journalJournal articlepeer-review

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Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning. / Hervig, M. E.; Fiddian, L.; Piilgaard, L.; Bozič, T.; Blanco-Pozo, M.; Knudsen, C.; Olesen, S. F.; Alsiö, J.; Robbins, T. W.

In: Cerebral Cortex, Vol. 30, No. 3, 2020, p. 1016-1029.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hervig, ME, Fiddian, L, Piilgaard, L, Bozič, T, Blanco-Pozo, M, Knudsen, C, Olesen, SF, Alsiö, J & Robbins, TW 2020, 'Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning', Cerebral Cortex, vol. 30, no. 3, pp. 1016-1029. https://doi.org/10.1093/cercor/bhz144

APA

Hervig, M. E., Fiddian, L., Piilgaard, L., Bozič, T., Blanco-Pozo, M., Knudsen, C., Olesen, S. F., Alsiö, J., & Robbins, T. W. (2020). Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning. Cerebral Cortex, 30(3), 1016-1029. https://doi.org/10.1093/cercor/bhz144

Vancouver

Hervig ME, Fiddian L, Piilgaard L, Bozič T, Blanco-Pozo M, Knudsen C et al. Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning. Cerebral Cortex. 2020;30(3):1016-1029. https://doi.org/10.1093/cercor/bhz144

Author

Hervig, M. E. ; Fiddian, L. ; Piilgaard, L. ; Bozič, T. ; Blanco-Pozo, M. ; Knudsen, C. ; Olesen, S. F. ; Alsiö, J. ; Robbins, T. W. / Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning. In: Cerebral Cortex. 2020 ; Vol. 30, No. 3. pp. 1016-1029.

Bibtex

@article{a0162fc4f58549aca477d0dee08d1571,
title = "Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning",
abstract = "Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with the orbitofrontal cortex (OFC) playing a prominent role. The OFC is a functionally heterogeneous region, but potential differential roles of lateral (lOFC) and medial (mOFC) portions in visual reversal learning have yet to be determined. We investigated the effects of pharmacological inactivation of mOFC and lOFC on a deterministic serial visual reversal learning task for rats. For reference, we also targeted other areas previously implicated in reversal learning: prelimbic (PrL) and infralimbic (IL) prefrontal cortex, and basolateral amygdala (BLA). Inactivating mOFC and lOFC produced opposite effects; lOFC impairing, and mOFC improving, performance in the early, perseverative phase specifically. Additionally, mOFC inactivation enhanced negative feedback sensitivity, while lOFC inactivation diminished feedback sensitivity in general. mOFC and lOFC inactivation also affected novel visual discrimination learning differently; lOFC inactivation paradoxically improved learning, and mOFC inactivation had no effect. We also observed dissociable roles of the OFC and the IL/PrL. Whereas the OFC inactivation affected only perseveration, IL/PrL inactivation improved learning overall. BLA inactivation did not affect perseveration, but improved the late phase of reversal learning. These results support opponent roles of the rodent mOFC and lOFC in deterministic visual reversal learning.",
keywords = "amygdala, orbitofrontal cortex, prefrontal cortex, reversal learningm, visual discrimination",
author = "Hervig, {M. E.} and L. Fiddian and L. Piilgaard and T. Bozi{\v c} and M. Blanco-Pozo and C. Knudsen and Olesen, {S. F.} and J. Alsi{\"o} and Robbins, {T. W.}",
year = "2020",
doi = "10.1093/cercor/bhz144",
language = "English",
volume = "30",
pages = "1016--1029",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning

AU - Hervig, M. E.

AU - Fiddian, L.

AU - Piilgaard, L.

AU - Bozič, T.

AU - Blanco-Pozo, M.

AU - Knudsen, C.

AU - Olesen, S. F.

AU - Alsiö, J.

AU - Robbins, T. W.

PY - 2020

Y1 - 2020

N2 - Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with the orbitofrontal cortex (OFC) playing a prominent role. The OFC is a functionally heterogeneous region, but potential differential roles of lateral (lOFC) and medial (mOFC) portions in visual reversal learning have yet to be determined. We investigated the effects of pharmacological inactivation of mOFC and lOFC on a deterministic serial visual reversal learning task for rats. For reference, we also targeted other areas previously implicated in reversal learning: prelimbic (PrL) and infralimbic (IL) prefrontal cortex, and basolateral amygdala (BLA). Inactivating mOFC and lOFC produced opposite effects; lOFC impairing, and mOFC improving, performance in the early, perseverative phase specifically. Additionally, mOFC inactivation enhanced negative feedback sensitivity, while lOFC inactivation diminished feedback sensitivity in general. mOFC and lOFC inactivation also affected novel visual discrimination learning differently; lOFC inactivation paradoxically improved learning, and mOFC inactivation had no effect. We also observed dissociable roles of the OFC and the IL/PrL. Whereas the OFC inactivation affected only perseveration, IL/PrL inactivation improved learning overall. BLA inactivation did not affect perseveration, but improved the late phase of reversal learning. These results support opponent roles of the rodent mOFC and lOFC in deterministic visual reversal learning.

AB - Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with the orbitofrontal cortex (OFC) playing a prominent role. The OFC is a functionally heterogeneous region, but potential differential roles of lateral (lOFC) and medial (mOFC) portions in visual reversal learning have yet to be determined. We investigated the effects of pharmacological inactivation of mOFC and lOFC on a deterministic serial visual reversal learning task for rats. For reference, we also targeted other areas previously implicated in reversal learning: prelimbic (PrL) and infralimbic (IL) prefrontal cortex, and basolateral amygdala (BLA). Inactivating mOFC and lOFC produced opposite effects; lOFC impairing, and mOFC improving, performance in the early, perseverative phase specifically. Additionally, mOFC inactivation enhanced negative feedback sensitivity, while lOFC inactivation diminished feedback sensitivity in general. mOFC and lOFC inactivation also affected novel visual discrimination learning differently; lOFC inactivation paradoxically improved learning, and mOFC inactivation had no effect. We also observed dissociable roles of the OFC and the IL/PrL. Whereas the OFC inactivation affected only perseveration, IL/PrL inactivation improved learning overall. BLA inactivation did not affect perseveration, but improved the late phase of reversal learning. These results support opponent roles of the rodent mOFC and lOFC in deterministic visual reversal learning.

KW - amygdala

KW - orbitofrontal cortex

KW - prefrontal cortex

KW - reversal learningm

KW - visual discrimination

U2 - 10.1093/cercor/bhz144

DO - 10.1093/cercor/bhz144

M3 - Journal article

C2 - 31343680

AN - SCOPUS:85083041109

VL - 30

SP - 1016

EP - 1029

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 3

ER -

ID: 242707684