An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

Research output: Contribution to journalJournal articleResearchpeer-review

The mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like cocaine. The muscarinic M(4) acetylcholine receptor subtype is centrally involved in the regulation of dopamine release in striatal areas. Consequently, striatal M(4) receptors could be a novel target for modulating psychostimulant effects of cocaine.
Original languageEnglish
Issue number2
Pages (from-to)277-87
Number of pages11
Publication statusPublished - 2012

ID: 48447898