Thomas Zeuthen

Thomas Zeuthen

Professor emeritus


  1. 2022
  2. Published

    Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

    MacAulay, Nanna, Keep, R. F. & Zeuthen, Thomas, 2022, In: Fluids and Barriers of the CNS. 19, 1, 18 p., 26.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

    Oernbo, E. K., Steffensen, Annette Buur, Khamesi, P. R., Toft-Bertelsen, Trine Lisberg, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, N. J., Tritsaris, Katerina, Simonsen, A. H., Lolansen, Sara Diana, Andreassen, Søren Norge, Hasselbalch, Steen, Zeuthen, Thomas, Rose, C. R., Kurtcuoglu, V. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2016
  5. Published

    Structural and functional significance of water permeation through cotransporters

    Zeuthen, Thomas, Gorraitz, E., Her, K., Wright, E. M. & Loo, D. D. F., 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. E6887-E6894

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2014
  7. Published

    Response to comments on "Local impermeant anions establish the neuronal chloride concentration"

    Glykys, J., Dzhala, V., Egawa, K., Balena, T., Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, Thomas & Staley, K. J., 5 Sep 2014, In: Science (New York, N.Y.). 345, 6201, 2 p., 1130-D.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Local impermeant anions establish the neuronal chloride concentration

    Glykys, J., Dzhala, V., Egawa, K., Balena, T., Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, Thomas & Staley, K. J., 7 Feb 2014, In: Science (New York, N.Y.). 343, 6171, p. 670-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2013
  10. Published

    Osmotic water transport in aquaporins: evidence for a stochastic mechanism

    Zeuthen, Thomas, Alsterfjord, M., Beitz, E. & MacAulay, Nanna, 15 Oct 2013, In: Journal of Physiology. 591, Pt 20, p. 5017-29 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2012
  12. Published

    Glial K(+) Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps

    MacAulay, Nanna & Zeuthen, Thomas, Nov 2012, In: Neurochemical Research. 37, 11, p. 2299-2309 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Cotransport of water by Na¿-K¿-2Cl¿ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2

    Zeuthen, Thomas & MacAulay, Nanna, 1 Mar 2012, In: Journal of Physiology. 590, Pt 5, p. 1139-54 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2011
  15. Published

    Enhancement of proton conductance by mutations of the selectivity filter of aquaporin-1

    Li, H., Chen, H., Steinbronn, C., Wu, B., Beitz, E., Zeuthen, Thomas & Voth, G. A., 8 Apr 2011, In: Journal of Molecular Biology. 407, 4, p. 607-20 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Requirement for asparagine in the aquaporin NPA sequence signature motifs for cation exclusion

    Wree, D., Wu, B., Zeuthen, Thomas & Beitz, E., 1 Mar 2011, In: FEBS Journal. 278, 5, p. 740-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2010
  18. Published

    Cotransport of water by the Na+-K+-2Cl(-) cotransporter NKCC1 in mammalian epithelial cells

    Hamann, Steffen, Herrera-Perez, J. J., Zeuthen, Thomas, Alvarez-Leefmans, F. J., Hamann, Steffen, Herrera-Perez, J. J., Zeuthen, T. & Alvarez-Leefmans, F. J., 1 Nov 2010, In: Journal of Physiology. 588, Pt 21, p. 4089-101 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Water transport between CNS compartments: contributions of aquaporins and cotransporters

    MacAulay, Nanna & Zeuthen, Thomas, Jul 2010, In: Neuroscience. 168, 4, p. 941-56 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Water-transporting proteins

    Zeuthen, Thomas, 2010, In: Journal of Membrane Biology. 234, 2, p. 57-73 16 p.

    Research output: Contribution to journalReviewResearch

  21. 2009
  22. Published

    Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes

    Moeller, H. B., Fenton, R. A., Zeuthen, Thomas & MacAulay, Nanna, Dec 2009, In: Neuroscience. 164, 4, p. 1674-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Ammonia and urea permeability of mammalian aquaporins

    Litman, Thomas, Søgaard, R. & Zeuthen, Thomas, 2009, In: Handbook of Experimental Pharmacology. 190, p. 327-58 31 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH

    Søgaard, R., Alsterfjord, M., MacAulay, Nanna & Zeuthen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 733-43 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Analysis of mice with targeted deletion of AQP9 gene provides conclusive evidence for expression of AQP9 in neurons

    Mylonakou, M. N., Petersen, P. H., Rinvik, E., Rojek, A., Valdimarsdottir, E., Zelenin, S., Zeuthen, Thomas, Nielsen, S., Ottersen, O. P. & Amiry-Moghaddam, M., 2009, In: Journal of Neuroscience Research. 87, 6, p. 1310-22 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space

    Østby, I., Øyehaug, L., Einevoll, G. T., Nagelhus, E. A., Plahte, E., Zeuthen, Thomas, Lloyd, C. M., Ottersen, O. P. & Omholt, S. W., 2009, In: PLoS Computational Biology. 5, 1, p. e1000272

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Chloride transporters as water pumps: Elements in a new model of epithelial water transport: From Molecules to diseases

    MacAulay, Nanna, Hamann, Steffen & Zeuthen, Thomas, 2009, Physiology and pathology of chloride transporters and channels in the nervous system. Alvarez-Leefmans, F. & Delpire, E. (eds.). Amsterdam, The Netherlands: Academic Press, p. 547-568 22 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  28. Published

    Concerted action of two cation filters in the aquaporin water channel

    Wu, B., Steinbronn, C., Alsterfjord, M., Zeuthen, Thomas & Beitz, E., 2009, In: EMBO Journal. 28, 15, p. 2188-2194 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2008
  30. Published

    New isoforms of rat Aquaporin-4.

    Moe, S. E., Sorbo, J. G., Søgaard, R., Zeuthen, Thomas, Petter Ottersen, O. & Holen, T., 2008, In: Genomics. 91, 4, p. 367-77 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2007
  32. Published

    Molecular water pumps: or how water can move uphill across epithelia

    Zeuthen, Thomas, 2007, In: Physiology News. 68, p. 3-5 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide.

    Søgaard, R. & Zeuthen, Thomas, 2007, In: Pflügers Archiv: European Journal of Physiology. 456, 2, p. 285-92 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The mechanism of water transport in Na+-coupled glucose transporters expressed in Xenopus oocytes

    Zeuthen, Thomas, 2007, In: Biophysical Journal. 93, 4, p. 1413-1416 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Water transport by GLUT2 expressed in Xenopus laevis oocytes

    Zeuthen, Thomas, Zeuthen, E. & MacAulay, Nanna, 2007, In: Journal of Physiology. 579, 2, p. 345-361 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2006
  37. Published

    Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei

    Zeuthen, Thomas, Wu, B. H., Pavlovic-Djuranovic, S., Holm, L. M., Uzcategui, N. L., Duszenko, M., Kun, J. F. J., Schultz, J. E. & Beitz, E., 2006, In: Molecular Microbiology. 61, 6, p. 1598-1608 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia and protons

    Beitz, E., Wu, B., Holm, Lars Morten, Schultz, J. E. & Zeuthen, Thomas, 2006, In: Proceedings of the National Academy of Science of the United States of America. 103(2), p. 269-274

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2005
  40. Published

    NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes

    Holm, L. M., Jahn, T. P., Møller, A. L. B., Schjoerring, Jan K., Ferri, D., Klærke, Dan Arne & Zeuthen, Thomas, 2005, In: Pflügers Archiv: European Journal of Physiology. 450, 6, p. 415-428 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Water permeability of Na+-K+-2C1- cotransporters in mammalian epithelial cells

    Hammann, S., Herrera-Perez, J. J., Bundgaard, M., Alvarez-Leefmans, F. J. & Zeuthen, Thomas, 2005, In: Journal of Physiology. 568, p. 123-135

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution

    Zeuthen, Thomas, Belhage, B. & Zeuthen, E., 2005, In: Journal of Physiology. 570, 3, p. 485-99 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2004
  44. Published

    Aquaporin 6 is permeable to glycerol and urea

    Holm, L. M., Klærke, Dan Arne & Zeuthen, Thomas, 2004, In: Pflügers Archiv: European Journal of Physiology. 448, p. 181-186 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Aquaporin homologues in plants and mammals transport ammonia

    Jahn, T. P., Møller, A. L. B., Zeuthen, Thomas, Holm, Lars Morten, Klærke, Dan Arne, Mohsin, B., Kühlbrandt, W. & Schjoerring, Jan K., 2004, In: FEBS Letters. 574, 1-3, p. 31-36 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Molecular cloning of a K+ channel from the malaria parasite Plasmodium falciparum

    Ellekvist, P., Ricke, C. H., Litman, Thomas, Salanti, Ali, Colding, H., Zeuthen, Thomas & Klærke, Dan Arne, 2004, In: Biochemical and Biophysical Research Communications. 318, 2, p. 477-84 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Water transport in brain: Role of cotransporters

    MacAulay, Nanna, Hamann, S. & Zeuthen, Thomas, 2004, In: Neuroscience. 129, 4, p. 1031-1044

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2003
  49. Published

    Cotransport of H+, lactate, and H2O in porcine retinal pigment epithelial cells

    Hamann, S., Kiilgaard, J. F., Cour, M. L., Prause, J. U. & Zeuthen, Thomas, 2003, In: Experimental Eye Research. 76, p. 493-504

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

    MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2002
  52. Published

    Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1

    MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1

    MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 2002, In: Journal of Physiology. 544, 2, p. 447-458

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Cotransporters as molecular water pumps

    Zeuthen, Thomas & MacAulay, Nanna, 2002, In: International Review of Cytology. 215, p. 259-84 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    General models for water transport across leaky epithelia

    Zeuthen, Thomas, 2002, In: International Review of Cytology. 215, p. 285-317

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Measurement of cell volume changes by fluorescence self-quenching

    Hamann, Steffen, Kiilgaard, J. F., Litman, Thomas, Alvarez-Leefmans, F. J., Winther, B. R. & Zeuthen, Thomas, 2002, In: Journal of Fluorescence. 12, 2, p. 139-145 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Mobility of ions, sugar, and water in the cytoplasm of Xenopus oocytes expressing Na (+)-coupled sugar transporters (SGLT1)

    Zeuthen, Thomas, Zeuthen, E. & Klærke, Dan Arne, 2002, In: Journal of Physiology. 542, p. 71-87

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes

    MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Passive water transport in biological pores

    Zeuthen, Thomas & MacAulay, Nanna, 2002, In: International Review of Cytology. 215, p. 203-230

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Water pumps

    Loo, D. D. F., Wright, E. M. & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, p. 53-60

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 2001
  62. Published

    Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

    MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit.

    Zeuthen, Thomas, Meinild, A. K., Loo, D. D., Wright, E. M. & Klærke, Dan Arne, 2001, In: Journal of Physiology. 531, 3, p. 631-44 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. 2000
  65. Published

    Transport of protons and lactate in cultured human fetal retinal pigment epithelial cells

    Hamann, S., Cour, M. L., Ming Lui, G., Bundgaard, M. & Zeuthen, Thomas, 2000, In: Pflügers Archiv: European Journal of Physiology. 440, p. 84-92

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Water transport by the renal Na(+)-dicarboxylate cotransporter.

    Meinild, A. K., Loo, D. D., Pajor, A. M., Zeuthen, Thomas & Wright, E. M., 2000, In: American Journal of Physiology - Renal Physiology. 278, 5, p. F777-83

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. 1999
  68. Published

    Commentary on "Epithelial Fluid Transport--A Century of Investigation"

    Loo, D. D. F., Wright, E. M., Meinild, A., Klaerke, D. A. & Zeuthen, Thomas, 1999, In: Physiology. 14, 3, p. 98-100 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Passive water and ion transport by cotransporters.

    Loo, D. D., Hirayama, B. A., Meinild, A. K., Chandy, G., Zeuthen, Thomas & Wright, E. M., 1999, In: Journal of Physiology. 518, 1, p. 195-202 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. 1998
  71. Published

    Aquaporins in complex tissues: Distribution of aquaporins 1-5 in human and rat eye

    Hamann, Steffen, Zeuthen, Thomas, la Cour, Morten, Nagelhus, E., Ottersen, O. P., Agre, P. & Nielsen, S., 1998, In: American Journal of Physiology: Cell Physiology. 274, 5, p. C1332-C1345

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.

    Meinild, A. K., Klærke, Dan Arne & Zeuthen, Thomas, 1998, In: Journal of Biological Chemistry. 273, 49, p. 32446-51 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    The human Na+-glucose cotransporter is a molecular water pump.

    Meinild, A., Klærke, Dan Arne, Loo, D. D., Wright, E. M. & Zeuthen, Thomas, 1998, In: Journal of Physiology. 508 ( Pt 1), p. 15-21 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. 1997
  75. Published

    ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines

    Litman, Thomas, Nielsen, D., Skovsgaard, T., Zeuthen, Thomas & Stein, W. D., 1997, In: BBA General Subjects. 1361, 2, p. 147-158

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

    Litman, Thomas, Zeuthen, Thomas, Skovsgaard, T. & Stein, W. D., 1997, In: BBA General Subjects. vol. 1361, p. 169-176

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

    Litman, Thomas, Zeuthen, Thomas, Skovsgaard, T. & Stein, W. D., 1997, In: BBA General Subjects. 1361, 2, p. 159-168

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Water transport by the Na+/glucose cotransporter under isotonic conditions

    Zeuthen, Thomas, Meinild, A. K., Klaerke, D. A., Loo, D. D., Wright, E. M., Belhage, B. & Litman, Thomas, 1997, In: Biology of the Cell. 89, 5-6, p. 307-12 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. 1996
  80. Published

    Cotransport of water by the Na+/glucose cotransporter

    Loo, D. D. F., Zeuthen, Thomas, Chandy, G. & Wright, E. M., 1996, In: Proceedings of the National Academy of Science of the United States of America. 93, 23, p. 13367-13370

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Molecular Mechanisms of Water Transport

    Zeuthen, Thomas, 1996, Austen, Texas: R.G. Landes Compagny. 170 p.

    Research output: Book/ReportBookResearch

ID: 7552