Kenneth Lindegaard Madsen

Kenneth Lindegaard Madsen

Associate Professor - Promotion Programme

ORCID: 0000-0001-9274-6691

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1 - 25 out of 51Page size: 25
  1. 2024
  2. Published

    Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment

    Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Apuschkin, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, Madsen, Kenneth Lindegaard & Clemmensen, Christoffer, 2024, In: Science Advances. 10, 9, 20 p., eadg2636.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2023
  4. Published

    Behavioral encoding across timescales by region-specific dopamine dynamics

    Jørgensen, Søren Heide, Ejdrup, Aske Lykke, Lycas, M. D., Posselt, Leonie Pauline, Madsen, Kenneth Lindegaard, Tian, L., Dreyer, J. K., Herborg, Freja, Sørensen, Andreas Toft & Gether, Ulrik, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, 10 p., e2215230120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils

    Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity

    Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2022
  8. Published

    A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data

    Ejdrup, Aske Lykke, Lycas, M. D., Lorenzen, N., Konomi Pilkati, Ainoa, Herborg, Freja, Madsen, Kenneth Lindegaard & Gether, Ulrik, 2022, In: Nature Communications. 13, 1, 4388.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    A mechanistic overview of approaches for the treatment of psychostimulant dependence

    Jensen, Kathrine Louise, Jensen, S. B. & Madsen, Kenneth Lindegaard, 2022, In: Frontiers in Pharmacology. 13, 22 p., 854176.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

    Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

    Andersen, R. C., Schmidt, J. H., Rombach, J., Lycas, M. D., Christensen, N. R., Lund, V. K., Stapleton, D. S., Pedersen, S. S., Olsen, M. A., Stoklund, M., Noes-Holt, G., Nielsen, T. T. E., Keller, M. P., Jansen, A. M., Herlo, R., Pietropaolo, M., Simonsen, J. B., Kjærulff, O., Holst, B., Attie, A. D. & 2 others, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2022, In: Journal of Clinical Investigation. 132, 5, e144904.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The Scaffold Protein PICK1 as a Target in Chronic Pain

    Sørensen, Andreas Toft, Rombach, Joscha, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2022, In: Cells. 11, 8, 1255.

    Research output: Contribution to journal › Review › Research › peer-review

  13. 2021
  14. Published

    A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain

    Jensen, Kathrine Louise, Noes-Holt, Gith, Sørensen, Andreas Toft & Madsen, Kenneth Lindegaard, 2021, In: Frontiers in Cellular Neuroscience. 15, 13 p., 750902.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2020
  16. Published

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats

    Turner, C., De Luca, M., Wolfheimer, J., Hernandez, N., Madsen, Kenneth Lindegaard & Schmidt, H. D., 2020, In: Neuropharmacology. 164, 107901.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Constitutive internalization across therapeutically targeted GPCRs correlates with constitutive activity

    Schmidt, Jan Hendrik, Perslev, Mathias, Bukowski, L., Stoklund, M., Herborg, Freja, Herlo, R. & Madsen, Kenneth Lindegaard, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 116-121 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2019
  20. Published

    Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species

    Skamris, T., Marasini, C., Madsen, Kenneth Lindegaard, Foderà, Vito & Vestergaard, Bente, 2019, In: Scientific Reports. 9, p. 1-11 11 p., 1733.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins

    Kasaragod, V. B., Hausrat, T. J., Schaefer, N., Kuhn, M., Christensen, N. R., Tessmer, I., Maric, H. M., Madsen, Kenneth Lindegaard, Sotriffer, C., Villmann, C., Kneussel, M. & Schindelin, H., 2019, In: Neuron. 101, 4, p. 673-689 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Supported Cell Membrane Sheets to Monitor Protein Assembly

    qrc243, qrc243, Thorsen, T. S. & Madsen, Kenneth Lindegaard, 2019, In: Bio-protocol. 9, 18

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2018
  25. Published

    Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes

    Lund, Viktor Karlovich, Madsen, Kenneth Lindegaard & Kjærulff, Ole, 2018, In: Autophagy. 14, 9, p. 1520-1542 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

    Jensen, Rasmus Herlo Beenfeldt, Lund, Viktor Karlovich, Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., qrc243, qrc243, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

    Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. 2017
  29. Published

    Striatal neurons get a kick out of dopamine

    Madsen, Kenneth Lindegaard & Dreyer, J. K., Dec 2017, In: Journal of Physiology. 595, 24, p. 7271-7272 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes

    Falk-Petersen, C. B., Søgaard, R., Madsen, Kenneth Lindegaard, Klein, A. B., Frølund, Bente & Wellendorph, Petrine, Aug 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 2, p. 119-129 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Recursive Alterations of the Relationship between Simple Membrane Geometry and Insertion of Amphiphilic Motifs

    Madsen, Kenneth Lindegaard & Jensen, Rasmus Herlo Beenfeldt, 2017, In: Membranes. 7, 1, 19 p., 7010006.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway

    Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2016
  34. Published

    Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini

    Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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