Jens D. Mikkelsen

Jens D. Mikkelsen

Professor


  1. 2023
  2. Published

    Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation

    Burmester, D. R., Madsen, M. K., Szabo, A., trj450, trj450, Stenbæk, Dea Siggaard, Frøkjær, Vibe Gedsø, Elfving, B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Fisher, Patrick Mac Donald, 2023, In: Comprehensive Psychoneuroendocrinology. 13, 7 p., 100163.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

    Mikkelsen, Jens D., Kaad, S., trj450, trj450 & Finsen, Bente, 2023, In: Neurobiology of Aging. 129, p. 50-57 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke

    Thougaard, E., Nielsen, P. V., Forsberg, A., Phuong, V., Velasco, A. M., Wlodarczyk, A., Wajant, H., Lang, I., Mikkelsen, Jens D., Clausen, B. H., Brambilla, R. & Lambertsen, K. L., 2023, In: Journal of Neuroimmunology. 385, 17 p., 578246.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published
  6. 2022
  7. Published

    Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells

    trj450, trj450 & Mikkelsen, Jens D., 2022, In: Neuroimmunomodulation. 27, 4, p. 194-202 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

    Pazarlar, B. A., trj450, trj450, Petukhov, V., Pinborg, Lars Hageman, Khodosevich, Konstantin & Mikkelsen, Jens D., 2022, In: Molecular Brain. 15, 1, 45.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain

    Mikkelsen, Jens D., trj450, trj450, Bascuñana, P., Bankstahl, M., Bankstahl, J. P. & Pazarlar, B. A., 2022, In: Neuroscience. 499, p. 142-151 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

    Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, Jens D. & Hansen, J. B., 2022, In: Experimental Neurology. 358, 12 p., 114209.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study

    Pazarlar, B. A., Madsen, C. A., Oyar, E. Ö., Eğilmez, C. B. & Mikkelsen, Jens D., 2022, In: Epilepsy Research. 183, 10 p., 106926.

    Research output: Contribution to journalJournal articlepeer-review

  12. 2021
  13. Published

    Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion

    Aripaka, S. S., jmn329, jmn329, Jørgensen, Louise Møller, Chughtai, S. A., Gaarde, C., Bendix, T. & Mikkelsen, Jens D., 2021, In: European Spine Journal. 30, p. 2967–2974 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    N1H- and N1-Substituted Phenylguanidines as alpha 7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies

    Alwassil, O., Khatri, S., Schulte, M. K., Aripaka, S. S., Mikkelsen, Jens D. & Dukat, M., 2021, In: ACS Chemical Neuroscience. 12, 12, p. 2194-2201 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

    Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, Ida Vang, Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, Jens D., Fisher, P. M. D., Herth, Matthias Manfred, Plavén-Sigray, P., Knudsen, Gitte Moos & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

    Research output: Contribution to journalJournal articlepeer-review

  16. 2020
  17. Published

    In vitro and in vivo characterization of dibenzothiophene derivatives [125I]iodo-ASEM and [18F]ASEM as radiotracers of homo- And heteromeric α7 nicotinic acetylcholine receptors

    Donat, C. K., Hansen, H. H., Hansen, H. D., Mease, R. C., Horti, A. G., Pomper, M. G., L’Estrade, E. T., Herth, Matthias Manfred, Peters, D., Knudsen, Gitte Moos & Mikkelsen, Jens D., 1 Jan 2020, In: Molecules. 25, 6, 19 p., 1425.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis: [incl. Author Correction]

    Pfisterer, U., Petukhov, V., Demharter, S., Meichsner, J., Thompson, J. J., Batiuk, M. Y., Martinez, A. A., Vasistha, Navneet A, Thakur, A., Mikkelsen, Jens D., Adorjan, I., Pinborg, Lars Hageman, Pers, Tune H, von Engelhardt, J., Kharchenko, P. V. & Khodosevich, K., 2020, In: Nature Communications. 11, 1, 19 p., 5038.

    Research output: Contribution to journalJournal articlepeer-review

  19. 2019
  20. Published

    DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

    Dyrvig, M., Mikkelsen, Jens D. & Lichota, J., Jun 2019, In: Neuroscience Letters. 704, p. 145-152

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons

    Larsen, H. M., Hansen, S. K., Mikkelsen, Jens D., Hyttel, P. & Stummann, T. C., 2019, In: Stem Cell Research. 41, 10 p., 101642.

    Research output: Contribution to journalJournal articlepeer-review

  22. 2018
  23. Published

    Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus)

    Medger, K., Bennett, N. C., Chimimba, C. T., Oosthuizen, M. K., Mikkelsen, Jens D. & Coen, C. W., 2018, In: The Journal of Comparative Neurology. 526, 15, p. 2388-2405

    Research output: Contribution to journalJournal articlepeer-review

  24. Published
  25. 2017
  26. Published

    The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

    Jennings, K. J., Chasles, M., Cho, H., Mikkelsen, Jens D., Bentley, G., Keller, M. & Kriegsfeld, L. J., Nov 2017, In: Integrative and Comparative Biology. 57, 5, p. 1055-1065 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

    Wichern, F., Jensen, M. M., Christensen, D. Z., Mikkelsen, Jens D., Gondré-Lewis, M. C. & Thomsen, M. S., 27 Mar 2017, In: Neuroscience. 346, p. 278-283 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

    Hansen, H. H., Weikop, P., Mikkelsen, M. D., Rode, F. & Mikkelsen, Jens D., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 120, 1, p. 46-51 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 2017, In: Endocrinology. 158, 3, p. 652-663

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging: A test-retest study

    Feng, L., Jensen, P., Thomsen, G., Dyssegaard, A., Svarer, C., Knudsen, L. V., Møller, Kirsten, Thomsen, C., Mikkelsen, Jens D., Guilloteau, D., Knudsen, Gitte Moos & Pinborg, Lars Hageman, 2017, In: Journal of Nuclear Medicine. 58, 6, p. 989-995 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. 2016
  33. Published

    Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

    Bortz, D. M., Upton, B. A., Mikkelsen, Jens D. & Bruno, J. P., Dec 2016, In: Neuropharmacology. 111, p. 78-91

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Quantification of the functional expression of the Ca2+‐activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

    Blomster, L. V., Strøbaek, D., Hougaard, Charlotte Ørsted, Klein, J., Pinborg, Lars Hageman, Mikkelsen, Jens D. & Christophersen, P., Dec 2016, In: Glia. 64, 12, p. 2065-2078 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

    Hervig, M. E., Thomsen, M. S., Kalló, I. & Mikkelsen, Jens D., 15 Oct 2016, In: Neuroscience. 334, p. 13-25 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

    Thomsen, M. S., Arvaniti, M., Jensen, M. M., Shulepko, M. A., Dolgikh, D. A., Pinborg, Lars Hageman, Härtig, W., Lyukmanova, E. N. & Mikkelsen, Jens D., Oct 2016, In: Neurobiology of Aging. 46, p. 13-21 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

    Hansen, H. H., Fabricius, K., Barkholt, P., Mikkelsen, Jens D., Jelsing, J., Pyke, C., Knudsen, L. B. & Vrang, N., 1 Sep 2016, In: Brain Research. 1646, p. 354-365 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Functional interaction between Lypd6 and nicotinic acetylcholine receptors

    Arvaniti, M., Jensen, M. M., Soni, N., Wang, H., Klein, A. B., Thiriet, N., Pinborg, Lars Hageman, Muldoon, P. P., Wienecke, Jacob, Imad Damaj, M., Kohlmeier, Kristi Anne, Gondré-Lewis, M. C., Mikkelsen, Jens D. & Thomsen, M. S., Sep 2016, In: Journal of Neurochemistry. 138, 6, p. 806-820 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

    Wu, J., Liu, Q., Tang, P., Mikkelsen, Jens D., Shen, J., Whiteaker, P. & Yakel, J. L., Jul 2016, In: Trends in Pharmacological Sciences. 37, 7, p. 562-74 13 p.

    Research output: Contribution to journalReviewpeer-review

  40. Published

    Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

    Henningsen, J. B., Poirel, V., Mikkelsen, Jens D., Tsutsui, K., Simonneaux, V. & Gauer, F., 15 Jun 2016, In: Journal of Comparative Neurology. 524, 9, p. 1825-1838 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

    Donat, C. K., Gaber, K., Meixensberger, J., Brust, P., Pinborg, Lars Hageman, Hansen, H. H. & Mikkelsen, Jens D., Jun 2016, In: NeuroMolecular Medicine. 18, 2, p. 158-69 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    Jorgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, Jens D., Fink-Jensen, Anders, Knudsen, G. M., Paulson, Olaf B., Bolwig, T. G. & Jørgensen, Martin Balslev, Feb 2016, In: Acta Psychiatrica Scandinavica. 133, 2, p. 154-164 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice

    Salaga, M., Blomster, L. V., Piechota-Polańczyk, A., Zielińska, M., Jacenik, D., Cygankiewicz, A. I., Krajewska, W. M., Mikkelsen, Jens D. & Fichna, J., Jan 2016, In: Journal of Pharmacology and Experimental Therapeutics. 356, 1, p. 157-69 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

    Lyukmanova, E. N., Shulepko, M. A., Kudryavtsev, D., Bychkov, M. L., Kulbatskii, D. S., Kasheverov, I. E., Astapova, M. V., Feofanov, A. V., Thomsen, M. S., Mikkelsen, Jens D., Shenkarev, Z. O., Tsetlin, V. I., Dolgikh, D. A. & Kirpichnikov, M. P., 2016, In: PLOS ONE. 11, 2, p. 1-14 14 p., e0149733.

    Research output: Contribution to journalJournal articlepeer-review

  45. 2015
  46. Published

    Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study

    Bertelsen, B., Oranje, B., Melchior, L., Fagerlund, Birgitte, Werge, Thomas, Mikkelsen, Jens D., Tümer, Asuman Zeynep & Glenthøj, Birte Yding, Dec 2015, In: NeuroMolecular Medicine. 17, 4, p. 423-30 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

    Frokjaer, V. G., Pinborg, Anja, Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., Stenbæk, D. S., da Cunha-Bang, S., Lehel, S., Siebner, Hartwig Roman, Mikkelsen, Jens D., Svarer, C. & Knudsen, Gitte Moos, 15 Oct 2015, In: Biological Psychiatry. 78, 8, p. 534-43 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

    Magnussen, J. H., Ettrup, A., Donat, C. K., Peters, D., Pedersen, M. H. F., Knudsen, G. M. & Mikkelsen, Jens D., 5 Sep 2015, In: European Journal of Pharmacology. 762, p. 35-41 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

    Jensen, P., Feng, L., Law, Ian, Svarer, C., Knudsen, G. M., Mikkelsen, Jens D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D. & Pinborg, Lars Hageman, Sep 2015, In: Journal of Nuclear Medicine. 56, 9, p. 1386-90 5 p.

    Research output: Contribution to journalComment/debatepeer-review

  50. Published

    Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease

    Jensen, M. M., Mikkelsen, Jens D., Arvaniti, M., Pinborg, Lars Hageman & Thomsen, M. S., 1 Apr 2015, In: Neurobiology of Aging. 36, 4, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats

    Overgaard, A., Axel, A. M., Lie, M. E., Hansen, H. H. & Mikkelsen, Jens D., Apr 2015, In: Endocrine Regulations. 49, 2, p. 51-7 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels

    Fisher, Patrick Mac Donald, Holst, K. K., Adamsen, D., Klein, A. B., Frøkjær, Vibe Gedsø, Jensen, P. S., Svarer, C., Gillings, N., Baare, W. F. C., Mikkelsen, Jens D. & Knudsen, G. M., Jan 2015, In: Human Brain Mapping. 36, 1, p. 313–323 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats

    Frimer, N. A., Overgaard, A., Lie, M. E. K., Mikkelsen, Jens D. & Frokjaer, V. G., 2015, In: Journal of Steroids & Hormonal Science. 6, 3, p. 1-5 5 p., 1000161.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

    Thomsen, M. S., Zwart, R., Ursu, D., Jensen, M. M., Pinborg, Lars Hageman, Gilmour, G., Wu, J., Sher, E. & Mikkelsen, Jens D., 2015, In: PLOS ONE. 10, 6, p. 1-16 16 p., e0130572.

    Research output: Contribution to journalJournal articlepeer-review

  55. 2014
  56. Published

    Association of the CHRNA7 promoter variant −86T with Tourette syndrome and comorbid obsessive-compulsive disorder

    Bertelsen, B., Melchior, L., Tümer, Asuman Zeynep, Groth, C., Mol Debes, N., Skov, L., Holst, K. K., Fagerlund, Birgitte & Mikkelsen, Jens D., 30 Nov 2014, In: Psychiatry Research. 219, 3, p. 710-711 2 p.

    Research output: Contribution to journalComment/debatepeer-review

  57. Published

    Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

    Brindisi, M., Butini, S., Franceschini, S., Brogi, S., Trotta, F., Ros, S., Cagnotto, A., Salmona, M., Casagni, A., Andreassi, M., Saponara, S., Gorelli, B., Weikop, P., Mikkelsen, Jens D., Scheel-Kruger, J., Sandager-Nielsen, K., Novellino, E., Campiani, G. & Gemma, S., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9578-9597 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated

    Thomsen, M. S., Cinar, B., Jensen, M. M., Lyukmanova, E. N., Shulepko, M. A., Tsetlin, V., Klein, A. B. & Mikkelsen, Jens D., 17 Nov 2014, In: Brain Structure and Function (Print Edition). 219, 6, p. 1923-1934 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle

    Jørgensen, S. R., Andersen, M. D., Overgaard, A. & Mikkelsen, Jens D., Nov 2014, In: Endocrinology. 155, 11, p. 4402-4410 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood

    Bortz, D. M., Jørgensen, C. V., Mikkelsen, Jens D. & Bruno, J. P., Sep 2014, In: Neuropharmacology. 84, p. 19-30 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Photoperiodic Co-Regulation of Kisspeptin, Neurokinin B and Dynorphin in the Hypothalamus of a Seasonal Rodent

    Bartzen-Sprauer, J., Klosen, P., Ciofi, P., Mikkelsen, Jens D. & Simonneaux, V., Aug 2014, In: Journal of Neuroendocrinology. 26, 8, p. 510-520 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains

    Klein, A. B., Ultved, L., Adamsen, D., Santini, M. A., Tobeña, A., Fernandez-Teruel, A., Flores, P., Moreno, M., Cardona, D., Knudsen, Gitte Moos, Aznar, S. & Mikkelsen, Jens D., 28 Mar 2014, In: Neuroscience. 263, p. 36-45 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI

    Santini, M. A., Balu, D. T., Puhl, M. D., Hill-Smith, T. E., Berg, A. R., Lucki, I., Mikkelsen, Jens D. & Coyle, J. T., 1 Feb 2014, In: Behavioural Brain Research. 259, p. 242-246 5 p.

    Research output: Contribution to journalComment/debatepeer-review

  64. Published

    Disparate Changes in Kisspeptin and Neurokinin B Expression in the Arcuate Nucleus After Sex Steroid Manipulation Reveal Differential Regulation of the Two KNDy Peptides in Rats

    Overgaard, A., Ruiz-Pino, F., Castellano, J. M., Tena-Sempere, M. & Mikkelsen, Jens D., 2014, In: Endocrinology. 155, 10, p. 3945-3955 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. 2013
  66. Published

    Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice

    Jørgensen, C. V., Jacobsen, J. P., Caron, M. G., Klein, A. B., Knudsen, Gitte Moos & Mikkelsen, Jens D., 25 Oct 2013, In: Neuroscience Letters. 555, p. 118-22 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

    Christensen, D. Z., Thomsen, M. S. & Mikkelsen, Jens D., Jul 2013, In: Neurochemistry International. 63, 1, p. 54-60 7 p.

    Research output: Contribution to journalJournal article

  68. Published

    Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

    Klein, A. B., Jennum, Poul, Knudsen, S., Gammeltoft, S. & Mikkelsen, Jens D., 7 Jun 2013, In: Neuroscience Letters. 544, p. 31-35 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia

    Santini, M. A., Ratner, C. F., Aznar, S., Klein, A. B., Knudsen, Gitte Moos, Mikkelsen, Jens D. & Klein, A. B., May 2013, In: Journal of Neuroscience Research. 91, 5, p. 634-41 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice

    Overgaard, A., Tena-Sempere, M., Franceschini, I., Desroziers, E., Simonneaux, V. & Mikkelsen, Jens D., 2013, In: Peptides. 45, p. 85-90 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Distribution and seasonal variation in hypothalamic RF-amide peptides in a semi-desert rodent, the jerboa

    Janati, A., Talbi, R., Klosen, P., Mikkelsen, Jens D., Magoul, R., Simonneaux, V. & El Ouezzani, S., 2013, In: Journal of Neuroendocrinology. 25, 4, p. 402-411 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    Effect of a postnatal high-fat diet exposure on puberty onset, estrous cycle regularity, and kisspeptin expression in female rats

    Lie, M. E. K., Overgaard, A. & Mikkelsen, Jens D., 2013, In: Reproductive Biology. 13, 4, p. 298-308 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus)

    Piekarski, D. J., Zhao, S., Jennings, K. J., Iwasa, T., Legan, S. J., Mikkelsen, Jens D., Tsutsui, K. & Kriegsfeld, L. J., 2013, In: Hormones and Behavior. 64, 3, p. 501-510 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. Localized infusions of the partial alpha 7 nicotinic receptor agonist SSR180711 evoke rapid and transient increases in prefrontal glutamate release

    Bortz, D. M., Mikkelsen, Jens D. & Bruno, J. P., 2013, In: Neuroscience. 255, p. 55-67

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons

    Jørgensen, C. V., Klein, A. B., El-Sayed, M., Knudsen, G. M. & Mikkelsen, Jens D., 2013, In: Synapse. 67, 11, p. 794-800

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Microduplication of 15q13.3 and Xq21.31 in a family with tourette syndrome and comorbidities

    Melchior, L., Bertelsen, B., Debes, Nanette M Monique Mol, Groth, C., Skov, L., Mikkelsen, Jens D., Brøndum-Nielsen, K. & Tümer, Asuman Zeynep, 2013, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 162, 8, p. 825-831 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    Hansen, H. H., Jensen, M. M., Overgaard, A., Weikop, Pia & Mikkelsen, Jens D., 2013, In: Pharmacology, Biochemistry and Behavior. 110, p. 265-271 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus

    Overgaard, A., Holst, K., Mandrup, K., Boberg, J., Christiansen, S., Jacobsen, A. P., Hass, U. & Mikkelsen, Jens D., 2013, In: NeuroToxicology. 37, p. 154-162 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

    Menezes, M. M., Santini, M., Benvega, M. J., Marek, G. J., Merchant, K. M., Mikkelsen, Jens D. & Svensson, K. A., 2013, In: Neuroscience Journal. 2013, 8 p., 736439.

    Research output: Contribution to journalJournal articlepeer-review

  80. 2012
  81. Published

    The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

    Thomsen, M. S. & Mikkelsen, Jens D., 15 Oct 2012, In: Journal of Neuroimmunology. 251, 1-2, p. 65-72 8 p.

    Research output: Contribution to journalJournal article

  82. Published

    Transient inactivation of the neonatal ventral hippocampus impairs attentional set-shifting behavior: reversal with an α7 nicotinic agonist

    Brooks, J. M., Pershing, M. L., Thomsen, M. S., Mikkelsen, Jens D., Sarter, M. & Bruno, J. P., Oct 2012, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 37, 11, p. 2476-86 11 p.

    Research output: Contribution to journalJournal article

  83. Published

    Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

    Thomsen, M. S. & Mikkelsen, Jens D., Oct 2012, In: Journal of Neurochemistry. 123, 1, p. 73-83 11 p.

    Research output: Contribution to journalJournal article

  84. Published

    The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets?

    Thomsen, M. S. & Mikkelsen, Jens D., May 2012, In: Current Drug Targets. 13, 5, p. 707-20 14 p.

    Research output: Contribution to journalJournal article

  85. Published

    Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.

    Dyrvig, M., Hansen, H. H., Christiansen, S. H. O., Woldbye, David Paul Drucker, Mikkelsen, Jens D. & Lichota, J., 2012, In: Brain Research Bulletin. 88, p. 507-13 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    Reprogrammering af modne celler til neuroner

    Mikkelsen, Jens D., Rasmussen, M. A., Meyer, M. & Knudsen, G. M., 2012, In: Ugeskrift for Laeger. 174, 12, p. 786

    Research output: Contribution to journalJournal articlepeer-review

  87. 2011
  88. Published

    Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats

    Thomsen, M. S., El-Sayed, M. & Mikkelsen, Jens D., 2011, In: PLOS ONE. 6, 11, p. e27014

    Research output: Contribution to journalJournal article

  89. Published

    Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

    Thomsen, M. S., Weyn, A. & Mikkelsen, Jens D., 2011, In: Bipolar Disorders (English Edition, Online). 13, 7-8, p. 701-7 7 p.

    Research output: Contribution to journalJournal article

  90. 2010
  91. Published

    Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice

    Holm, P., Ettrup, A., Klein, A. B., Santini, M. A., El-Sayed, M., Elvang, A. B., Stensbøl, T. B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Kleijn, S. A., 1 Jan 2010, In: Journal of Alzheimer's Disease. 20, 4, p. 1201-13 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain

    Thomsen, M. S., Hay-Schmidt, Anders, Hansen, H. H. & Mikkelsen, Jens D., 2010, In: Cerebral Cortex. 20, 9, p. 2092-102 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    Distinct neural pathways mediate α7 nicotinic acetylcholine receptor-dependent activation of the forebrain

    Thomsen, M. S., Hay-Schmidt, Anders, Hansen, H. H. & Mikkelsen, Jens D., 2010, In: Cerebral Cortex. 20, 9, p. 2092-102

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

    Larsen, M. H., Mikkelsen, Jens D., Hay-Schmidt, Anders & Sandi, C., 2010, In: Journal of Psychiatric Research.

    Research output: Contribution to journalJournal articlepeer-review

  95. 2009
  96. Published

    BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures

    Trajkovska, V., Santini, M. A., Marcussen, A. B., Thomsen, M. S., Hansen, H. H., Mikkelsen, Jens D., Arneberg, L., Kokaia, M., Knudsen, G. M. & Aznar, S., 2009, In: Neurochemistry International. 55, 7, p. 697-702 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus

    Bendová, Z., Sumová, A. & Mikkelsen, Jens D., 2009, In: Neuroscience. 159, 2, p. 599-609 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

    Butini, S., Gemma, S., Campiani, G., Franceschini, S., Trotta, F., Borriello, M., Ceres, N., Ros, S., Coccone, S. S., Bernetti, M., De Angelis, M., Brindisi, M., Nacci, V., Fiorini, I., Novellino, E., Cagnotto, A., Mennini, T., Sandager-Nielsen, K., Andreasen, J. T., Scheel-Kruger, J. & 2 others, Mikkelsen, Jens D. & Fattorusso, C., 2009, In: Journal of Medicinal Chemistry. 52, 1, p. 151-69 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    Melatonin controls seasonal breeding by a network of hypothalamic targets

    Revel, F. G., Masson-Pévet, M., Pévet, P., Mikkelsen, Jens D. & Simonneaux, V., 2009, In: Neuroendocrinology. 90, 1, p. 1-14 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  100. Published

    Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

    Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, Jens D. & Mirza, N. R., 2009, In: Neuroscience. 163, 1, p. 73-81 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment

    Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P. & Mikkelsen, Jens D., 2009, In: Neuropharmacology. 56, 6-7, p. 1001-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. 2008
  103. Published

    The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42

    Søderman, A., Thomsen, M. S., Hansen, H. H., Nielsen, E. Ø., Jensen, M. S., West, M. J. & Mikkelsen, Jens D., 28 Aug 2008, In: Brain Research. 1227, p. 240-7 8 p.

    Research output: Contribution to journalJournal article

  104. Published

    The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat

    Thomsen, M. S., Mikkelsen, Jens D., Timmermann, D. B., Peters, D. A., Hay-Schmidt, Anders, Martens, H. A., Hansen, H. H. & Thomsen, M. S., 23 Jun 2008, In: Neuroscience. 154, 2, p. 741-53 13 p.

    Research output: Contribution to journalJournal article

  105. Published

    Kisspeptin and the seasonal control of reproduction in hamsters

    Simonneaux, V., Ansel, L., Revel, F. G., Klosen, P., Pévet, P. & Mikkelsen, Jens D., 2008, In: Peptides. 30, 1, p. 146-53 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats

    Bundzikova, J., Pirnik, Z., Zelena, D., Kiss, A. & Mikkelsen, Jens D., 2008, In: Cellular & Molecular Neurobiology. 28, 8, p. 1033-1047 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. Published

    The neuroanatomy of the kisspeptin system in the mammalian brain

    Mikkelsen, Jens D. & Simonneaux, V., 2008, In: Peptides. 30, 1, p. 26-33 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  108. 2007
  109. Published

    The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat

    Kristensen, S., Thomsen, M. S., Hansen, H. H., Timmermann, D. B., Hay-Schmidt, Anders & Mikkelsen, Jens D., 17 May 2007, In: Neuroscience Letters. 418, 2, p. 154-8 5 p.

    Research output: Contribution to journalJournal article

  110. 2005
  111. Published

    Modulation of anxiety circuits by serotonergic systems

    Lowry, C. A., Johnson, P. L., Hay-Schmidt, Anders, Mikkelsen, Jens D. & Shekhar, A., Dec 2005, In: Stress: The International Journal on the Biology of Stress . 8, 4, p. 233-246 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  112. Published

    Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs

    Abrams, J. K., Johnson, P. L., Hay-Schmidt, Anders, Mikkelsen, Jens D., Shekhar, A. & Lowry, C. A., 2005, In: Neuroscience. 133, 4, p. 983-97 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  113. 2004
  114. Published

    Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors

    Mikkelsen, Jens D., Hay-Schmidt, Anders & Kiss, A., Jun 2004, In: Annals of the New York Academy of Sciences. 1018, p. 65-70 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  115. 2001
  116. Published

    Hypocretin (orexin) in the rat pineal gland: A central transmitter with effects on noradrenaline-induced release of melatonin

    Mikkelsen, Jens D., Hauser, Frank, DeLecea, L., Sutcliffe, J. G., Kilduff, T. S., Calgari, C., Pévet, P. & Simonneaux, V., 2001, In: European Journal of Neuroscience. 14, 3, p. 419-425 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  117. 1999
  118. Published

    Developmental expression of α-synuclein in rat hippocampus and cerebral cortex

    Petersen, K., Olesen, Ole Frilev & Mikkelsen, Jens D., Jun 1999, In: Neuroscience. 91, 2, p. 651-659 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  119. Published

    Neuropeptide Y (NPY) and NPY receptors in the rat pineal gland

    Mikkelsen, Jens D., Hauser, Frank & Olcese, J., 1999, In: Advances in Experimental Medicine and Biology. 460, p. 95-107 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  120. 1998
  121. Published

    Amyloid β neurotoxicity in the cholinergic but not in the serotonergic phenotype of RN46A cells

    Olesen, Ole Frilev, Dagø, L. & Mikkelsen, Jens D., 15 Jun 1998, In: Molecular Brain Research. 57, 2, p. 266-274 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  122. Published

    Aβ Induces Cell Death in Pc12 Cells and Tau-Transfected Cho Cells, but only Tau Phosphorylation in Pc12 Cells

    Fjord-Larsen, L., Mikkelsen, Jens D. & Olesen, Ole Frilev, 1998, Progress in Alzheimer’s and Parkinson’s Diseases . p. 257-263 7 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  123. Published

    The Cholinergic but not the Serotonergic Phenotype of Anew Neuronal Cell Line is Sensitive to β-Amyloid-Induced Toxicity

    Olesen, Ole Frilev, Fjord-Larsen, L. & Mikkelsen, Jens D., 1998, Progress in Alzheimer’s and Parkinson’s Diseases . p. 495-501 7 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  124. 1997
  125. Published

    Isoform-specific binding of human apolipoprotein E to the non-amyloid β component of Alzheimer's disease amyloid

    Olesen, Ole Frilev, Mikkelsen, Jens D., Gerdes, C. & Jensen, P. H., Feb 1997, In: Molecular Brain Research. 44, 1, p. 105-112 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  126. 1994
  127. Published

    Induced resistance in sugar beet against Cercospora beticola: Induction by dichloroisonicotinic acid is independent of chitinase and β-1,3-glucanase transcript accumulation

    Nielsen, K. K., Bojsen, K., Collinge, David B. & Mikkelsen, Jens D., 1 Jan 1994, In: Physiological and Molecular Plant Pathology. 45, 2, p. 89-99 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  128. Published

    Efferent connections from the lateral hypothalamic region and the lateral preoptic area to the hypothalamic paraventricular nucleus of the rat

    Larsen, P. J., Hay-Schmidt, Anders & Mikkelsen, Jens D., 1994, In: Journal of Comparative Neurology. 342, 2, p. 299-319 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  129. 1991
  130. Published

    Induction, purification and characterization of chitinase isolated from pea leaves inoculated with Ascochyta pisi

    Vad, K., Mikkelsen, Jens D. & Collinge, David B., 1 Apr 1991, In: Planta. 184, 1, p. 24-29 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  131. 1988
  132. Published

    Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

    Raaberg, L., Nexo, E., Mikkelsen, Jens D. & Poulsen, Steen Seier, 1 Jul 1988, In: Histochemistry. 89, 4, p. 351-356 6 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 32177473