Jens D. Mikkelsen

Jens D. Mikkelsen

Professor


  1. 2023
  2. Published

    Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation

    Burmester, D. R., Madsen, M. K., Szabo, A., trj450, trj450, Stenbæk, Dea Siggaard, Frøkjær, Vibe Gedsø, Elfving, B., Mikkelsen, Jens D., Knudsen, Gitte Moos & Fisher, Patrick Mac Donald, 2023, In: Comprehensive Psychoneuroendocrinology. 13, 7 p., 100163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

    Mikkelsen, Jens D., Kaad, S., trj450, trj450 & Finsen, Bente, 2023, In: Neurobiology of Aging. 129, p. 50-57 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke

    Thougaard, E., Nielsen, P. V., Forsberg, A., Phuong, V., Velasco, A. M., Wlodarczyk, A., Wajant, H., Lang, I., Mikkelsen, Jens D., Clausen, B. H., Brambilla, R. & Lambertsen, K. L., 2023, In: Journal of Neuroimmunology. 385, 17 p., 578246.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome

    trj450, trj450, jmn329, jmn329, Jørgensen, Louise Møller & Mikkelsen, Jens D., 2023, In: Molecular and Cellular Biochemistry. 478, 1, p. 121-130 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2022
  7. Published

    Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells

    trj450, trj450 & Mikkelsen, Jens D., 2022, In: Neuroimmunomodulation. 27, 4, p. 194-202 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

    Pazarlar, B. A., trj450, trj450, Petukhov, V., Pinborg, Lars Hageman, Khodosevich, Konstantin & Mikkelsen, Jens D., 2022, In: Molecular Brain. 15, 1, 45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain

    Mikkelsen, Jens D., trj450, trj450, Bascuñana, P., Bankstahl, M., Bankstahl, J. P. & Pazarlar, B. A., 2022, In: Neuroscience. 499, p. 142-151 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

    Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, Jens D. & Hansen, J. B., 2022, In: Experimental Neurology. 358, 12 p., 114209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study

    Pazarlar, B. A., Madsen, C. A., Oyar, E. Ö., Eğilmez, C. B. & Mikkelsen, Jens D., 2022, In: Epilepsy Research. 183, 10 p., 106926.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2021
  13. Published

    Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion

    Aripaka, S. S., jmn329, jmn329, Jørgensen, Louise Møller, Chughtai, S. A., Gaarde, C., Bendix, T. & Mikkelsen, Jens D., 2021, In: European Spine Journal. 30, p. 2967–2974 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    N1H- and N1-Substituted Phenylguanidines as alpha 7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies

    Alwassil, O., Khatri, S., Schulte, M. K., Aripaka, S. S., Mikkelsen, Jens D. & Dukat, M., 2021, In: ACS Chemical Neuroscience. 12, 12, p. 2194-2201 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

    Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, Ida Vang, Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, Jens D., Fisher, P. M. D., Herth, Matthias Manfred, Plavén-Sigray, P., Knudsen, Gitte Moos & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2020
  17. Published

    In vitro and in vivo characterization of dibenzothiophene derivatives [125I]iodo-ASEM and [18F]ASEM as radiotracers of homo- And heteromeric α7 nicotinic acetylcholine receptors

    Donat, C. K., Hansen, H. H., Hansen, H. D., Mease, R. C., Horti, A. G., Pomper, M. G., L’Estrade, E. T., Herth, Matthias Manfred, Peters, D., Knudsen, Gitte Moos & Mikkelsen, Jens D., 1 Jan 2020, In: Molecules. 25, 6, 19 p., 1425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis: [incl. Author Correction]

    Pfisterer, U., Petukhov, V., Demharter, S., Meichsner, J., Thompson, J. J., Batiuk, M. Y., Martinez, A. A., Vasistha, Navneet A, Thakur, A., Mikkelsen, Jens D., Adorjan, I., Pinborg, Lars Hageman, Pers, Tune H, von Engelhardt, J., Kharchenko, P. V. & Khodosevich, K., 2020, In: Nature Communications. 11, 1, 19 p., 5038.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2019
  20. Published

    DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

    Dyrvig, M., Mikkelsen, Jens D. & Lichota, J., Jun 2019, In: Neuroscience Letters. 704, p. 145-152

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons

    Larsen, H. M., Hansen, S. K., Mikkelsen, Jens D., Hyttel, P. & Stummann, T. C., 2019, In: Stem Cell Research. 41, 10 p., 101642.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2018
  23. Published

    Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus)

    Medger, K., Bennett, N. C., Chimimba, C. T., Oosthuizen, M. K., Mikkelsen, Jens D. & Coen, C. W., 2018, In: The Journal of Comparative Neurology. 526, 15, p. 2388-2405

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. 2017
  26. Published

    The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

    Jennings, K. J., Chasles, M., Cho, H., Mikkelsen, Jens D., Bentley, G., Keller, M. & Kriegsfeld, L. J., Nov 2017, In: Integrative and Comparative Biology. 57, 5, p. 1055-1065 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

    Wichern, F., Jensen, M. M., Christensen, D. Z., Mikkelsen, Jens D., Gondré-Lewis, M. C. & Thomsen, M. S., 27 Mar 2017, In: Neuroscience. 346, p. 278-283 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

    Hansen, H. H., Weikop, P., Mikkelsen, M. D., Rode, F. & Mikkelsen, Jens D., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 120, 1, p. 46-51 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 2017, In: Endocrinology. 158, 3, p. 652-663

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging: A test-retest study

    Feng, L., Jensen, P., Thomsen, G., Dyssegaard, A., Svarer, C., Knudsen, L. V., Møller, Kirsten, Thomsen, C., Mikkelsen, Jens D., Guilloteau, D., Knudsen, Gitte Moos & Pinborg, Lars Hageman, 2017, In: Journal of Nuclear Medicine. 58, 6, p. 989-995 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2016
  33. Published

    Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

    Bortz, D. M., Upton, B. A., Mikkelsen, Jens D. & Bruno, J. P., Dec 2016, In: Neuropharmacology. 111, p. 78-91

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Quantification of the functional expression of the Ca2+‐activated K+ channel KCa3.1 on microglia from adult human neocortical tissue

    Blomster, L. V., Strøbaek, D., Hougaard, Charlotte Ørsted, Klein, J., Pinborg, Lars Hageman, Mikkelsen, Jens D. & Christophersen, P., Dec 2016, In: Glia. 64, 12, p. 2065-2078 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

    Hervig, M. E., Thomsen, M. S., Kalló, I. & Mikkelsen, Jens D., 15 Oct 2016, In: Neuroscience. 334, p. 13-25 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

    Thomsen, M. S., Arvaniti, M., Jensen, M. M., Shulepko, M. A., Dolgikh, D. A., Pinborg, Lars Hageman, Härtig, W., Lyukmanova, E. N. & Mikkelsen, Jens D., Oct 2016, In: Neurobiology of Aging. 46, p. 13-21 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

    Hansen, H. H., Fabricius, K., Barkholt, P., Mikkelsen, Jens D., Jelsing, J., Pyke, C., Knudsen, L. B. & Vrang, N., 1 Sep 2016, In: Brain Research. 1646, p. 354-365 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Functional interaction between Lypd6 and nicotinic acetylcholine receptors

    Arvaniti, M., Jensen, M. M., Soni, N., Wang, H., Klein, A. B., Thiriet, N., Pinborg, Lars Hageman, Muldoon, P. P., Wienecke, Jacob, Imad Damaj, M., Kohlmeier, Kristi Anne, Gondré-Lewis, M. C., Mikkelsen, Jens D. & Thomsen, M. S., Sep 2016, In: Journal of Neurochemistry. 138, 6, p. 806-820 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

    Wu, J., Liu, Q., Tang, P., Mikkelsen, Jens D., Shen, J., Whiteaker, P. & Yakel, J. L., Jul 2016, In: Trends in Pharmacological Sciences. 37, 7, p. 562-74 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

    Henningsen, J. B., Poirel, V., Mikkelsen, Jens D., Tsutsui, K., Simonneaux, V. & Gauer, F., 15 Jun 2016, In: Journal of Comparative Neurology. 524, 9, p. 1825-1838 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

    Donat, C. K., Gaber, K., Meixensberger, J., Brust, P., Pinborg, Lars Hageman, Hansen, H. H. & Mikkelsen, Jens D., Jun 2016, In: NeuroMolecular Medicine. 18, 2, p. 158-69 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    Jorgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, Jens D., Fink-Jensen, Anders, Knudsen, G. M., Paulson, Olaf B., Bolwig, T. G. & Jørgensen, Martin Balslev, Feb 2016, In: Acta Psychiatrica Scandinavica. 133, 2, p. 154-164 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice

    Salaga, M., Blomster, L. V., Piechota-Polańczyk, A., Zielińska, M., Jacenik, D., Cygankiewicz, A. I., Krajewska, W. M., Mikkelsen, Jens D. & Fichna, J., Jan 2016, In: Journal of Pharmacology and Experimental Therapeutics. 356, 1, p. 157-69 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

    Lyukmanova, E. N., Shulepko, M. A., Kudryavtsev, D., Bychkov, M. L., Kulbatskii, D. S., Kasheverov, I. E., Astapova, M. V., Feofanov, A. V., Thomsen, M. S., Mikkelsen, Jens D., Shenkarev, Z. O., Tsetlin, V. I., Dolgikh, D. A. & Kirpichnikov, M. P., 2016, In: PLOS ONE. 11, 2, p. 1-14 14 p., e0149733.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2015
  46. Published

    Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study

    Bertelsen, B., Oranje, B., Melchior, L., Fagerlund, Birgitte, Werge, Thomas, Mikkelsen, Jens D., Tümer, Asuman Zeynep & Glenthøj, Birte Yding, Dec 2015, In: NeuroMolecular Medicine. 17, 4, p. 423-30 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

    Frokjaer, V. G., Pinborg, Anja, Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., Stenbæk, D. S., da Cunha-Bang, S., Lehel, S., Siebner, Hartwig Roman, Mikkelsen, Jens D., Svarer, C. & Knudsen, Gitte Moos, 15 Oct 2015, In: Biological Psychiatry. 78, 8, p. 534-43 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

    Magnussen, J. H., Ettrup, A., Donat, C. K., Peters, D., Pedersen, M. H. F., Knudsen, G. M. & Mikkelsen, Jens D., 5 Sep 2015, In: European Journal of Pharmacology. 762, p. 35-41 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

    Jensen, P., Feng, L., Law, Ian, Svarer, C., Knudsen, G. M., Mikkelsen, Jens D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D. & Pinborg, Lars Hageman, Sep 2015, In: Journal of Nuclear Medicine. 56, 9, p. 1386-90 5 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  50. Published

    Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease

    Jensen, M. M., Mikkelsen, Jens D., Arvaniti, M., Pinborg, Lars Hageman & Thomsen, M. S., 1 Apr 2015, In: Neurobiology of Aging. 36, 4, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats

    Overgaard, A., Axel, A. M., Lie, M. E., Hansen, H. H. & Mikkelsen, Jens D., Apr 2015, In: Endocrine Regulations. 49, 2, p. 51-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels

    Fisher, Patrick Mac Donald, Holst, K. K., Adamsen, D., Klein, A. B., Frøkjær, Vibe Gedsø, Jensen, P. S., Svarer, C., Gillings, N., Baare, W. F. C., Mikkelsen, Jens D. & Knudsen, G. M., Jan 2015, In: Human Brain Mapping. 36, 1, p. 313–323 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats

    Frimer, N. A., Overgaard, A., Lie, M. E. K., Mikkelsen, Jens D. & Frokjaer, V. G., 2015, In: Journal of Steroids & Hormonal Science. 6, 3, p. 1-5 5 p., 1000161.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

    Thomsen, M. S., Zwart, R., Ursu, D., Jensen, M. M., Pinborg, Lars Hageman, Gilmour, G., Wu, J., Sher, E. & Mikkelsen, Jens D., 2015, In: PLOS ONE. 10, 6, p. 1-16 16 p., e0130572.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2014
  56. Published

    Association of the CHRNA7 promoter variant −86T with Tourette syndrome and comorbid obsessive-compulsive disorder

    Bertelsen, B., Melchior, L., Tümer, Asuman Zeynep, Groth, C., Mol Debes, N., Skov, L., Holst, K. K., Fagerlund, Birgitte & Mikkelsen, Jens D., 30 Nov 2014, In: Psychiatry Research. 219, 3, p. 710-711 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  57. Published

    Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

    Brindisi, M., Butini, S., Franceschini, S., Brogi, S., Trotta, F., Ros, S., Cagnotto, A., Salmona, M., Casagni, A., Andreassi, M., Saponara, S., Gorelli, B., Weikop, P., Mikkelsen, Jens D., Scheel-Kruger, J., Sandager-Nielsen, K., Novellino, E., Campiani, G. & Gemma, S., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9578-9597 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated

    Thomsen, M. S., Cinar, B., Jensen, M. M., Lyukmanova, E. N., Shulepko, M. A., Tsetlin, V., Klein, A. B. & Mikkelsen, Jens D., 17 Nov 2014, In: Brain Structure and Function (Print Edition). 219, 6, p. 1923-1934 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle

    Jørgensen, S. R., Andersen, M. D., Overgaard, A. & Mikkelsen, Jens D., Nov 2014, In: Endocrinology. 155, 11, p. 4402-4410 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood

    Bortz, D. M., Jørgensen, C. V., Mikkelsen, Jens D. & Bruno, J. P., Sep 2014, In: Neuropharmacology. 84, p. 19-30 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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