Anders A. Jensen
Department of Drug Design and Pharmacology, UCPH
“Molecular pharmacology of neurotransmitter receptors: Usual Suspects, Black Sheep & Notorious Off-Targets”
Abstract: The research focus of my group is on G-protein coupled receptors and pentameric ligand-gated ion channels (pLGICs). Our main objectives are to identify and develop novel ligands for these receptors, to elucidate the molecular mechanisms behind receptor function and modulation, and to probe the therapeutic potential in these receptors. In this talk I will present selected findings from recent and ongoing projects in my lab. I will give some examples of our long-standing interest in identifying novel allosteric modulators of classical pLGICs and delineation of their modes of action. I will also present recent findings into the molecular basis underlying the signaling through the Zinc-Activated Channel (ZAC), a largely overlooked and atypical member of the pLGIC superfamily. Finally, time permitting, I will tell the story of how ~15 years of collaborative basic research explorations of the 5-HT2A serotonin receptor was turned into innovation by “The Psychedelic Revolution”.