Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland

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Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland. / Rath, Martin F.

In: Journal of Pineal Research, Vol. 76, No. 3, e12950, 2024.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rath, MF 2024, 'Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland', Journal of Pineal Research, vol. 76, no. 3, e12950. https://doi.org/10.1111/jpi.12950

APA

Rath, M. F. (2024). Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland. Journal of Pineal Research, 76(3), [e12950]. https://doi.org/10.1111/jpi.12950

Vancouver

Rath MF. Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland. Journal of Pineal Research. 2024;76(3). e12950. https://doi.org/10.1111/jpi.12950

Author

Rath, Martin F. / Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland. In: Journal of Pineal Research. 2024 ; Vol. 76, No. 3.

Bibtex

@article{d29b8df7344c46e8bcbbf28d6b5e5953,
title = "Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland",
abstract = "Homeobox genes encode transcription factors that are widely known to control developmental processes. This is also the case in the pineal gland, a neuroendocrine brain structure devoted to nighttime synthesis of the hormone melatonin. Thus, in accordance with high prenatal gene expression, knockout studies have identified a specific set of homeobox genes that are essential for development of the pineal gland. However, as a special feature of the pineal gland, homeobox gene expression persists into adulthood, and gene product abundance exhibits 24 h circadian rhythms. Recent lines of evidence show that some homeobox genes even control expression of enzymes catalyzing melatonin synthesis. We here review current knowledge of homeobox genes in the rodent pineal gland and suggest a model for dual functions of homeobox gene-encoded transcription factors in developmental and circadian mature neuroendocrine function.",
keywords = "circadian rhythm, development, homeobox gene, melatonin, pineal gland",
author = "Rath, {Martin F.}",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Journal of Pineal Research published by John Wiley & Sons Ltd.",
year = "2024",
doi = "10.1111/jpi.12950",
language = "English",
volume = "76",
journal = "Journal of Pineal Research (Print)",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Homeobox gene-encoded transcription factors in development and mature circadian function of the rodent pineal gland

AU - Rath, Martin F.

N1 - Publisher Copyright: © 2024 The Authors. Journal of Pineal Research published by John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Homeobox genes encode transcription factors that are widely known to control developmental processes. This is also the case in the pineal gland, a neuroendocrine brain structure devoted to nighttime synthesis of the hormone melatonin. Thus, in accordance with high prenatal gene expression, knockout studies have identified a specific set of homeobox genes that are essential for development of the pineal gland. However, as a special feature of the pineal gland, homeobox gene expression persists into adulthood, and gene product abundance exhibits 24 h circadian rhythms. Recent lines of evidence show that some homeobox genes even control expression of enzymes catalyzing melatonin synthesis. We here review current knowledge of homeobox genes in the rodent pineal gland and suggest a model for dual functions of homeobox gene-encoded transcription factors in developmental and circadian mature neuroendocrine function.

AB - Homeobox genes encode transcription factors that are widely known to control developmental processes. This is also the case in the pineal gland, a neuroendocrine brain structure devoted to nighttime synthesis of the hormone melatonin. Thus, in accordance with high prenatal gene expression, knockout studies have identified a specific set of homeobox genes that are essential for development of the pineal gland. However, as a special feature of the pineal gland, homeobox gene expression persists into adulthood, and gene product abundance exhibits 24 h circadian rhythms. Recent lines of evidence show that some homeobox genes even control expression of enzymes catalyzing melatonin synthesis. We here review current knowledge of homeobox genes in the rodent pineal gland and suggest a model for dual functions of homeobox gene-encoded transcription factors in developmental and circadian mature neuroendocrine function.

KW - circadian rhythm

KW - development

KW - homeobox gene

KW - melatonin

KW - pineal gland

U2 - 10.1111/jpi.12950

DO - 10.1111/jpi.12950

M3 - Review

C2 - 38558122

AN - SCOPUS:85189293303

VL - 76

JO - Journal of Pineal Research (Print)

JF - Journal of Pineal Research (Print)

SN - 0742-3098

IS - 3

M1 - e12950

ER -

ID: 388545421